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- W4384283534 endingPage "29" @default.
- W4384283534 startingPage "14" @default.
- W4384283534 abstract "Toxicology is an essential part of any drug development plan. Circumnavigating the risk of failure because of a toxicity issue can be a challenge, and failure in late development is extremely costly. To identify potential risks, it requires more than just understanding the biological target. The toxicologist needs to consider a compound's structure, it's physicochemical properties (including the impact of the overall formulation), as well as the biological target (e.g., receptor interactions). Understanding the impact of the physicochemical properties can be used to predict potential toxicities in advance by incorporating key endpoints in early screening strategies and/or used to compare toxicity profiles across lead candidates. This review discussed the risks of off-target and/or non-specific toxicities that may be associated with the physicochemical properties of compounds, especially those carrying dominant positive or negative charges, including amphiphilic small molecules, peptides, oligonucleotides and lipids/liposomes/lipid nanoparticles. The latter of which are being seen more and more in drug development, including the recent Covid pandemic, where mRNA and lipid nanoparticle technology is playing more of a role in vaccine development. The translation between non-clinical and clinical data is also considered, questioning how a physicochemical driven toxicity may be more universal across species, which means that such toxicity may be reassuringly translatable between species and as such, this information may also be considered as a support to the 3 R's, particularly in the early screening stages of a drug development plan." @default.
- W4384283534 created "2023-07-15" @default.
- W4384283534 creator A5055312945 @default.
- W4384283534 creator A5058244797 @default.
- W4384283534 date "2023-08-01" @default.
- W4384283534 modified "2023-09-25" @default.
- W4384283534 title "Off target toxicities and links with physicochemical properties of medicinal products, including antibiotics, oligonucleotides, lipid nanoparticles (with cationic and/or anionic charges). Data review suggests an emerging pattern" @default.
- W4384283534 cites W1240040893 @default.
- W4384283534 cites W1552409234 @default.
- W4384283534 cites W1699287294 @default.
- W4384283534 cites W1700995458 @default.
- W4384283534 cites W1884511587 @default.
- W4384283534 cites W1963696571 @default.
- W4384283534 cites W1968037013 @default.
- W4384283534 cites W1968238897 @default.
- W4384283534 cites W1974526584 @default.
- W4384283534 cites W1976301815 @default.
- W4384283534 cites W1980344266 @default.
- W4384283534 cites W1985069389 @default.
- W4384283534 cites W1987259801 @default.
- W4384283534 cites W1988602517 @default.
- W4384283534 cites W1994398448 @default.
- W4384283534 cites W1995933111 @default.
- W4384283534 cites W1997878371 @default.
- W4384283534 cites W1997998339 @default.
- W4384283534 cites W1998851722 @default.
- W4384283534 cites W1999313169 @default.
- W4384283534 cites W2004148398 @default.
- W4384283534 cites W2005044790 @default.
- W4384283534 cites W2005411014 @default.
- W4384283534 cites W2006945161 @default.
- W4384283534 cites W2007096781 @default.
- W4384283534 cites W2014086318 @default.
- W4384283534 cites W2018363833 @default.
- W4384283534 cites W2018453465 @default.
- W4384283534 cites W2020755269 @default.
- W4384283534 cites W2021591903 @default.
- W4384283534 cites W2029263042 @default.
- W4384283534 cites W2029772834 @default.
- W4384283534 cites W2030120319 @default.
- W4384283534 cites W2037492976 @default.
- W4384283534 cites W2037695327 @default.
- W4384283534 cites W2038477071 @default.
- W4384283534 cites W2038566882 @default.
- W4384283534 cites W2042721486 @default.
- W4384283534 cites W2044618657 @default.
- W4384283534 cites W2045029341 @default.
- W4384283534 cites W2045050168 @default.
- W4384283534 cites W2045110119 @default.
- W4384283534 cites W2045847395 @default.
- W4384283534 cites W2047036303 @default.
- W4384283534 cites W2050546805 @default.
- W4384283534 cites W2054889018 @default.
- W4384283534 cites W2056412962 @default.
- W4384283534 cites W2056811697 @default.
- W4384283534 cites W2057353956 @default.
- W4384283534 cites W2058165751 @default.
- W4384283534 cites W2059588956 @default.
- W4384283534 cites W2066964307 @default.
- W4384283534 cites W2069261831 @default.
- W4384283534 cites W2069757130 @default.
- W4384283534 cites W2070692558 @default.
- W4384283534 cites W2072583414 @default.
- W4384283534 cites W2073696812 @default.
- W4384283534 cites W2074213538 @default.
- W4384283534 cites W2075020461 @default.
- W4384283534 cites W2077732560 @default.
- W4384283534 cites W2086856055 @default.
- W4384283534 cites W2088707712 @default.
- W4384283534 cites W2089377837 @default.
- W4384283534 cites W2090137426 @default.
- W4384283534 cites W2092474773 @default.
- W4384283534 cites W2093039447 @default.
- W4384283534 cites W2096733541 @default.
- W4384283534 cites W2100902668 @default.
- W4384283534 cites W2106555579 @default.
- W4384283534 cites W2110605441 @default.
- W4384283534 cites W2111892802 @default.
- W4384283534 cites W2114051020 @default.
- W4384283534 cites W2114775015 @default.
- W4384283534 cites W2118601234 @default.
- W4384283534 cites W2121716650 @default.
- W4384283534 cites W2122941511 @default.
- W4384283534 cites W2123034315 @default.
- W4384283534 cites W2123366113 @default.
- W4384283534 cites W2125460615 @default.
- W4384283534 cites W2127747052 @default.
- W4384283534 cites W2129260942 @default.
- W4384283534 cites W2132963724 @default.
- W4384283534 cites W2142563310 @default.
- W4384283534 cites W2147417135 @default.
- W4384283534 cites W2152172471 @default.
- W4384283534 cites W2154236524 @default.
- W4384283534 cites W2155491988 @default.
- W4384283534 cites W2156160866 @default.
- W4384283534 cites W2158482458 @default.
- W4384283534 cites W2159869759 @default.
- W4384283534 cites W2169309865 @default.