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- W4384283631 abstract "Background Low level laser acupuncture (LLLA) biostimulation could contribute to improving the core symptoms and communication abilities of children manifesting autism spectrum disorder (ASD). Photobiomodulation might influence the level of brain derived neurotrophic factor (BDNF) and miR-320 expression. The aim was to investigate the influence of LLLA biostimulation on the severity, language abilities, BDNF levels, and miR-320 in a sample of ASD children. Methods The participants with ASD (N=30) were randomly divided equally into groups: Group I, received LLLA therapy twice a week for 12 sessions, and Group II, did not receive it. Assessments of the severity, their language abilities, BDNF level by ELISA, and miR-320 expression by (qRT-PCR) were performed before and after the intervention. A comparison between ASD cases (N=30) before starting the therapy and neurotypical children (N=15) regarding miR-320 expression was performed. Results Following the intervention, the severity of ASD was reduced, and language performance was elevated in both groups. The improvement in Group I was higher compared to Group II (p=0.002;0.03). The plasma BDNF level was reduced only in Group I (P<0.001). The expression level of miR-320 in Group I did not show a change (P=0.641). A significant difference in miR-320 expression between ASD children and the neurotypical group (P=0.000) was observed. Conclusion This study introduces LLLA therapy as a safe and promising therapeutic procedure for improving the core manifestations and communication abilities and for modulating BDNF levels in children with ASD. The reduced expression of miR-320 showed a good diagnostic value in ASD children." @default.
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- W4384283631 date "2023-10-01" @default.
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- W4384283631 title "Efficacy of Laser Acupuncture for Children With Autism Spectrum Disorder: Clinical, Molecular, and Biochemical Study" @default.
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- W4384283631 doi "https://doi.org/10.1016/j.pediatrneurol.2023.07.009" @default.
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