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• W4384283641 endingPage "105054" @default.
• W4384283641 startingPage "105054" @default.
• W4384283641 abstract "Neurodegenerative diseases are often characterized by the co-deposition of different amyloidogenic proteins, normally defining distinct proteinopathies.An example is represented by prion diseases, where the classical deposition of the aberrant conformational isoform of the prion protein (PrPSc) can be associated with tau insoluble species, which are usually involved in another class of diseases called tauopathies. How this copresence of amyloidogenic proteins can influence the progression of prion diseases is still a matter of debate.Recently, the cellular form of the prion protein, PrPC, has been investigated as a possible receptor of amyloidogenic proteins, since its binding activity with Aβ, tau and α-synuclein has been reported and it has been linked to several neurotoxic behaviours exerted by these proteins.We have previously shown that the treatment of chronically prion-infected cells with tau K18 fibrils reduced PrPSc levels. In this work, we further explored this mechanism by using another tau construct that includes the sequence that forms the core of Alzheimer’s disease tau filaments in vivo, to obtain a distinct fibril type. Despite a difference of six amino acids, these two constructs form fibrils characterized by distinct biochemical and biological features. However, their effects on PrPSc reduction were comparable and probably based on the binding to PrPC at the plasma membrane, inhibiting the pathological conversion event.Our results suggest PrPC as receptor for different types of tau fibrils and point out a role of tau amyloid fibrils in preventing the pathological PrPC to PrPSc conformational change." @default.
• W4384283641 created "2023-07-15" @default.
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• W4384283641 date "2023-08-01" @default.
• W4384283641 modified "2023-10-14" @default.
• W4384283641 title "Different tau fibril types reduce prion level in chronically and de novo infected cells" @default.
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• W4384283641 doi "https://doi.org/10.1016/j.jbc.2023.105054" @default.
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