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- W4384283669 abstract "Colorectal cancer is one of the most frequent malignancies worldwide. An uncontrolled growth of the body’s cells can lead to cancer. Cancer of the large intestine (colon) is one of the main causes of death due to cancer. The present study was designed to find the potential phytocompounds from Indian medicinal plants against Colorectal cancer (CRC) using in silico studies. The 3D structure of the target protein was retrieved from the PDB database. The 3D structure of phytocompounds was obtained using IMPPAT, PubChem and Dr. Duke’s database. The Lipinski rule of five for all the phytocompounds was tested using SwissADME. The docking studies were performed using PyRx, and the results were analyzed using Discovery Studio 2021. From the results, the phytocompounds Pamoic acid, Fernenol, and Diosgenin showed very good binding affinity like -9.7, -9.4, and -9.1 Kcal/mol, respectively. Toxicity studies were done for the best-interacted phytocompounds, and the results showed that the compounds had very less toxicity. The present study concludes that Pamoic acid from Catharanthus roseus, Fernenol from Artemisia vulgaris, and Diosgenin from Solanum nigrum has the potential ability to act as a drug for treating colorectal cancer (CRC)." @default.
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- W4384283669 date "2023-06-30" @default.
- W4384283669 modified "2023-09-25" @default.
- W4384283669 title "Finding Focal Adhesion Kinase Inhibitors from Indian Medicinal Plants for Colorectal Cancer- An In-silico Approach" @default.
- W4384283669 doi "https://doi.org/10.31254/jahm.2023.9205" @default.
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