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- W4384284671 abstract "N-N axially chiral biaryls represent a rarely explored class of atropisomeric compounds. We hereby report rhodium-catalyzed enantioselective [4 + 2] oxidative annulation of internal alkynes with benzamides bearing two classes of N-N directing groups. The coupling occurs under mild conditions via NH and CH annulation through the dynamic kinetic transformation of the directing group and is highly enantioselective with good functional tolerance. Computational studies of a coupling system at the DFT level has been conducted, and the alkyne insertion was identified as the enantio-determining as well as the turnover-limiting step." @default.
- W4384284671 created "2023-07-15" @default.
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- W4384284671 date "2023-01-01" @default.
- W4384284671 modified "2023-10-14" @default.
- W4384284671 title "Rhodium-catalyzed annulative approach to N–N axially chiral biaryls <i>via</i> C–H activation and dynamic kinetic transformation" @default.
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- W4384284671 doi "https://doi.org/10.1039/d3sc02800c" @default.
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