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- W4384296039 endingPage "115137" @default.
- W4384296039 startingPage "115137" @default.
- W4384296039 abstract "Depression is a multifactorial syndrome with a variety of underlying pathological mechanisms. While ketamine, an N-methyl-D-aspartate receptor (NMDAR) antagonist, exhibits a rapid antidepressant action in the central never system (CNS), the potential addiction and psychotomimetic adverse effects of ketamine limit its chronic use in clinical practice. Therefore, it is necessary to discover an additional agent that shows a synergistic antidepressant activity with ketamine to sustain its therapeutic action so as to reduce its use frequency in depression treatment. The present study indicated that Dajianzhong decoction (DJZT), an empirical herbal formula used for the clinical treatment of several inflammation-related intestinal disorders, sustains behavioral and synaptic action of ketamine in depressive mouse models. Additionally, ketamine was also demonstrated to exert a synergistic action with DJZT to alleviate the chronic unpredictable mild stress (CUMS)-induced abnormalities in gut barrier proteins and colonic histology, and subsequently to normalize the diversity and composition of gut microbiota. Furthermore, DJZT was shown to possess an anti-inflammatory activity to prevent activation of NF-κB from releasing proinflammatory cytokines, specifically through inhibiting Th17 cells/IL-17A pathway. Our results uncovered the mechanism of action of DJZT in conjunction with ketamine in depression treatment by which these agents target different pathological factors across biological systems and exert a synergistic activity through a bidirectional communication in the gut-brain axis, and also provided new insights into the systematic treatment of depression." @default.
- W4384296039 created "2023-07-15" @default.
- W4384296039 creator A5002421240 @default.
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- W4384296039 creator A5054210666 @default.
- W4384296039 creator A5074736274 @default.
- W4384296039 creator A5084838960 @default.
- W4384296039 date "2023-09-01" @default.
- W4384296039 modified "2023-10-06" @default.
- W4384296039 title "The synergistic mechanism of action of Dajianzhong decoction in conjunction with ketamine in the treatment of depression" @default.
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