Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384296487> ?p ?o ?g. }
- W4384296487 abstract "Abstract Although compositional variation in the gut microbiome during human development has been extensively investigated, strain-resolved dynamic changes remain to be fully uncovered. In the current study, shotgun metagenomic sequencing data of 12,415 fecal microbiomes from healthy individuals are employed for strain-level tracking of gut microbiota members to elucidate its evolving biodiversity across the human life span. This detailed longitudinal meta-analysis reveals host sex-related persistence of strains belonging to common, maternally-inherited species, such as Bifidobacterium bifidum and Bifidobacterium longum subsp. longum . Comparative genome analyses, coupled with experiments including intimate interaction between microbes and human intestinal cells, show that specific bacterial glycosyl hydrolases related to host-glycan metabolism may contribute to more efficient colonization in females compared to males. These findings point to an intriguing ancient sex-specific host-microbe coevolution driving the selective persistence in women of key microbial taxa that may be vertically passed on to the next generation." @default.
- W4384296487 created "2023-07-15" @default.
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- W4384296487 date "2023-07-14" @default.
- W4384296487 modified "2023-09-26" @default.
- W4384296487 title "Genetic strategies for sex-biased persistence of gut microbes across human life" @default.
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