FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384297172> ?p ?o ?g. }

• W4384297172 endingPage "130427" @default.
• W4384297172 startingPage "130427" @default.
• W4384297172 abstract "Transport functions of albumin are of clinical and pharmacological interest and are determined by albumin's properties like posttranslational modifications or bound ligands. Both are affected in pathological conditions and in therapeutic grade albumin solutions. The term effective albumin concentration was introduced as a measure of functionally intact albumin. Our aim was to evaluate the impact of ligands and modifications with different approaches as a measure of effective albumin. We used a spin labelled fatty acid and dansylsarcosine to characterize binding properties of albumin i) prepared from plasma of patients and healthy control donors, ii) measured directly out of plasma, iii) research grade albumin, iv) in vitro modified albumin, and v) therapeutic infusion solutions before and after removal of stabilizers. Bilirubin is the main determinant for binding function in patients' albumin. In in vitro prepared albumin bound fatty acids correlated with impaired binding. Human nonmercaptalbumin1, not human nonmercaptalbumin2, showed reduced binding properties. Binding and transport function of therapeutic albumin was severely impaired and restored by filtration. Glycation of research grade albumin had no effect on the binding of dansylsarcosine and only a minor effect on fatty acid binding. Our results suggest that effective albumin -in terms of binding properties- is primarily determined by bound ligands and only to a minor extent by posttranslational modifications. Characterizing albumin directly from plasma better reflects the physiological situation whereas in the case of therapeutic grade albumin stabilizers should be removed to make its binding properties accessible." @default.
• W4384297172 created "2023-07-15" @default.
• W4384297172 creator A5012979722 @default.
• W4384297172 creator A5024654230 @default.
• W4384297172 creator A5024886793 @default.
• W4384297172 creator A5026730867 @default.
• W4384297172 creator A5031485095 @default.
• W4384297172 creator A5052789086 @default.
• W4384297172 creator A5058760209 @default.
• W4384297172 creator A5084011321 @default.
• W4384297172 date "2023-09-01" @default.
• W4384297172 modified "2023-10-15" @default.
• W4384297172 title "Determination of binding characteristics as a measure for effective albumin using different methods" @default.
• W4384297172 cites W1489376146 @default.
• W4384297172 cites W1514417416 @default.
• W4384297172 cites W1515971740 @default.
• W4384297172 cites W1638063349 @default.
• W4384297172 cites W1899279709 @default.
• W4384297172 cites W1901598726 @default.
• W4384297172 cites W1966971846 @default.
• W4384297172 cites W1972418851 @default.
• W4384297172 cites W1977892627 @default.
• W4384297172 cites W1991423922 @default.
• W4384297172 cites W1992391397 @default.
• W4384297172 cites W1997295916 @default.
• W4384297172 cites W1998643708 @default.
• W4384297172 cites W2005337709 @default.
• W4384297172 cites W2007442469 @default.
• W4384297172 cites W2031985670 @default.
• W4384297172 cites W2032818619 @default.
• W4384297172 cites W2039705432 @default.
• W4384297172 cites W2043447398 @default.
• W4384297172 cites W2045589905 @default.
• W4384297172 cites W2055066199 @default.
• W4384297172 cites W2062502161 @default.
• W4384297172 cites W2071668239 @default.
• W4384297172 cites W2083811535 @default.
• W4384297172 cites W2084017971 @default.
• W4384297172 cites W2087770938 @default.
• W4384297172 cites W2090427843 @default.
• W4384297172 cites W2108876242 @default.
• W4384297172 cites W2127400446 @default.
• W4384297172 cites W2153556181 @default.
• W4384297172 cites W2154481915 @default.
• W4384297172 cites W2157020830 @default.
• W4384297172 cites W2157438880 @default.
• W4384297172 cites W2162916870 @default.
• W4384297172 cites W2164354906 @default.
• W4384297172 cites W2168090948 @default.
• W4384297172 cites W2172024510 @default.
• W4384297172 cites W2276498329 @default.
• W4384297172 cites W2776408858 @default.
• W4384297172 cites W2784925939 @default.
• W4384297172 cites W2785543274 @default.
• W4384297172 cites W2806141881 @default.
• W4384297172 cites W2904128737 @default.
• W4384297172 cites W3134430263 @default.
• W4384297172 cites W3173075894 @default.
• W4384297172 cites W4206611416 @default.
• W4384297172 doi "https://doi.org/10.1016/j.bbagen.2023.130427" @default.
• W4384297172 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37454915" @default.
• W4384297172 hasPublicationYear "2023" @default.
• W4384297172 type Work @default.
• W4384297172 citedByCount "1" @default.
• W4384297172 countsByYear W43842971722023 @default.
• W4384297172 crossrefType "journal-article" @default.
• W4384297172 hasAuthorship W4384297172A5012979722 @default.
• W4384297172 hasAuthorship W4384297172A5024654230 @default.
• W4384297172 hasAuthorship W4384297172A5024886793 @default.
• W4384297172 hasAuthorship W4384297172A5026730867 @default.
• W4384297172 hasAuthorship W4384297172A5031485095 @default.
• W4384297172 hasAuthorship W4384297172A5052789086 @default.
• W4384297172 hasAuthorship W4384297172A5058760209 @default.
• W4384297172 hasAuthorship W4384297172A5084011321 @default.
• W4384297172 hasConcept C107824862 @default.
• W4384297172 hasConcept C147990577 @default.
• W4384297172 hasConcept C165616093 @default.
• W4384297172 hasConcept C170493617 @default.
• W4384297172 hasConcept C185592680 @default.
• W4384297172 hasConcept C202751555 @default.
• W4384297172 hasConcept C2776125364 @default.
• W4384297172 hasConcept C43617362 @default.
• W4384297172 hasConcept C51639874 @default.
• W4384297172 hasConcept C55493867 @default.
• W4384297172 hasConceptScore W4384297172C107824862 @default.
• W4384297172 hasConceptScore W4384297172C147990577 @default.
• W4384297172 hasConceptScore W4384297172C165616093 @default.
• W4384297172 hasConceptScore W4384297172C170493617 @default.
• W4384297172 hasConceptScore W4384297172C185592680 @default.
• W4384297172 hasConceptScore W4384297172C202751555 @default.
• W4384297172 hasConceptScore W4384297172C2776125364 @default.
• W4384297172 hasConceptScore W4384297172C43617362 @default.
• W4384297172 hasConceptScore W4384297172C51639874 @default.
• W4384297172 hasConceptScore W4384297172C55493867 @default.
• W4384297172 hasIssue "9" @default.
• W4384297172 hasLocation W43842971721 @default.
• W4384297172 hasLocation W43842971722 @default.
• W4384297172 hasOpenAccess W4384297172 @default.

• next