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- W4384297386 abstract "The main challenge of cancer chemotherapy is the resistance of tumor cells to oxidative damage. Herein, we proposed a novel antitumor strategy: cyclic metal‑ruthenium (Ru) complexes mediate reductive damage to kill tumor cells. We designed and synthesized Ru(II) complexes with β-carboline as ligands: [Ru (phen)2(NO2-Ph-βC)](PF6) (RuβC-7) and [Ru(phen)2(1-Ph-βC)](PF6) (RuβC-8). In vitro experimental results showed that RuβC-7 and RuβC-8 can inhibit cell proliferation, promote mitochondrial abnormalities, and induce DNA damage. Interestingly, RuβC-7 with SOD activity could reduce intracellular reactive oxygen species (ROS) levels, while RuβC-8 has the opposite effect. Accordingly, this study identified the reductive damage mechanism of tumor apoptosis, and may provide a new ideas for the design of novel metal complexes." @default.
- W4384297386 created "2023-07-15" @default.
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- W4384297386 date "2023-10-01" @default.
- W4384297386 modified "2023-10-17" @default.
- W4384297386 title "Cyclometalated ruthenium (II) complexes induced HeLa cell apoptosis through intracellular reductive injury" @default.
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- W4384297386 doi "https://doi.org/10.1016/j.jinorgbio.2023.112333" @default.
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