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• W4384298001 abstract "Abstract Protein misfolding and aggregation play a role in amyloidogenic diseases through the self-assembly of intrinsically disordered proteins (IDPs) in type II diabetes (T2D), Alzheimer's (AD) and Parkinson's (PD) diseases. PD is the most common neurodegenerative disorder after AD, known for the loss of dopaminergic signaling, which causes motor and non-motor signs and symptoms. Lewy bodies and Lewy neurites are common pathological hallmarks of PD that are mainly composed of an aggregate of the disordered protein, α-synuclein (α-Syn). There have been many efforts to develop chemical-based compounds to prevent aggregation or facilitate disruption of the fibrils. These have been tested in wet labs, but most fail to generate a robust impact. Further, the atomistic roles and interactions of such compounds have yet to be revealed. The conformational diversity and detailed interactions among homo-oligomer chains of α-Syn are also unknown; identifying these might help uncover a practical approach to developing a potent therapy. In this study, we use an in-silico investigation to address the conformational diversity of α-Syn oligomers. The roles of several point mutations in protein aggregation in PD are known; we take this further by evaluating the interactional energies and contributions of all residues in stability and chain–chain interactions. We dock three chemical derivatives of known compounds with high-score drug-likeness to evaluate the roles of our ligands in the conformational dynamicity of the oligomers, with emphasis on intramolecular forces. Preventing fibril formations is a heated topic in this area. Free energy evaluation of the modeled inter- and intramolecular interactions through MD simulation shows strong binding between α-Syn compounds. However, we find that they do not disrupt or even weaken the interactions, and in some cases, they contributed to boosting interactions between oligomer chains." @default.
• W4384298001 created "2023-07-15" @default.
• W4384298001 creator A5002970194 @default.
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• W4384298001 date "2023-07-14" @default.
• W4384298001 modified "2023-10-16" @default.
• W4384298001 title "Conformational Dynamics of α-Synuclein: A Study of its Intramolecular Forces in the Presence of Selected Compounds" @default.
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• W4384298001 doi "https://doi.org/10.21203/rs.3.rs-3137135/v1" @default.
• W4384298001 hasPublicationYear "2023" @default.
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