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- W4384298046 abstract "Preterm birth (PTB), defined as the birth of a child before 37 completed weeks gestation, affects approximately 11% of live births and is the leading cause of death in children under 5 years. PTB is a complex disease with multiple risk factors including genetic variation. Much research has aimed to establish the biological mechanisms underlying PTB often through identification of genetic markers for PTB risk. The objective of this review is to present a comprehensive and updated summary of the published data relating to the field of PTB genetics. A literature search in PubMed was conducted and English studies related to PTB genetics were included. Genetic studies have identified genes within inflammatory, immunological, tissue remodeling, endocrine, metabolic, and vascular pathways that may be involved in PTB. However, a substantial proportion of published data have been largely inconclusive and multiple studies had limited power to detect associations. On the contrary, a few large hypothesis-free approaches have identified and replicated multiple novel variants associated with PTB in different cohorts. Overall, attempts to predict PTB using single -omics datasets including genomic, transcriptomic, and epigenomic biomarkers have been mostly unsuccessful and have failed to translate to the clinical setting. Integration of data from multiple -omics datasets has yielded the most promising results." @default.
- W4384298046 created "2023-07-15" @default.
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- W4384298046 date "2023-07-14" @default.
- W4384298046 modified "2023-09-30" @default.
- W4384298046 title "The Role of Genetics in Preterm Birth" @default.
- W4384298046 cites W1500243510 @default.
- W4384298046 cites W1530373619 @default.
- W4384298046 cites W1550818700 @default.
- W4384298046 cites W1602964370 @default.
- W4384298046 cites W1951481734 @default.
- W4384298046 cites W1965288319 @default.
- W4384298046 cites W1965954202 @default.
- W4384298046 cites W1967492171 @default.
- W4384298046 cites W1968631492 @default.
- W4384298046 cites W1969271586 @default.
- W4384298046 cites W1969389204 @default.
- W4384298046 cites W1969673534 @default.
- W4384298046 cites W1971321176 @default.
- W4384298046 cites W1975755498 @default.
- W4384298046 cites W1976798076 @default.
- W4384298046 cites W1979911598 @default.
- W4384298046 cites W1980036246 @default.
- W4384298046 cites W1981050315 @default.
- W4384298046 cites W1985419446 @default.
- W4384298046 cites W1991047945 @default.
- W4384298046 cites W1993488561 @default.
- W4384298046 cites W1993795964 @default.
- W4384298046 cites W1999177171 @default.
- W4384298046 cites W1999307705 @default.
- W4384298046 cites W2000677336 @default.
- W4384298046 cites W2004134089 @default.
- W4384298046 cites W2006963237 @default.
- W4384298046 cites W2009333016 @default.
- W4384298046 cites W2010101647 @default.
- W4384298046 cites W2013995717 @default.
- W4384298046 cites W2014837477 @default.
- W4384298046 cites W2026885603 @default.
- W4384298046 cites W2033465810 @default.
- W4384298046 cites W2040196463 @default.
- W4384298046 cites W2041490610 @default.
- W4384298046 cites W2041756668 @default.
- W4384298046 cites W2042889949 @default.
- W4384298046 cites W2044037361 @default.
- W4384298046 cites W2046384469 @default.
- W4384298046 cites W2047886780 @default.
- W4384298046 cites W2047915096 @default.
- W4384298046 cites W2051566370 @default.
- W4384298046 cites W2051868855 @default.
- W4384298046 cites W2052494979 @default.
- W4384298046 cites W2053814054 @default.
- W4384298046 cites W2054681151 @default.
- W4384298046 cites W2056228221 @default.
- W4384298046 cites W2060835562 @default.
- W4384298046 cites W2062848322 @default.
- W4384298046 cites W2063627864 @default.
- W4384298046 cites W2064686707 @default.
- W4384298046 cites W2067591042 @default.
- W4384298046 cites W2074579392 @default.
- W4384298046 cites W2076893595 @default.
- W4384298046 cites W2078237085 @default.
- W4384298046 cites W2081413171 @default.
- W4384298046 cites W2085755265 @default.
- W4384298046 cites W2091890376 @default.
- W4384298046 cites W2098482997 @default.
- W4384298046 cites W2098809414 @default.
- W4384298046 cites W2101507977 @default.
- W4384298046 cites W2104250249 @default.
- W4384298046 cites W2106668097 @default.
- W4384298046 cites W2111889965 @default.
- W4384298046 cites W2112927272 @default.
- W4384298046 cites W2113795839 @default.
- W4384298046 cites W2118242451 @default.
- W4384298046 cites W2120467276 @default.
- W4384298046 cites W2122732537 @default.
- W4384298046 cites W2127510146 @default.
- W4384298046 cites W2129714747 @default.
- W4384298046 cites W2132259499 @default.
- W4384298046 cites W2133917421 @default.
- W4384298046 cites W2137514719 @default.
- W4384298046 cites W2138020005 @default.
- W4384298046 cites W2139400710 @default.
- W4384298046 cites W2139808030 @default.
- W4384298046 cites W2140352353 @default.
- W4384298046 cites W2141749392 @default.
- W4384298046 cites W2142170372 @default.
- W4384298046 cites W2144644150 @default.
- W4384298046 cites W2145677401 @default.
- W4384298046 cites W2146128933 @default.
- W4384298046 cites W2148615135 @default.
- W4384298046 cites W2151706672 @default.