FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384300596> ?p ?o ?g. }

• W4384300596 endingPage "182" @default.
• W4384300596 startingPage "177" @default.
• W4384300596 abstract "Aim. To evaluate the effectiveness of the intrauterine levonorgestrel-releasing device (LNG-IUD) in the treatment of atypical hyperplasia and the use of LNG-IUD in combination with a gonadotropin-releasing hormone analog (3.6 mg goserelin depot) in the treatment of stage Ia highly differentiated endometrial adenocarcinoma in women wishing to preserve childbearing function, and to assess reproductive outcomes after treatment in these women.&#x0D; Materials and methods. A prospective and retrospective series of cases included all patients treated with LNG-IUD or LNG-IUD combined with goserelin 3.2 for atypical hyperplasia or early endometrial cancer (EC) treated in the Department of Innovative Oncology and Gynecology of the Institute of Oncogynecology and Mammology of the Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology from January 2018 to March 2022. Response rates and the relationship of the response with clinical and pathological factors were calculated.&#x0D; Results. Fifty-six patients diagnosed with atypical hyperplasia or stage Ia highly differentiated endometrial adenocarcinoma were treated with LNG-IUD and LNG-IUD combined with 3.2 mg of goserelin. Of the 56 patients who completed a 6-month course of hormonal treatment, 42 (82%) showed a complete response: 22 (91.7%) with atypical endometrial hyperplasia (AEH) and 20 (74.1%) with EC. In 4 (7.8%) patients, a partial response was reported: 2 (8.3%) with AEH and 2 (7.4%) with EC. No response was noted in 5 (9.8%) patients in the EC group only. Childbirth was reported in 13 (23.2%) women: 8 (29.6%) with AEH and 5 (17.2%) with EC. Two (3.6%) women were in the second trimester of pregnancy, and 17 (30.4%) women had an early pregnancy loss; 7 (25.9%) of them had AEH, and 10 (34.5%) had EC. The positive response rate was 90.2% at 6 months: 24 (100%) patients with atypical hyperplasia and 22 (81.5%) with EC. Patients with EC in combination with polycystic ovary syndrome and obesity and patients with the non-obese EC phenotype had a lower therapy efficacy.&#x0D; Conclusion. LNG-IUD therapy for the conservative treatment of atypical hyperplasia and LNG-IUD therapy combined with goserelin 3.2 for early EC led to a morphological cure in most patients and can be considered for women planning pregnancy." @default.
• W4384300596 created "2023-07-15" @default.
• W4384300596 creator A5004045267 @default.
• W4384300596 creator A5028766555 @default.
• W4384300596 creator A5063119716 @default.
• W4384300596 creator A5069276613 @default.
• W4384300596 creator A5092469923 @default.
• W4384300596 date "2023-07-14" @default.
• W4384300596 modified "2023-09-25" @default.
• W4384300596 title "Outcomes of organ-preserving treatment of atypical hyperplasia and early stage endometrial cancer in reproductive age: A prospective and retrospective study" @default.
• W4384300596 cites W2010300549 @default.
• W4384300596 cites W2039043015 @default.
• W4384300596 cites W2097113048 @default.
• W4384300596 cites W2115448124 @default.
• W4384300596 cites W2163238865 @default.
• W4384300596 cites W3128646645 @default.
• W4384300596 cites W3162740612 @default.
• W4384300596 cites W4210989197 @default.
• W4384300596 cites W4211047904 @default.
• W4384300596 cites W4251110191 @default.
• W4384300596 doi "https://doi.org/10.26442/20795696.2023.2.202219" @default.
• W4384300596 hasPublicationYear "2023" @default.
• W4384300596 type Work @default.
• W4384300596 citedByCount "0" @default.
• W4384300596 crossrefType "journal-article" @default.
• W4384300596 hasAuthorship W4384300596A5004045267 @default.
• W4384300596 hasAuthorship W4384300596A5028766555 @default.
• W4384300596 hasAuthorship W4384300596A5063119716 @default.
• W4384300596 hasAuthorship W4384300596A5069276613 @default.
• W4384300596 hasAuthorship W4384300596A5092469923 @default.
• W4384300596 hasBestOaLocation W43843005961 @default.
• W4384300596 hasConcept C121608353 @default.
• W4384300596 hasConcept C126322002 @default.
• W4384300596 hasConcept C131872663 @default.
• W4384300596 hasConcept C167135981 @default.
• W4384300596 hasConcept C2776810592 @default.
• W4384300596 hasConcept C2777088508 @default.
• W4384300596 hasConcept C2777689261 @default.
• W4384300596 hasConcept C2778043895 @default.
• W4384300596 hasConcept C2779076696 @default.
• W4384300596 hasConcept C2779742232 @default.
• W4384300596 hasConcept C2780186607 @default.
• W4384300596 hasConcept C2908647359 @default.
• W4384300596 hasConcept C29456083 @default.
• W4384300596 hasConcept C2986817661 @default.
• W4384300596 hasConcept C530470458 @default.
• W4384300596 hasConcept C71924100 @default.
• W4384300596 hasConcept C99454951 @default.
• W4384300596 hasConceptScore W4384300596C121608353 @default.
• W4384300596 hasConceptScore W4384300596C126322002 @default.
• W4384300596 hasConceptScore W4384300596C131872663 @default.
• W4384300596 hasConceptScore W4384300596C167135981 @default.
• W4384300596 hasConceptScore W4384300596C2776810592 @default.
• W4384300596 hasConceptScore W4384300596C2777088508 @default.
• W4384300596 hasConceptScore W4384300596C2777689261 @default.
• W4384300596 hasConceptScore W4384300596C2778043895 @default.
• W4384300596 hasConceptScore W4384300596C2779076696 @default.
• W4384300596 hasConceptScore W4384300596C2779742232 @default.
• W4384300596 hasConceptScore W4384300596C2780186607 @default.
• W4384300596 hasConceptScore W4384300596C2908647359 @default.
• W4384300596 hasConceptScore W4384300596C29456083 @default.
• W4384300596 hasConceptScore W4384300596C2986817661 @default.
• W4384300596 hasConceptScore W4384300596C530470458 @default.
• W4384300596 hasConceptScore W4384300596C71924100 @default.
• W4384300596 hasConceptScore W4384300596C99454951 @default.
• W4384300596 hasIssue "2" @default.
• W4384300596 hasLocation W43843005961 @default.
• W4384300596 hasOpenAccess W4384300596 @default.
• W4384300596 hasPrimaryLocation W43843005961 @default.
• W4384300596 hasRelatedWork W2027516911 @default.
• W4384300596 hasRelatedWork W2142948690 @default.
• W4384300596 hasRelatedWork W2315190805 @default.
• W4384300596 hasRelatedWork W2499666044 @default.
• W4384300596 hasRelatedWork W2730226356 @default.
• W4384300596 hasRelatedWork W2771467906 @default.
• W4384300596 hasRelatedWork W3082043237 @default.
• W4384300596 hasRelatedWork W3150747552 @default.
• W4384300596 hasRelatedWork W4236579382 @default.
• W4384300596 hasRelatedWork W4361295204 @default.
• W4384300596 hasVolume "25" @default.
• W4384300596 isParatext "false" @default.
• W4384300596 isRetracted "false" @default.
• W4384300596 workType "article" @default.