FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384301014> ?p ?o ?g. }

• W4384301014 abstract "Abstract Background This study investigated a potential prognostic model based on telomere-related genes (TRGs) for the clinical prediction of oral squamous cell carcinoma (OSCC). Methods Gene expression data and associated clinical phenotypes were obtained from online databases. Differentially expressed (DE)-TRGs were identified between OSCC and normal samples, followed by protein-protein interaction and enrichment analyses. Subsequently, the prognostic genes explored based on the DE-TRGs and survival data were applied in the establishment of the current prognostic model, and an integrated analysis was performed between high- and low-risk groups using a prognostic model. The expression of certain prognostic genes identified in the present study was validated using qPCR analysis and/or western blot in OSCC cell lines and clinical samples. Results 169 DE-TRGs were identified between the OSCC samples and controls. DE-TRGs are mainly involved in functions such as hypoxia response and pathways such as the cell cycle. Eight TRGs (CCNB1, PDK4, PLOD2, RACGAP1, MET, PLK1, KPNA2, and CCNA2) associated with OSCC survival and prognosis were used to construct a prognostic model. qPCR analysis and western blot showed that most of the eight prognostic genes were consistent with the current bioinformatics results. Analysis of the high- and low-risk groups for OSCC determined by the prognostic model showed that the current prognostic model was reliable. Conclusions A novel prognostic model for OSCC was constructed by TRGs. PLOD2 and APLK1 may participate in the progression of OSCC via responses to hypoxia and cell cycle pathways, respectively. TRGs, including KPNA2 and CCNA2, may serve as novel prognostic biomarkers for OSCC." @default.
• W4384301014 created "2023-07-15" @default.
• W4384301014 creator A5041269918 @default.
• W4384301014 creator A5082360292 @default.
• W4384301014 date "2023-07-14" @default.
• W4384301014 modified "2023-09-22" @default.
• W4384301014 title "Prognostic model based on telomere-related genes predicts the risk of oral squamous cell carcinoma" @default.
• W4384301014 cites W1546952499 @default.
• W4384301014 cites W1987029023 @default.
• W4384301014 cites W2010457001 @default.
• W4384301014 cites W2015590366 @default.
• W4384301014 cites W2020541351 @default.
• W4384301014 cites W2032298886 @default.
• W4384301014 cites W2035895903 @default.
• W4384301014 cites W2047998870 @default.
• W4384301014 cites W2075294566 @default.
• W4384301014 cites W2084822939 @default.
• W4384301014 cites W2100838748 @default.
• W4384301014 cites W2103235020 @default.
• W4384301014 cites W2106391842 @default.
• W4384301014 cites W2107277218 @default.
• W4384301014 cites W2108355069 @default.
• W4384301014 cites W2149199519 @default.
• W4384301014 cites W2158217645 @default.
• W4384301014 cites W2159482845 @default.
• W4384301014 cites W2159675211 @default.
• W4384301014 cites W2159707944 @default.
• W4384301014 cites W2164156722 @default.
• W4384301014 cites W2192080449 @default.
• W4384301014 cites W2344528091 @default.
• W4384301014 cites W2473193283 @default.
• W4384301014 cites W2590697463 @default.
• W4384301014 cites W2789892633 @default.
• W4384301014 cites W2799951262 @default.
• W4384301014 cites W2803530368 @default.
• W4384301014 cites W2887134879 @default.
• W4384301014 cites W2911360266 @default.
• W4384301014 cites W2940765885 @default.
• W4384301014 cites W2949273159 @default.
• W4384301014 cites W2969718750 @default.
• W4384301014 cites W2980425804 @default.
• W4384301014 cites W2989722022 @default.
• W4384301014 cites W2994565852 @default.
• W4384301014 cites W2999041256 @default.
• W4384301014 cites W3011997653 @default.
• W4384301014 cites W3028304854 @default.
• W4384301014 cites W3121642246 @default.
• W4384301014 cites W3127921654 @default.
• W4384301014 cites W3174054965 @default.
• W4384301014 cites W3205330660 @default.
• W4384301014 cites W4200042076 @default.
• W4384301014 cites W4200311340 @default.
• W4384301014 cites W4200557988 @default.
• W4384301014 cites W4205097549 @default.
• W4384301014 cites W4223420473 @default.
• W4384301014 cites W4248422177 @default.
• W4384301014 cites W4283066967 @default.
• W4384301014 cites W4293574708 @default.
• W4384301014 cites W4294216483 @default.
• W4384301014 cites W4297905966 @default.
• W4384301014 cites W4307425304 @default.
• W4384301014 doi "https://doi.org/10.1186/s12903-023-03157-x" @default.
• W4384301014 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37452322" @default.
• W4384301014 hasPublicationYear "2023" @default.
• W4384301014 type Work @default.
• W4384301014 citedByCount "0" @default.
• W4384301014 crossrefType "journal-article" @default.
• W4384301014 hasAuthorship W4384301014A5041269918 @default.
• W4384301014 hasAuthorship W4384301014A5082360292 @default.
• W4384301014 hasBestOaLocation W43843010141 @default.
• W4384301014 hasConcept C104317684 @default.
• W4384301014 hasConcept C10515644 @default.
• W4384301014 hasConcept C121608353 @default.
• W4384301014 hasConcept C126322002 @default.
• W4384301014 hasConcept C143998085 @default.
• W4384301014 hasConcept C2776415932 @default.
• W4384301014 hasConcept C29537977 @default.
• W4384301014 hasConcept C502942594 @default.
• W4384301014 hasConcept C54355233 @default.
• W4384301014 hasConcept C71924100 @default.
• W4384301014 hasConcept C86803240 @default.
• W4384301014 hasConceptScore W4384301014C104317684 @default.
• W4384301014 hasConceptScore W4384301014C10515644 @default.
• W4384301014 hasConceptScore W4384301014C121608353 @default.
• W4384301014 hasConceptScore W4384301014C126322002 @default.
• W4384301014 hasConceptScore W4384301014C143998085 @default.
• W4384301014 hasConceptScore W4384301014C2776415932 @default.
• W4384301014 hasConceptScore W4384301014C29537977 @default.
• W4384301014 hasConceptScore W4384301014C502942594 @default.
• W4384301014 hasConceptScore W4384301014C54355233 @default.
• W4384301014 hasConceptScore W4384301014C71924100 @default.
• W4384301014 hasConceptScore W4384301014C86803240 @default.
• W4384301014 hasIssue "1" @default.
• W4384301014 hasLocation W43843010141 @default.
• W4384301014 hasLocation W43843010142 @default.
• W4384301014 hasLocation W43843010143 @default.
• W4384301014 hasOpenAccess W4384301014 @default.
• W4384301014 hasPrimaryLocation W43843010141 @default.
• W4384301014 hasRelatedWork W2009966535 @default.
• W4384301014 hasRelatedWork W2019988726 @default.

• next