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- W4384303313 abstract "Maynard Smith and others had shown that there was circumstantial evidence for antagonistic pleiotropy arising from the cost of reproduction. Brian Charlesworth had shown that such hypotheses could produce the evolution of aging, but these alternatives had not been directly tested in the genetic variation of an outbred population. It was thought that the mutation accumulation hypothesis implied that the additive genetic variance for age-specific survival or fecundity should increase massively with adult age. M.R. Rose and B. Charlesworth found no such effect; rather, genetic variances for age-specific fecundity were stable with adult age. On the other hand, antagonistic pleiotropy implies that there should be negative genetic correlations between early fecundity and longevity; such a negative genetic correlation was found. For the first time, evolutionary genetic speculations and mathematical models for aging received strong inference tests." @default.
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- W4384303313 date "2023-01-01" @default.
- W4384303313 modified "2023-10-18" @default.
- W4384303313 title "1980–81" @default.
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- W4384303313 doi "https://doi.org/10.1016/b978-0-12-821545-6.00012-1" @default.
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