FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384305930> ?p ?o ?g. }

• W4384305930 abstract "Celiac disease (CD) is an autoimmune disease in which intestinal inflammation is induced by dietary gluten. The means through which gluten-specific CD4 + T cell activation culminates in intraepithelial T cell (T-IEL)–mediated intestinal damage remain unclear. Here, we performed multiplexed single-cell analysis of intestinal and gluten-induced peripheral blood T cells from patients in different CD states and healthy controls. Untreated, active, and potential CD were associated with an enrichment of activated intestinal T cell populations, including CD4 + follicular T helper (T FH ) cells, regulatory T cells (T regs ), and natural CD8 + αβ and γδ T-IELs. Natural CD8 + αβ and γδ T-IELs expressing activating natural killer cell receptors (NKRs) exhibited a distinct TCR repertoire in CD and persisted in patients on a gluten-free diet without intestinal inflammation. Our data further show that NKR-expressing cytotoxic cells, which appear to mediate intestinal damage in CD, arise from a distinct NKR-expressing memory population of T-IELs. After gluten ingestion, both αβ and γδ T cell clones from this memory population of T-IELs circulated systemically along with gluten-specific CD4 + T cells and assumed a cytotoxic and activating NKR-expressing phenotype. Collectively, these findings suggest that cytotoxic T cells in CD are rapidly mobilized in parallel with gluten-specific CD4 + T cells after gluten ingestion." @default.
• W4384305930 created "2023-07-15" @default.
• W4384305930 creator A5002653621 @default.
• W4384305930 creator A5005379707 @default.
• W4384305930 creator A5005512235 @default.
• W4384305930 creator A5008294736 @default.
• W4384305930 creator A5013382491 @default.
• W4384305930 creator A5014232298 @default.
• W4384305930 creator A5014966517 @default.
• W4384305930 creator A5023739752 @default.
• W4384305930 creator A5029022253 @default.
• W4384305930 creator A5037192769 @default.
• W4384305930 creator A5042026897 @default.
• W4384305930 creator A5046972722 @default.
• W4384305930 creator A5051115910 @default.
• W4384305930 creator A5052909530 @default.
• W4384305930 creator A5055867587 @default.
• W4384305930 creator A5064089827 @default.
• W4384305930 creator A5068405730 @default.
• W4384305930 creator A5072983719 @default.
• W4384305930 creator A5074847949 @default.
• W4384305930 creator A5075747954 @default.
• W4384305930 creator A5092471195 @default.
• W4384305930 date "2023-07-21" @default.
• W4384305930 modified "2023-10-16" @default.
• W4384305930 title "Gluten induces rapid reprogramming of natural memory αβ and γδ intraepithelial T cells to induce cytotoxicity in celiac disease" @default.
• W4384305930 cites W1493822493 @default.
• W4384305930 cites W1777634864 @default.
• W4384305930 cites W1939904335 @default.
• W4384305930 cites W1964133627 @default.
• W4384305930 cites W1980021547 @default.
• W4384305930 cites W1980681594 @default.
• W4384305930 cites W1988159496 @default.
• W4384305930 cites W1990295999 @default.
• W4384305930 cites W1991473719 @default.
• W4384305930 cites W2000742295 @default.
• W4384305930 cites W2004663864 @default.
• W4384305930 cites W2008667095 @default.
• W4384305930 cites W2038976543 @default.
• W4384305930 cites W2069423665 @default.
• W4384305930 cites W2069642599 @default.
• W4384305930 cites W2076327296 @default.
• W4384305930 cites W2076534074 @default.
• W4384305930 cites W2079683856 @default.
• W4384305930 cites W2083392854 @default.
• W4384305930 cites W2095360455 @default.
• W4384305930 cites W2098035977 @default.
• W4384305930 cites W2100536595 @default.
• W4384305930 cites W2108557697 @default.
• W4384305930 cites W2116551829 @default.
• W4384305930 cites W2128452798 @default.
• W4384305930 cites W2133929474 @default.
• W4384305930 cites W2150743590 @default.
• W4384305930 cites W2164137002 @default.
• W4384305930 cites W2165547934 @default.
• W4384305930 cites W2202981992 @default.
• W4384305930 cites W2413587463 @default.
• W4384305930 cites W2413688885 @default.
• W4384305930 cites W2419191053 @default.
• W4384305930 cites W2585122285 @default.
• W4384305930 cites W2592869311 @default.
• W4384305930 cites W2610643013 @default.
• W4384305930 cites W2616922646 @default.
• W4384305930 cites W2774104433 @default.
• W4384305930 cites W2800036554 @default.
• W4384305930 cites W2907514116 @default.
• W4384305930 cites W2911922390 @default.
• W4384305930 cites W2912947431 @default.
• W4384305930 cites W2923342978 @default.
• W4384305930 cites W2939422961 @default.
• W4384305930 cites W2957317198 @default.
• W4384305930 cites W2966549733 @default.
• W4384305930 cites W2984587218 @default.
• W4384305930 cites W3005574648 @default.
• W4384305930 cites W3020331344 @default.
• W4384305930 cites W3047453719 @default.
• W4384305930 cites W3080380488 @default.
• W4384305930 cites W3126209299 @default.
• W4384305930 cites W3135043831 @default.
• W4384305930 cites W3137742875 @default.
• W4384305930 cites W3197553502 @default.
• W4384305930 cites W4211144941 @default.
• W4384305930 doi "https://doi.org/10.1126/sciimmunol.adf4312" @default.
• W4384305930 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37450575" @default.
• W4384305930 hasPublicationYear "2023" @default.
• W4384305930 type Work @default.
• W4384305930 citedByCount "2" @default.
• W4384305930 countsByYear W43843059302023 @default.
• W4384305930 crossrefType "journal-article" @default.
• W4384305930 hasAuthorship W4384305930A5002653621 @default.
• W4384305930 hasAuthorship W4384305930A5005379707 @default.
• W4384305930 hasAuthorship W4384305930A5005512235 @default.
• W4384305930 hasAuthorship W4384305930A5008294736 @default.
• W4384305930 hasAuthorship W4384305930A5013382491 @default.
• W4384305930 hasAuthorship W4384305930A5014232298 @default.
• W4384305930 hasAuthorship W4384305930A5014966517 @default.
• W4384305930 hasAuthorship W4384305930A5023739752 @default.
• W4384305930 hasAuthorship W4384305930A5029022253 @default.
• W4384305930 hasAuthorship W4384305930A5037192769 @default.
• W4384305930 hasAuthorship W4384305930A5042026897 @default.

• next