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• W4384306063 abstract "Background : Acute kidney injury after pediatric cardiac surgery is a common complication with few established modifiable risk factors. We sought to characterize whether indexed oxygen delivery during cardiopulmonary bypass was associated with postoperative acute kidney injury in a large pediatric cohort. Methods : This was a retrospective analysis of patients under 1 year old undergoing cardiac surgery with cardiopulmonary bypass between January 1, 2013, and January 1, 2020. Receiver operating characteristic curves across values ranging from 260 to 400 mL/min/m 2 were used to identify the indexed oxygen delivery most significantly associated with acute kidney injury risk. Results : We included 980 patients with acute kidney injury occurring in 212 (21.2%). After adjusting for covariates associated with acute kidney injury, an indexed oxygen delivery threshold of 340 mL/min/m 2 predicted acute kidney injury in STAT 4 and 5 neonates (area under the curve = 0.66, 95% CI = 0.60 – 0.72, sensitivity = 56.1%, specificity = 69.4%). An indexed oxygen delivery threshold of 400 mL/min/m 2 predicted acute kidney injury in STAT 1-3 infants (area under the curve = 0.65, 95% CI = 0.58 – 0.72, sensitivity = 52.6%, specificity = 74.6%). Conclusion : Indexed oxygen delivery during cardiopulmonary bypass is a modifiable variable independently associated with postoperative acute kidney injury in specific pediatric populations. Strategies aimed at maintaining oxygen delivery greater than 340 mL/min/m 2 in complex neonates and greater than 400 mL/min/m 2 in infants may reduce the occurrence of postoperative acute kidney injury in the pediatric population." @default.
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• W4384306063 date "2023-09-01" @default.
• W4384306063 modified "2023-09-26" @default.
• W4384306063 title "Indexed oxygen delivery during pediatric cardiopulmonary bypass is a modifiable risk factor for postoperative acute kidney injury" @default.
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• W4384306063 doi "https://doi.org/10.1051/ject/2023029" @default.
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