FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384306191> ?p ?o ?g. }

• W4384306191 endingPage "110643" @default.
• W4384306191 startingPage "110643" @default.
• W4384306191 abstract "The mesenchymal Stem Cells (MSCs) is one of the leading contender in therapeutic management of cytokine storm implicated in the COVID-19 and other inflammatory conditions. This study was aimed to investigate the effect of Interferon gamma (IFN-γ) and Ascorbic Acid (AA) preconditioning on the secretome of the human Umbilical Cord Derived MSCs (UCMSCs) and their potential to ameliorate the lipopolysaccharide (LPS) induced cytokine storm in the human peripheral blood mononuclear cells (PBMCs). UCMSCs were preconditioned with IFN-γ, AA and secretome (UCMSCs-S, IFNγ-UCMSCs-S and AA-UCSMCs-S) was analysed for the levels of growth factors and cytokines by flow cytometry. The potential of secretome to ameliorate cytokine storm and augment angiogenesis was assessed in the LPS induced PBMCs and yolk sac membrane (YSM) assay respectively. The mRNA transcript and protein levels of IL-6, IL-1β and TNF-α was analysed by RT-PCR and flow cytometry respectively. IFNγ-UCMSCs-S and AA-UCSMCs-S ameliorated the LPS induced cytokine storm as revealed by the decreased mRNA and protein expression of IL-6, IL-1β and TNF-α as compared to the UCMSCs-S. IFNγ-UCMSCs-S and AA-UCSMCs-S augmented angiogenesis in YSM assay. Furthermore, IFNγ and AA preconditioning of UCMSCs exhibited distinct growth factors and cytokine profile in the secretome. Our results unequivocally show that IFNγ and AA preconditioning of MSCs could give better therapeutic outcomes in the cell mediated therapies for COVID-19 and other inflammatory conditions." @default.
• W4384306191 created "2023-07-15" @default.
• W4384306191 creator A5018932329 @default.
• W4384306191 creator A5021861952 @default.
• W4384306191 creator A5040634531 @default.
• W4384306191 creator A5074652511 @default.
• W4384306191 date "2023-09-01" @default.
• W4384306191 modified "2023-10-02" @default.
• W4384306191 title "Ascorbic acid and IFNγ preconditioning enhance the potency of human mesenchymal stem cells to ameliorate LPS induced cytokine storm" @default.
• W4384306191 cites W1968559439 @default.
• W4384306191 cites W1981575054 @default.
• W4384306191 cites W1995286643 @default.
• W4384306191 cites W2002325129 @default.
• W4384306191 cites W2090934209 @default.
• W4384306191 cites W2145731936 @default.
• W4384306191 cites W2735254221 @default.
• W4384306191 cites W2766820812 @default.
• W4384306191 cites W2792667030 @default.
• W4384306191 cites W2795574285 @default.
• W4384306191 cites W2797130837 @default.
• W4384306191 cites W2888181686 @default.
• W4384306191 cites W3016075808 @default.
• W4384306191 cites W3020423761 @default.
• W4384306191 cites W3021577619 @default.
• W4384306191 cites W3022878099 @default.
• W4384306191 cites W3037676127 @default.
• W4384306191 cites W3113110940 @default.
• W4384306191 cites W3134383271 @default.
• W4384306191 cites W3134674969 @default.
• W4384306191 cites W3154092881 @default.
• W4384306191 cites W3174811176 @default.
• W4384306191 cites W3177234616 @default.
• W4384306191 cites W3178876092 @default.
• W4384306191 cites W3184178543 @default.
• W4384306191 cites W3192551599 @default.
• W4384306191 cites W3204641882 @default.
• W4384306191 cites W4220697442 @default.
• W4384306191 cites W4220773864 @default.
• W4384306191 cites W4280568646 @default.
• W4384306191 doi "https://doi.org/10.1016/j.intimp.2023.110643" @default.
• W4384306191 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37453155" @default.
• W4384306191 hasPublicationYear "2023" @default.
• W4384306191 type Work @default.
• W4384306191 citedByCount "0" @default.
• W4384306191 crossrefType "journal-article" @default.
• W4384306191 hasAuthorship W4384306191A5018932329 @default.
• W4384306191 hasAuthorship W4384306191A5021861952 @default.
• W4384306191 hasAuthorship W4384306191A5040634531 @default.
• W4384306191 hasAuthorship W4384306191A5074652511 @default.
• W4384306191 hasConcept C126322002 @default.
• W4384306191 hasConcept C137061746 @default.
• W4384306191 hasConcept C17991360 @default.
• W4384306191 hasConcept C198826908 @default.
• W4384306191 hasConcept C202751555 @default.
• W4384306191 hasConcept C203014093 @default.
• W4384306191 hasConcept C2778690821 @default.
• W4384306191 hasConcept C2778754761 @default.
• W4384306191 hasConcept C2779134260 @default.
• W4384306191 hasConcept C2779559532 @default.
• W4384306191 hasConcept C2780841837 @default.
• W4384306191 hasConcept C28328180 @default.
• W4384306191 hasConcept C2986274086 @default.
• W4384306191 hasConcept C3008058167 @default.
• W4384306191 hasConcept C31903555 @default.
• W4384306191 hasConcept C524204448 @default.
• W4384306191 hasConcept C553184892 @default.
• W4384306191 hasConcept C55493867 @default.
• W4384306191 hasConcept C71924100 @default.
• W4384306191 hasConcept C86803240 @default.
• W4384306191 hasConcept C95444343 @default.
• W4384306191 hasConceptScore W4384306191C126322002 @default.
• W4384306191 hasConceptScore W4384306191C137061746 @default.
• W4384306191 hasConceptScore W4384306191C17991360 @default.
• W4384306191 hasConceptScore W4384306191C198826908 @default.
• W4384306191 hasConceptScore W4384306191C202751555 @default.
• W4384306191 hasConceptScore W4384306191C203014093 @default.
• W4384306191 hasConceptScore W4384306191C2778690821 @default.
• W4384306191 hasConceptScore W4384306191C2778754761 @default.
• W4384306191 hasConceptScore W4384306191C2779134260 @default.
• W4384306191 hasConceptScore W4384306191C2779559532 @default.
• W4384306191 hasConceptScore W4384306191C2780841837 @default.
• W4384306191 hasConceptScore W4384306191C28328180 @default.
• W4384306191 hasConceptScore W4384306191C2986274086 @default.
• W4384306191 hasConceptScore W4384306191C3008058167 @default.
• W4384306191 hasConceptScore W4384306191C31903555 @default.
• W4384306191 hasConceptScore W4384306191C524204448 @default.
• W4384306191 hasConceptScore W4384306191C553184892 @default.
• W4384306191 hasConceptScore W4384306191C55493867 @default.
• W4384306191 hasConceptScore W4384306191C71924100 @default.
• W4384306191 hasConceptScore W4384306191C86803240 @default.
• W4384306191 hasConceptScore W4384306191C95444343 @default.
• W4384306191 hasLocation W43843061911 @default.
• W4384306191 hasLocation W43843061912 @default.
• W4384306191 hasOpenAccess W4384306191 @default.
• W4384306191 hasPrimaryLocation W43843061911 @default.
• W4384306191 hasRelatedWork W1994050787 @default.
• W4384306191 hasRelatedWork W2001305916 @default.
• W4384306191 hasRelatedWork W2029372981 @default.

• next