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- W4384337975 abstract "Functional magnetic resonance imaging (fMRI) is an indirect measure of neural activity with the hemodynamic response function (HRF) coupling it with unmeasured neural activity. The HRF, modulated by several non-neural factors, is variable across brain regions, individuals and populations. Yet, a majority of human resting-state fMRI connectivity studies continue to assume a non-variable HRF. In this article, with supportive prior evidence, we argue that HRF variability cannot be ignored as it substantially confounds within-subject connectivity estimates and between-subjects connectivity group differences. We also discuss its clinical relevance with connectivity impairments confounded by HRF aberrations in several disorders. We present limited data on HRF differences between women and men, which resulted in a 15.4% median error in functional connectivity estimates in a group-level comparison. We also discuss the implications of HRF variability for fMRI studies in the spinal cord. There is a need for more dialogue within the community on the HRF confound, and we hope that our article is a catalyst in the process." @default.
- W4384337975 created "2023-07-15" @default.
- W4384337975 creator A5000419170 @default.
- W4384337975 creator A5088297619 @default.
- W4384337975 creator A5090174397 @default.
- W4384337975 date "2023-07-14" @default.
- W4384337975 modified "2023-09-25" @default.
- W4384337975 title "The confound of hemodynamic response function variability in human resting-state functional MRI studies" @default.
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