Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384337998> ?p ?o ?g. }
- W4384337998 abstract "Dendritic cells (DCs) are sentinel immune cells that form a critical bridge linking the innate and adaptive immune systems. Extensive research addressing the cellular origin and heterogeneity of the DC network has revealed the essential role played by the spatiotemporal activity of key transcription factors. In response to environmental signals DC mature but it is only following the sensing of environmental signals that DC can induce an antigen specific T cell response. Thus, whilst the coordinate action of transcription factors governs DC differentiation, sensing of environmental signals by DC is instrumental in shaping their functional properties. In this review, we provide an overview that focuses on recent advances in understanding the transcriptional networks that regulate the development of the reported DC subsets, shedding light on the function of different DC subsets. Specifically, we discuss the emerging knowledge on the heterogeneity of cDC2s, the ontogeny of pDCs, and the newly described DC subset, DC3. Additionally, we examine critical transcription factors such as IRF8, PU.1, and E2-2 and their regulatory mechanisms and downstream targets. We highlight the complex interplay between these transcription factors, which shape the DC transcriptome and influence their function in response to environmental stimuli. The information presented in this review provides essential insights into the regulation of DC development and function, which might have implications for developing novel therapeutic strategies for immune-related diseases." @default.
- W4384337998 created "2023-07-15" @default.
- W4384337998 creator A5003798176 @default.
- W4384337998 creator A5008189988 @default.
- W4384337998 creator A5035108862 @default.
- W4384337998 creator A5038108688 @default.
- W4384337998 date "2023-07-14" @default.
- W4384337998 modified "2023-09-25" @default.
- W4384337998 title "Transcriptional regulation of dendritic cell development and function" @default.
- W4384337998 cites W1053344571 @default.
- W4384337998 cites W1488772574 @default.
- W4384337998 cites W1517310071 @default.
- W4384337998 cites W1541999139 @default.
- W4384337998 cites W1661544713 @default.
- W4384337998 cites W1742769645 @default.
- W4384337998 cites W1752957211 @default.
- W4384337998 cites W1894685526 @default.
- W4384337998 cites W1912262500 @default.
- W4384337998 cites W1963617750 @default.
- W4384337998 cites W1965218665 @default.
- W4384337998 cites W1966052560 @default.
- W4384337998 cites W1973065326 @default.
- W4384337998 cites W1975820522 @default.
- W4384337998 cites W1977980568 @default.
- W4384337998 cites W1981743414 @default.
- W4384337998 cites W1981858801 @default.
- W4384337998 cites W1987481383 @default.
- W4384337998 cites W1997708871 @default.
- W4384337998 cites W1999070120 @default.
- W4384337998 cites W2002051393 @default.
- W4384337998 cites W2003210438 @default.
- W4384337998 cites W2006772331 @default.
- W4384337998 cites W2008471218 @default.
- W4384337998 cites W2008782348 @default.
- W4384337998 cites W2010562798 @default.
- W4384337998 cites W2014035331 @default.
- W4384337998 cites W2020744692 @default.
- W4384337998 cites W2021943943 @default.
- W4384337998 cites W2029184793 @default.
- W4384337998 cites W2029629696 @default.
- W4384337998 cites W2035041510 @default.
- W4384337998 cites W2035376519 @default.
- W4384337998 cites W2036380540 @default.
- W4384337998 cites W2036564362 @default.
- W4384337998 cites W2046205086 @default.
- W4384337998 cites W2046505430 @default.
- W4384337998 cites W2048793063 @default.
- W4384337998 cites W2049998759 @default.
- W4384337998 cites W2052641146 @default.
- W4384337998 cites W2056628849 @default.
- W4384337998 cites W2059604791 @default.
- W4384337998 cites W2066177626 @default.
- W4384337998 cites W2067420339 @default.
- W4384337998 cites W2078009629 @default.
- W4384337998 cites W2082216460 @default.
- W4384337998 cites W2083798679 @default.
- W4384337998 cites W2087166273 @default.
- W4384337998 cites W2088317975 @default.
- W4384337998 cites W2090685407 @default.
- W4384337998 cites W2091487793 @default.
- W4384337998 cites W2094504570 @default.
- W4384337998 cites W2095407765 @default.
- W4384337998 cites W2097748140 @default.
- W4384337998 cites W2101061654 @default.
- W4384337998 cites W2103153413 @default.
- W4384337998 cites W2105329191 @default.
- W4384337998 cites W2105606708 @default.
- W4384337998 cites W2108449579 @default.
- W4384337998 cites W2108765339 @default.
- W4384337998 cites W2111435630 @default.
- W4384337998 cites W2111932783 @default.
- W4384337998 cites W2115359896 @default.
- W4384337998 cites W2116332985 @default.
- W4384337998 cites W2127144270 @default.
- W4384337998 cites W2128305305 @default.
- W4384337998 cites W2132929600 @default.
- W4384337998 cites W2133019048 @default.
- W4384337998 cites W2134220401 @default.
- W4384337998 cites W2137670912 @default.
- W4384337998 cites W2142356948 @default.
- W4384337998 cites W2145034432 @default.
- W4384337998 cites W2150780552 @default.
- W4384337998 cites W2151369808 @default.
- W4384337998 cites W2161595265 @default.
- W4384337998 cites W2162125815 @default.
- W4384337998 cites W2164636847 @default.
- W4384337998 cites W2168400876 @default.
- W4384337998 cites W2168427724 @default.
- W4384337998 cites W2196638295 @default.
- W4384337998 cites W2338497436 @default.
- W4384337998 cites W2384868473 @default.
- W4384337998 cites W2412261015 @default.
- W4384337998 cites W2436945295 @default.
- W4384337998 cites W2519385241 @default.
- W4384337998 cites W2520191991 @default.
- W4384337998 cites W2535141202 @default.
- W4384337998 cites W2536675547 @default.
- W4384337998 cites W2549469016 @default.
- W4384337998 cites W2560238409 @default.
- W4384337998 cites W2567232760 @default.