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- W4384338441 abstract "Abstract Introduction: Psoriasis is an inflammatory skin disease. The objective of this study was to evaluate the effectiveness and efficacy of a natural topical cream and compare it with the gold-standard topical cream. Methodology: Randomized clinical trial, in 100 healthy volunteer subjects, five formulations of the new product were prepared and applied to 20 healthy subjects for each formulation. Of the 270 patients with psoriasis, 120 volunteer patients were selected; 60 patients were randomly administered the full natural product, and as a control group, 60 patients were treated with corticosteroid cream at the TMC Hospital. Outcome: Application in 100 healthy subjects showed that 99% had no side effects. When applied to patients with psoriasis at the TMC Hospital, the response was evaluated 10 days after treatment by comparing the results with a corticosteroid. Categorical variables are expressed as frequencies and percentages, and differences were analyzed using Pearson's chi-square test. Using Student’s t-test for paired tests, the differences before and after treatment between the medians of the continuous variables were analyzed and found to be significant. The distribution of the variables was analyzed using the nonparametric Mann-Whitney U test with the clinical variables, as well as with the PASI index and SBA, resulting in a highly significant P value of 0.000, which showed that the topical natural cream was effective in reducing the characteristic clinical signs in the skin of patients with psoriasis. Discussion: The application of the new natural cream with anti-inflammatory, exfoliating, soothing, disinfectant, antimicrobial, and healing properties showed that 99% of healthy subjects and patients had no side effects, presenting a rapid, statistically significant efficacy, whose results were compared with a topical corticosteroid 10 days after treatment. The new natural topical cream showed a remitting effect in the third month after the control. This cream was approved for commercialization in February 2023 by the Regulatory and Health Control Agency of Ecuador (ARCSA). As it is effective and efficient in patients with plaque psoriasis and its components are of natural origin, its application is recommended in this type of immunological disease whose improvement was clinically manifested from the beginning of the treatment." @default.
- W4384338441 created "2023-07-15" @default.
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- W4384338441 date "2023-07-14" @default.
- W4384338441 modified "2023-09-30" @default.
- W4384338441 title "Efficacy and Saffety of a Topical Natural Cream to Psoriasis: Randomized Clinical Trial" @default.
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- W4384338441 doi "https://doi.org/10.21203/rs.3.rs-3154469/v1" @default.
- W4384338441 hasPublicationYear "2023" @default.
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