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- W4384338575 endingPage "1562" @default.
- W4384338575 startingPage "1562" @default.
- W4384338575 abstract "Liver transplantation (LT) represents the primary curative option for HCC. Despite the extension of transplantation criteria and conversion with down-staging loco-regional treatments, transplantation is not always possible. The introduction of new standards of care in advanced HCC including a combination of immune checkpoint inhibitor-based therapies led to an improvement in response rates and could represent a promising strategy for down-staging the tumor burden. In this review, we identify reports and series, comprising a total of 43 patients who received immune checkpoint inhibitors as bridging or down-staging therapies prior to LT. Overall, treated patients registered an objective response rate of 21%, and 14 patients were reduced within the Milan criteria. Graft rejection was reported in seven patients, resulting in the death of four patients; in the remaining cases, LT was performed safely after immunotherapy. Further investigations are required to define the duration of immune checkpoint inhibitors, their minimum washout period and the LT long-term safety of this strategy. Some randomized clinical trials including immunotherapy combinations, loco-regional treatment and/or tyrosine kinase inhibitors are ongoing and will likely determine the appropriateness of immune checkpoint inhibitors’ administration before LT." @default.
- W4384338575 created "2023-07-15" @default.
- W4384338575 creator A5019141029 @default.
- W4384338575 creator A5036615333 @default.
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- W4384338575 creator A5078908501 @default.
- W4384338575 creator A5082066847 @default.
- W4384338575 creator A5086086808 @default.
- W4384338575 date "2023-07-14" @default.
- W4384338575 modified "2023-10-18" @default.
- W4384338575 title "Evolving Landscape in Liver Transplantation for Hepatocellular Carcinoma: From Stage Migration to Immunotherapy Revolution" @default.
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