Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384338640> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W4384338640 abstract "Abstract As societal aging intensifies, senile osteoporosis has become a global public health concern. Bone microdamage is mainly caused by processes such as enhancing osteoclast activity or reducing bone formation by osteoblast-lineage cells. Compared with young individuals, extracellular vesicles derived from senescent bone marrow mesenchymal stem cells(BMSCs) increase the transient differentiation of bone marrow monocytes (BMMs) to osteoclasts, ultimately leading to osteoporosis and metal implant failure. To address this daunting problem, an exosome-targeted orthopedic implant composed of a nutrient coating was developed. A high-zinc atmosphere used as a local microenvironmental cue could induce reprogramming of senile osteogenesis and osteoclast dialogue by exosome modification. Bidirectional regulation of intercellular communication via cargoes, including microRNAs carried by exosomes, was detected. Loss- and gain-of-function experiments demonstrated that the key regulator miR-146b-5p regulates the protein kinase B/mammalian target of rapamycin pathway by targeting the catalytic subunit gene of PI3K— PIK3CB. In vivo evaluation using a naturally-aged osteoporotic rat femoral defect model further confirmed that a nutrient coating substantially augments cancellous bone remodeling and osseointegration by regulating local BMMs differentiation. Altogether, this study not only reveals the close link between senescent stem cell communication and age-related osteoporosis but also provides a novel orthopedic implant for elderly patients with exosome modulation capability." @default.
- W4384338640 created "2023-07-15" @default.
- W4384338640 creator A5005701381 @default.
- W4384338640 creator A5006533811 @default.
- W4384338640 creator A5006625018 @default.
- W4384338640 creator A5036215036 @default.
- W4384338640 creator A5057560640 @default.
- W4384338640 creator A5057564694 @default.
- W4384338640 date "2023-07-14" @default.
- W4384338640 modified "2023-09-27" @default.
- W4384338640 title "Dominoes with interlocking consequences triggered by zinc: Involvement of microelement- stimulated MSC-derived small extracellular vesicles in senile osteogenesis and osteoclast dialogue" @default.
- W4384338640 cites W1964254026 @default.
- W4384338640 cites W2007165759 @default.
- W4384338640 cites W2134847038 @default.
- W4384338640 cites W2559809466 @default.
- W4384338640 cites W2779417942 @default.
- W4384338640 cites W2794995648 @default.
- W4384338640 cites W2808371154 @default.
- W4384338640 cites W2910258537 @default.
- W4384338640 cites W2977240403 @default.
- W4384338640 cites W2991532494 @default.
- W4384338640 cites W2996134710 @default.
- W4384338640 cites W3080541022 @default.
- W4384338640 cites W3081261750 @default.
- W4384338640 cites W3093572772 @default.
- W4384338640 cites W3125250500 @default.
- W4384338640 cites W3203490587 @default.
- W4384338640 cites W4224123640 @default.
- W4384338640 doi "https://doi.org/10.21203/rs.3.rs-3156990/v1" @default.
- W4384338640 hasPublicationYear "2023" @default.
- W4384338640 type Work @default.
- W4384338640 citedByCount "1" @default.
- W4384338640 countsByYear W43843386402023 @default.
- W4384338640 crossrefType "posted-content" @default.
- W4384338640 hasAuthorship W4384338640A5005701381 @default.
- W4384338640 hasAuthorship W4384338640A5006533811 @default.
- W4384338640 hasAuthorship W4384338640A5006625018 @default.
- W4384338640 hasAuthorship W4384338640A5036215036 @default.
- W4384338640 hasAuthorship W4384338640A5057560640 @default.
- W4384338640 hasAuthorship W4384338640A5057564694 @default.
- W4384338640 hasBestOaLocation W43843386401 @default.
- W4384338640 hasConcept C104317684 @default.
- W4384338640 hasConcept C134018914 @default.
- W4384338640 hasConcept C145059251 @default.
- W4384338640 hasConcept C170033053 @default.
- W4384338640 hasConcept C185592680 @default.
- W4384338640 hasConcept C198826908 @default.
- W4384338640 hasConcept C202751555 @default.
- W4384338640 hasConcept C20518536 @default.
- W4384338640 hasConcept C2776033226 @default.
- W4384338640 hasConcept C2776541429 @default.
- W4384338640 hasConcept C2778260815 @default.
- W4384338640 hasConcept C2781261824 @default.
- W4384338640 hasConcept C2908689518 @default.
- W4384338640 hasConcept C55493867 @default.
- W4384338640 hasConcept C86803240 @default.
- W4384338640 hasConcept C95444343 @default.
- W4384338640 hasConceptScore W4384338640C104317684 @default.
- W4384338640 hasConceptScore W4384338640C134018914 @default.
- W4384338640 hasConceptScore W4384338640C145059251 @default.
- W4384338640 hasConceptScore W4384338640C170033053 @default.
- W4384338640 hasConceptScore W4384338640C185592680 @default.
- W4384338640 hasConceptScore W4384338640C198826908 @default.
- W4384338640 hasConceptScore W4384338640C202751555 @default.
- W4384338640 hasConceptScore W4384338640C20518536 @default.
- W4384338640 hasConceptScore W4384338640C2776033226 @default.
- W4384338640 hasConceptScore W4384338640C2776541429 @default.
- W4384338640 hasConceptScore W4384338640C2778260815 @default.
- W4384338640 hasConceptScore W4384338640C2781261824 @default.
- W4384338640 hasConceptScore W4384338640C2908689518 @default.
- W4384338640 hasConceptScore W4384338640C55493867 @default.
- W4384338640 hasConceptScore W4384338640C86803240 @default.
- W4384338640 hasConceptScore W4384338640C95444343 @default.
- W4384338640 hasLocation W43843386401 @default.
- W4384338640 hasOpenAccess W4384338640 @default.
- W4384338640 hasPrimaryLocation W43843386401 @default.
- W4384338640 hasRelatedWork W2513456796 @default.
- W4384338640 hasRelatedWork W2549921596 @default.
- W4384338640 hasRelatedWork W2785527513 @default.
- W4384338640 hasRelatedWork W2955875101 @default.
- W4384338640 hasRelatedWork W3046776311 @default.
- W4384338640 hasRelatedWork W3087725815 @default.
- W4384338640 hasRelatedWork W3139087999 @default.
- W4384338640 hasRelatedWork W3198772284 @default.
- W4384338640 hasRelatedWork W4200367686 @default.
- W4384338640 hasRelatedWork W4353071466 @default.
- W4384338640 isParatext "false" @default.
- W4384338640 isRetracted "false" @default.
- W4384338640 workType "article" @default.