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• W4384339007 abstract "Nucleic acid sensing is a central process in the immune system, with far-reaching roles in antiviral defense, autoinflammation, and cancer. Z-DNA binding protein 1 (ZBP1) is a sensor for double-stranded DNA and RNA helices in the unusual left-handed Z conformation termed Z-DNA and Z-RNA. Recent research established ZBP1 as a key upstream regulator of cell death and proinflammatory signaling. Recognition of Z-DNA/RNA by ZBP1 promotes host resistance to viral infection but can also drive detrimental autoinflammation. Additionally, ZBP1 has interesting roles in cancer and other disease settings and is emerging as an attractive target for therapy." @default.
• W4384339007 created "2023-07-15" @default.
• W4384339007 creator A5078937992 @default.
• W4384339007 creator A5080842218 @default.
• W4384339007 date "2023-07-14" @default.
• W4384339007 modified "2023-10-04" @default.
• W4384339007 title "The Z-nucleic acid sensor ZBP1 in health and disease" @default.
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