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• W4384339102 startingPage "1565" @default.
• W4384339102 abstract "Compound K (CK) is one of the major metabolites found in mammalian blood and organs following oral administration of Panax plants. CK, also known as minor ginsenoside, can be absorbed in the systemic circulation. It has garnered significant attention in healthcare and medical products due to its pharmacological activities, such as antioxidation, anticancer, antiproliferation, antidiabetics, neuroprotection, and anti-atherogenic activities. However, CK is not found in natural ginseng plants but in traditional chemical synthesis, which uses toxic solvents and leads to environmental pollution during the harvest process. Moreover, enzymatic reactions are impractical for industrial CK production due to low yield and high costs. Although CK could be generated from major ginsenosides, most ginsenosides, including protopanaxatriol-oleanane and ocotillol-type, are not converted into CK by catalyzing β-glucosidase. Therefore, microbial cell systems have been used as a promising solution, providing a safe and efficient approach to CK production. This review provides a summary of various approaches for the production of CK, including chemical and enzymatic reactions, biotransformation by the human intestinal bacteria and endophytes as well as engineered microbes. Moreover, the approaches for CK production have been discussed to improve the productivity of target compounds." @default.
• W4384339102 created "2023-07-15" @default.
• W4384339102 creator A5018791659 @default.
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• W4384339102 creator A5057034593 @default.
• W4384339102 creator A5070372134 @default.
• W4384339102 date "2023-07-14" @default.
• W4384339102 modified "2023-09-28" @default.
• W4384339102 title "Compound K Production: Achievements and Perspectives" @default.
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