Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384340063> ?p ?o ?g. }
- W4384340063 abstract "Background Recent evidence implicates inflammation as a key driver in delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage (SAH). Inducible nitric oxide synthase (iNOS) is one of the known major mediators of inflammation. We previously showed that an inhalational anesthetic, isoflurane, provides strong protection against delayed cerebral ischemia after SAH. Our current study aims to define the role of iNOS in isoflurane conditioning-induced protection against delayed cerebral ischemia in a mouse model of SAH. Methods and Results The experiments used 10- to 14-week-old male wild-type (C57BL/6) and iNOS global knockout mice. Anesthetic conditioning was initiated 1 hour after SAH with isoflurane 2% for 1 hour. Isoflurane-induced changes in iNOS expression were measured. N-(3-(aminomethyl) benzyl) acetamidine, a highly selective iNOS inhibitor, was injected intraperitoneally immediately after SAH and then daily. Vasospasm, microvessel thrombosis, and neurological assessment was performed. Data were analyzed by 1-way ANOVA and 2-way repeated measures ANOVA followed by Student Newman Keuls comparison test. Statistical significance was set at P<0.05. Isoflurane conditioning downregulated iNOS expression in naïve and SAH mice. N-(3-(aminomethyl) benzyl) acetamidine attenuated large artery vasospasm and microvessel thrombosis and improved neurological deficits in wild-type animals. iNOS knockout mice were significantly resistant to vasospasm, microvessel thrombosis, and neurological deficits induced by SAH. Combining isoflurane with N-(3-(aminomethyl) benzyl) acetamidine did not offer extra protection, nor did treating iNOS knockout mice with isoflurane. Conclusions Isoflurane conditioning-induced delayed cerebral ischemia protection appears to be mediated by downregulating iNOS. iNOS is a potential therapeutic target to improve outcomes after SAH." @default.
- W4384340063 created "2023-07-15" @default.
- W4384340063 creator A5000048330 @default.
- W4384340063 creator A5005109737 @default.
- W4384340063 creator A5006541473 @default.
- W4384340063 creator A5018934813 @default.
- W4384340063 creator A5024387261 @default.
- W4384340063 creator A5028311110 @default.
- W4384340063 creator A5031492756 @default.
- W4384340063 creator A5034637646 @default.
- W4384340063 creator A5040295712 @default.
- W4384340063 creator A5051280959 @default.
- W4384340063 creator A5052248745 @default.
- W4384340063 date "2023-07-18" @default.
- W4384340063 modified "2023-10-05" @default.
- W4384340063 title "Isoflurane Conditioning‐Induced Delayed Cerebral Ischemia Protection in Subarachnoid Hemorrhage—Role of Inducible Nitric Oxide Synthase" @default.
- W4384340063 cites W1667686291 @default.
- W4384340063 cites W2005732901 @default.
- W4384340063 cites W2023319428 @default.
- W4384340063 cites W2040831177 @default.
- W4384340063 cites W2069843671 @default.
- W4384340063 cites W2141026681 @default.
- W4384340063 cites W2141793532 @default.
- W4384340063 cites W2142209099 @default.
- W4384340063 cites W2242760934 @default.
- W4384340063 cites W2290538778 @default.
- W4384340063 cites W2314523849 @default.
- W4384340063 cites W2401657437 @default.
- W4384340063 cites W2462649220 @default.
- W4384340063 cites W2951775644 @default.
- W4384340063 cites W3047879827 @default.
- W4384340063 cites W3081771677 @default.
- W4384340063 cites W3094142332 @default.
- W4384340063 cites W3153378702 @default.
- W4384340063 cites W3174854692 @default.
- W4384340063 cites W3178082043 @default.
- W4384340063 cites W4206215271 @default.
- W4384340063 cites W4225907544 @default.
- W4384340063 cites W4240178698 @default.
- W4384340063 cites W4240644295 @default.
- W4384340063 doi "https://doi.org/10.1161/jaha.123.029975" @default.
- W4384340063 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37449587" @default.
- W4384340063 hasPublicationYear "2023" @default.
- W4384340063 type Work @default.
- W4384340063 citedByCount "1" @default.
- W4384340063 countsByYear W43843400632023 @default.
- W4384340063 crossrefType "journal-article" @default.
- W4384340063 hasAuthorship W4384340063A5000048330 @default.
- W4384340063 hasAuthorship W4384340063A5005109737 @default.
- W4384340063 hasAuthorship W4384340063A5006541473 @default.
- W4384340063 hasAuthorship W4384340063A5018934813 @default.
- W4384340063 hasAuthorship W4384340063A5024387261 @default.
- W4384340063 hasAuthorship W4384340063A5028311110 @default.
- W4384340063 hasAuthorship W4384340063A5031492756 @default.
- W4384340063 hasAuthorship W4384340063A5034637646 @default.
- W4384340063 hasAuthorship W4384340063A5040295712 @default.
- W4384340063 hasAuthorship W4384340063A5051280959 @default.
- W4384340063 hasAuthorship W4384340063A5052248745 @default.
- W4384340063 hasBestOaLocation W43843400631 @default.
- W4384340063 hasConcept C126322002 @default.
- W4384340063 hasConcept C170493617 @default.
- W4384340063 hasConcept C182704531 @default.
- W4384340063 hasConcept C2776359302 @default.
- W4384340063 hasConcept C2777622882 @default.
- W4384340063 hasConcept C2777736543 @default.
- W4384340063 hasConcept C2778506911 @default.
- W4384340063 hasConcept C42219234 @default.
- W4384340063 hasConcept C519581460 @default.
- W4384340063 hasConcept C541997718 @default.
- W4384340063 hasConcept C71924100 @default.
- W4384340063 hasConcept C98274493 @default.
- W4384340063 hasConceptScore W4384340063C126322002 @default.
- W4384340063 hasConceptScore W4384340063C170493617 @default.
- W4384340063 hasConceptScore W4384340063C182704531 @default.
- W4384340063 hasConceptScore W4384340063C2776359302 @default.
- W4384340063 hasConceptScore W4384340063C2777622882 @default.
- W4384340063 hasConceptScore W4384340063C2777736543 @default.
- W4384340063 hasConceptScore W4384340063C2778506911 @default.
- W4384340063 hasConceptScore W4384340063C42219234 @default.
- W4384340063 hasConceptScore W4384340063C519581460 @default.
- W4384340063 hasConceptScore W4384340063C541997718 @default.
- W4384340063 hasConceptScore W4384340063C71924100 @default.
- W4384340063 hasConceptScore W4384340063C98274493 @default.
- W4384340063 hasIssue "14" @default.
- W4384340063 hasLocation W43843400631 @default.
- W4384340063 hasLocation W43843400632 @default.
- W4384340063 hasLocation W43843400633 @default.
- W4384340063 hasOpenAccess W4384340063 @default.
- W4384340063 hasPrimaryLocation W43843400631 @default.
- W4384340063 hasRelatedWork W2022018322 @default.
- W4384340063 hasRelatedWork W2050802868 @default.
- W4384340063 hasRelatedWork W2144052707 @default.
- W4384340063 hasRelatedWork W2170110115 @default.
- W4384340063 hasRelatedWork W2356255758 @default.
- W4384340063 hasRelatedWork W2358693179 @default.
- W4384340063 hasRelatedWork W2388981420 @default.
- W4384340063 hasRelatedWork W2413781940 @default.
- W4384340063 hasRelatedWork W3029055717 @default.
- W4384340063 hasRelatedWork W3094142332 @default.
- W4384340063 hasVolume "12" @default.