Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384340072> ?p ?o ?g. }
- W4384340072 endingPage "863" @default.
- W4384340072 startingPage "853" @default.
- W4384340072 abstract "Abstract Methionine synthases (MetH) catalyse the methylation of homocysteine (Hcy) with 5-methyl-tetrahydrofolate (5, methyl-THF) acting as methyl donor, to form methionine (Met) and tetrahydrofolate (THF). This function is performed by two unrelated classes of enzymes that differ significantly in both their structures and mechanisms of action. The genomes of plants and many fungi exclusively encode cobalamin-independent enzymes (EC.2.1.1.14), while some fungi also possess proteins from the cobalamin-dependent (EC.2.1.1.13) family utilised by humans. Methionine synthase’s function connects the methionine and folate cycles, making it a crucial node in primary metabolism, with impacts on important cellular processes such as anabolism, growth and synthesis of proteins, polyamines, nucleotides and lipids. As a result, MetHs are vital for the viability or virulence of numerous prominent human and plant pathogenic fungi and have been proposed as promising broad-spectrum antifungal drug targets. This review provides a summary of the relevance of methionine synthases to fungal metabolism, their potential as antifungal drug targets and insights into the structures of both classes of MetH." @default.
- W4384340072 created "2023-07-15" @default.
- W4384340072 creator A5010044780 @default.
- W4384340072 creator A5066056399 @default.
- W4384340072 date "2023-09-01" @default.
- W4384340072 modified "2023-09-26" @default.
- W4384340072 title "The role of methionine synthases in fungal metabolism and virulence" @default.
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