Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384341026> ?p ?o ?g. }
- W4384341026 abstract "The helper CD4+ T cell-type 17 (Th17) cells and regulatory CD4+ T cells (Tregs) are balanced through numerous molecular regulators, particularly metabolic factors, and their alteration causes immune dysregulation. Herein, we report that peroxisome proliferator of activated receptor-alpha (Pparα), a lipid metabolism regulator, suppresses Th17 differentiation. We demonstrated that Pparα ablation improves Th17 and pro-Th17 factor HIF-1α by enhancing the expression and nuclear localization of NFκB-activator IκB kinase-alpha (IKKα). Unexpectedly, we found that IKKα directly interacts with RORγt and enhances the expression of Il17a gene. Meanwhile, IKKα also interacts with Foxp3, leading to the post-translational regulation of Foxp3 by elevating its proteasomal degradation, and influencing Th17 development. Pparα deficiency leads to enhanced Th17 development in vivo and is associated with enhanced pathology in a murine experimental autoimmune encephalomyelitis (EAE) model. Overall, our data indicate that Pparα may serve as a potential therapeutic target for autoimmune and inflammatory diseases." @default.
- W4384341026 created "2023-07-15" @default.
- W4384341026 creator A5017987026 @default.
- W4384341026 creator A5023037940 @default.
- W4384341026 creator A5042876716 @default.
- W4384341026 creator A5062962051 @default.
- W4384341026 creator A5081507313 @default.
- W4384341026 date "2023-07-14" @default.
- W4384341026 modified "2023-09-25" @default.
- W4384341026 title "Pparα knockout in mice increases the Th17 development by facilitating the IKKα/RORγt and IKKα/Foxp3 complexes" @default.
- W4384341026 cites W1630171124 @default.
- W4384341026 cites W1725854756 @default.
- W4384341026 cites W1783790598 @default.
- W4384341026 cites W1920177513 @default.
- W4384341026 cites W1965671023 @default.
- W4384341026 cites W1967211333 @default.
- W4384341026 cites W1971874355 @default.
- W4384341026 cites W1980237439 @default.
- W4384341026 cites W1982776595 @default.
- W4384341026 cites W1985294654 @default.
- W4384341026 cites W1993764727 @default.
- W4384341026 cites W2004769493 @default.
- W4384341026 cites W2005139170 @default.
- W4384341026 cites W2014346117 @default.
- W4384341026 cites W2015663542 @default.
- W4384341026 cites W2021492010 @default.
- W4384341026 cites W2023307129 @default.
- W4384341026 cites W2028413210 @default.
- W4384341026 cites W2029383851 @default.
- W4384341026 cites W2033958147 @default.
- W4384341026 cites W2034435067 @default.
- W4384341026 cites W2035212410 @default.
- W4384341026 cites W2037433323 @default.
- W4384341026 cites W2041468556 @default.
- W4384341026 cites W2041544510 @default.
- W4384341026 cites W2043776488 @default.
- W4384341026 cites W2048657955 @default.
- W4384341026 cites W2054321620 @default.
- W4384341026 cites W2056402897 @default.
- W4384341026 cites W2059895383 @default.
- W4384341026 cites W2060523664 @default.
- W4384341026 cites W2064331238 @default.
- W4384341026 cites W2077492907 @default.
- W4384341026 cites W2077669090 @default.
- W4384341026 cites W2079999658 @default.
- W4384341026 cites W2091451666 @default.
- W4384341026 cites W2092345398 @default.
- W4384341026 cites W2094123336 @default.
- W4384341026 cites W2094990294 @default.
- W4384341026 cites W2096199583 @default.
- W4384341026 cites W2098100644 @default.
- W4384341026 cites W2104919278 @default.
- W4384341026 cites W2107752044 @default.
- W4384341026 cites W2113054788 @default.
- W4384341026 cites W2113345769 @default.
- W4384341026 cites W2116676186 @default.
- W4384341026 cites W2121145204 @default.
- W4384341026 cites W2124002196 @default.
- W4384341026 cites W2126538938 @default.
- W4384341026 cites W2126703922 @default.
- W4384341026 cites W2131371764 @default.
- W4384341026 cites W2131846297 @default.
- W4384341026 cites W2133737057 @default.
- W4384341026 cites W2134053452 @default.
- W4384341026 cites W2141314779 @default.
- W4384341026 cites W2142017607 @default.
- W4384341026 cites W2145753600 @default.
- W4384341026 cites W2150928170 @default.
- W4384341026 cites W2152014155 @default.
- W4384341026 cites W2157739158 @default.
- W4384341026 cites W2162873738 @default.
- W4384341026 cites W2164164239 @default.
- W4384341026 cites W2166268973 @default.
- W4384341026 cites W2167432954 @default.
- W4384341026 cites W2168977454 @default.
- W4384341026 cites W2740495409 @default.
- W4384341026 cites W2755181857 @default.
- W4384341026 cites W2772222670 @default.
- W4384341026 cites W2786055362 @default.
- W4384341026 cites W2981142893 @default.
- W4384341026 cites W3045298676 @default.
- W4384341026 cites W3083594184 @default.
- W4384341026 cites W3109056059 @default.
- W4384341026 doi "https://doi.org/10.1038/s42003-023-05104-6" @default.
- W4384341026 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37452099" @default.
- W4384341026 hasPublicationYear "2023" @default.
- W4384341026 type Work @default.
- W4384341026 citedByCount "0" @default.
- W4384341026 crossrefType "journal-article" @default.
- W4384341026 hasAuthorship W4384341026A5017987026 @default.
- W4384341026 hasAuthorship W4384341026A5023037940 @default.
- W4384341026 hasAuthorship W4384341026A5042876716 @default.
- W4384341026 hasAuthorship W4384341026A5062962051 @default.
- W4384341026 hasAuthorship W4384341026A5081507313 @default.
- W4384341026 hasBestOaLocation W43843410261 @default.
- W4384341026 hasConcept C100175707 @default.
- W4384341026 hasConcept C104317684 @default.
- W4384341026 hasConcept C170493617 @default.
- W4384341026 hasConcept C185592680 @default.
- W4384341026 hasConcept C187345961 @default.