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- W4384341106 endingPage "11418" @default.
- W4384341106 startingPage "11418" @default.
- W4384341106 abstract "Prostate cancer (PCa) has a distinct molecular signature, including characteristic chromosomal translocations, gene deletions and defective DNA damage repair mechanisms. One crucial pathway involved is homologous recombination deficiency (HRD) and it is found in almost 20% of metastatic castrate-resistant PCa (mCRPC). Inherited/germline mutations are associated with a hereditary predisposition to early PCa development and aggressive behavior. BRCA2, ATM and CHECK2 are the most frequently HRD-mutated genes. BRCA2-mutated tumors have unfavorable clinical and pathological characteristics, such as intraductal carcinoma. PARP inhibitors, due to the induction of synthetic lethality, have been therapeutically approved for mCRPC with HRD alterations. Mutations are detected in metastatic tissue, while a liquid biopsy is utilized during follow-up, recognizing acquired resistance mechanisms. The mismatch repair (MMR) pathway is another DNA repair mechanism implicated in carcinogenesis, although only 5% of metastatic PCa is affected. It is associated with aggressive disease. PD-1 inhibitors have been used in MMR-deficient tumors; thus, the MMR status should be tested in all metastatic PCa cases. A surrogate marker of defective DNA repair mechanisms is the tumor mutational burden. PDL-1 expression and intratumoral lymphocytes have ambivalent predictive value. Few experimental molecules have been so far proposed as potential biomarkers. Future research may further elucidate the role of DNA damage pathways in PCa, revealing new therapeutic targets and predictive biomarkers." @default.
- W4384341106 created "2023-07-15" @default.
- W4384341106 creator A5012012894 @default.
- W4384341106 creator A5047263805 @default.
- W4384341106 creator A5086432547 @default.
- W4384341106 date "2023-07-13" @default.
- W4384341106 modified "2023-09-30" @default.
- W4384341106 title "DNA Damage Repair Pathways in Prostate Cancer: A Narrative Review of Molecular Mechanisms, Emerging Biomarkers and Therapeutic Targets in Precision Oncology" @default.
- W4384341106 cites W1578291413 @default.
- W4384341106 cites W1857395915 @default.
- W4384341106 cites W1867819687 @default.
- W4384341106 cites W1907505672 @default.
- W4384341106 cites W1914128856 @default.
- W4384341106 cites W1967529520 @default.
- W4384341106 cites W1982488143 @default.
- W4384341106 cites W1989602328 @default.
- W4384341106 cites W1994987687 @default.
- W4384341106 cites W2011442347 @default.
- W4384341106 cites W2011957420 @default.
- W4384341106 cites W2018288024 @default.
- W4384341106 cites W2034066784 @default.
- W4384341106 cites W2038264173 @default.
- W4384341106 cites W2040657105 @default.
- W4384341106 cites W2042103604 @default.
- W4384341106 cites W2050658928 @default.
- W4384341106 cites W2059057685 @default.
- W4384341106 cites W2062254183 @default.
- W4384341106 cites W2075296303 @default.
- W4384341106 cites W2087481500 @default.
- W4384341106 cites W2096731080 @default.
- W4384341106 cites W2100125385 @default.
- W4384341106 cites W2107972234 @default.
- W4384341106 cites W2111097236 @default.
- W4384341106 cites W2120035070 @default.
- W4384341106 cites W2121863482 @default.
- W4384341106 cites W2124295966 @default.
- W4384341106 cites W2126623769 @default.
- W4384341106 cites W2132023729 @default.
- W4384341106 cites W2136077882 @default.
- W4384341106 cites W2138709172 @default.
- W4384341106 cites W2154546296 @default.
- W4384341106 cites W2156021518 @default.
- W4384341106 cites W2161112598 @default.
- W4384341106 cites W2180120860 @default.
- W4384341106 cites W2197921176 @default.
- W4384341106 cites W2235405584 @default.
- W4384341106 cites W2329160730 @default.
- W4384341106 cites W2338481957 @default.
- W4384341106 cites W2405329180 @default.
- W4384341106 cites W2413691910 @default.
- W4384341106 cites W2437423001 @default.
- W4384341106 cites W2463867199 @default.
- W4384341106 cites W2521999166 @default.
- W4384341106 cites W2524544980 @default.
- W4384341106 cites W2526607882 @default.
- W4384341106 cites W2560367415 @default.
- W4384341106 cites W2570660231 @default.
- W4384341106 cites W2572174216 @default.
- W4384341106 cites W2591840592 @default.
- W4384341106 cites W2607462299 @default.
- W4384341106 cites W2607665721 @default.
- W4384341106 cites W2743298940 @default.
- W4384341106 cites W2760942750 @default.
- W4384341106 cites W2765997836 @default.
- W4384341106 cites W2771697619 @default.
- W4384341106 cites W2783019516 @default.
- W4384341106 cites W2784618326 @default.
- W4384341106 cites W2787971554 @default.
- W4384341106 cites W2791911265 @default.
- W4384341106 cites W2794685427 @default.
- W4384341106 cites W2796494201 @default.
- W4384341106 cites W2799894585 @default.
- W4384341106 cites W2801085592 @default.
- W4384341106 cites W2802095881 @default.
- W4384341106 cites W2802306658 @default.
- W4384341106 cites W2806562834 @default.
- W4384341106 cites W2808021061 @default.
- W4384341106 cites W2887136529 @default.
- W4384341106 cites W2892128235 @default.
- W4384341106 cites W2896844652 @default.
- W4384341106 cites W2897547720 @default.
- W4384341106 cites W2900648754 @default.
- W4384341106 cites W2908503672 @default.
- W4384341106 cites W2908857416 @default.
- W4384341106 cites W2912702154 @default.
- W4384341106 cites W2914702052 @default.
- W4384341106 cites W2915582979 @default.
- W4384341106 cites W2915732659 @default.
- W4384341106 cites W2915944698 @default.
- W4384341106 cites W2938666135 @default.
- W4384341106 cites W2942814044 @default.
- W4384341106 cites W2944675676 @default.
- W4384341106 cites W2945137199 @default.
- W4384341106 cites W2945420825 @default.
- W4384341106 cites W2952112291 @default.
- W4384341106 cites W2954841573 @default.
- W4384341106 cites W2956054465 @default.
- W4384341106 cites W2964899132 @default.