FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384341333> ?p ?o ?g. }

• W4384341333 abstract "Steroid receptor coactivators (SRCs) comprise a family of three paralogous proteins commonly recruited by eukaryotic transcription factors. Each SRC harbors two tandem Per-ARNT-Sim (PAS) domains that are broadly distributed that bind small molecules and regulate interactions. Using computational docking, solution NMR, mass spectrometry, and molecular dynamics simulations, we show that the SRC1 PAS-B domain can bind to certain prostaglandins (PGs) either non-covalently to a surface that overlaps with the site used to engage transcription factors or covalently to a single, specific, conserved cysteine residue next to a solvent accessible hydrophobic pocket. This pocket is in proximity to the canonical transcription factor binding site, but on the opposite side of the domain, suggesting a potential mode of regulating transcriptional activator-coactivator interactions." @default.
• W4384341333 created "2023-07-15" @default.
• W4384341333 creator A5017749584 @default.
• W4384341333 creator A5021414072 @default.
• W4384341333 creator A5022552567 @default.
• W4384341333 creator A5078275156 @default.
• W4384341333 date "2023-07-13" @default.
• W4384341333 modified "2023-09-27" @default.
• W4384341333 title "Prostaglandins as Candidate Ligands for a Per-ARNT-Sim (PAS) Domain of Steroid Receptor Coactivator 1 (SRC1)" @default.
• W4384341333 cites W1976989643 @default.
• W4384341333 cites W1977156196 @default.
• W4384341333 cites W1980020952 @default.
• W4384341333 cites W2003777572 @default.
• W4384341333 cites W2050175422 @default.
• W4384341333 cites W2053479959 @default.
• W4384341333 cites W2059911068 @default.
• W4384341333 cites W2076165083 @default.
• W4384341333 cites W2103994532 @default.
• W4384341333 cites W2115273558 @default.
• W4384341333 cites W2118000816 @default.
• W4384341333 cites W2121019490 @default.
• W4384341333 cites W2122023734 @default.
• W4384341333 cites W2122591123 @default.
• W4384341333 cites W2125318012 @default.
• W4384341333 cites W2129935236 @default.
• W4384341333 cites W2136332525 @default.
• W4384341333 cites W2153819462 @default.
• W4384341333 cites W2160405880 @default.
• W4384341333 cites W2164210517 @default.
• W4384341333 cites W2169821755 @default.
• W4384341333 cites W2528294899 @default.
• W4384341333 cites W2606727285 @default.
• W4384341333 cites W2767005317 @default.
• W4384341333 cites W3027373116 @default.
• W4384341333 cites W4240789623 @default.
• W4384341333 cites W4284879194 @default.
• W4384341333 cites W4306923018 @default.
• W4384341333 cites W4362204104 @default.
• W4384341333 cites W2771020518 @default.
• W4384341333 doi "https://doi.org/10.1101/2023.07.13.548854" @default.
• W4384341333 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37502902" @default.
• W4384341333 hasPublicationYear "2023" @default.
• W4384341333 type Work @default.
• W4384341333 citedByCount "0" @default.
• W4384341333 crossrefType "posted-content" @default.
• W4384341333 hasAuthorship W4384341333A5017749584 @default.
• W4384341333 hasAuthorship W4384341333A5021414072 @default.
• W4384341333 hasAuthorship W4384341333A5022552567 @default.
• W4384341333 hasAuthorship W4384341333A5078275156 @default.
• W4384341333 hasBestOaLocation W43843413331 @default.
• W4384341333 hasConcept C104317684 @default.
• W4384341333 hasConcept C116186050 @default.
• W4384341333 hasConcept C138885662 @default.
• W4384341333 hasConcept C159110408 @default.
• W4384341333 hasConcept C179926584 @default.
• W4384341333 hasConcept C185592680 @default.
• W4384341333 hasConcept C195598365 @default.
• W4384341333 hasConcept C33594762 @default.
• W4384341333 hasConcept C41685203 @default.
• W4384341333 hasConcept C41895202 @default.
• W4384341333 hasConcept C45815257 @default.
• W4384341333 hasConcept C55493867 @default.
• W4384341333 hasConcept C71924100 @default.
• W4384341333 hasConcept C77445288 @default.
• W4384341333 hasConcept C86339819 @default.
• W4384341333 hasConcept C86803240 @default.
• W4384341333 hasConcept C95444343 @default.
• W4384341333 hasConceptScore W4384341333C104317684 @default.
• W4384341333 hasConceptScore W4384341333C116186050 @default.
• W4384341333 hasConceptScore W4384341333C138885662 @default.
• W4384341333 hasConceptScore W4384341333C159110408 @default.
• W4384341333 hasConceptScore W4384341333C179926584 @default.
• W4384341333 hasConceptScore W4384341333C185592680 @default.
• W4384341333 hasConceptScore W4384341333C195598365 @default.
• W4384341333 hasConceptScore W4384341333C33594762 @default.
• W4384341333 hasConceptScore W4384341333C41685203 @default.
• W4384341333 hasConceptScore W4384341333C41895202 @default.
• W4384341333 hasConceptScore W4384341333C45815257 @default.
• W4384341333 hasConceptScore W4384341333C55493867 @default.
• W4384341333 hasConceptScore W4384341333C71924100 @default.
• W4384341333 hasConceptScore W4384341333C77445288 @default.
• W4384341333 hasConceptScore W4384341333C86339819 @default.
• W4384341333 hasConceptScore W4384341333C86803240 @default.
• W4384341333 hasConceptScore W4384341333C95444343 @default.
• W4384341333 hasLocation W43843413331 @default.
• W4384341333 hasLocation W43843413332 @default.
• W4384341333 hasLocation W43843413333 @default.
• W4384341333 hasOpenAccess W4384341333 @default.
• W4384341333 hasPrimaryLocation W43843413331 @default.
• W4384341333 hasRelatedWork W1998383661 @default.
• W4384341333 hasRelatedWork W2014725324 @default.
• W4384341333 hasRelatedWork W2053590454 @default.
• W4384341333 hasRelatedWork W2068733538 @default.
• W4384341333 hasRelatedWork W2127532387 @default.
• W4384341333 hasRelatedWork W2142013281 @default.
• W4384341333 hasRelatedWork W2416977311 @default.
• W4384341333 hasRelatedWork W2504389210 @default.
• W4384341333 hasRelatedWork W4223896867 @default.
• W4384341333 hasRelatedWork W4384341333 @default.
• W4384341333 isParatext "false" @default.

• next