FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384341892> ?p ?o ?g. }

• W4384341892 endingPage "2643" @default.
• W4384341892 startingPage "2643" @default.
• W4384341892 abstract "Agastache urticifolia (Benth.) Kuntze (horsemint), Achillea millefolium L. (yarrow), and Perideridia gairdneri (Hook. & Arn.) Mathias (yampah) are native, culturally important plants that grow in the subalpine meadows of Montana. Analysis of the composition of essential oils extracted from these plants showed that the main components of essential oils obtained from flowers and leaves of A. urticifolia (designated as AUF/AUL) were menthone (2.7/25.7%), isomenthone (2.6/29.1%), pulegone (78.9/28.8%), and limonene (4.2/6.2%), whereas essential oils obtained from the inflorescence of A. millefolium (designated as AMI) were high in α-thujone (17.1%) and β-thujone (14.9%), 1,8-cineole (17.0%), camphor (13.0%), sabinene (7.0%), guaia-3,9-dien-11-ol (3.2%), and terpinen-4-ol (2.5%). Essential oils obtained from the inflorescence of P. gairdneri (designated as PGI) contained high amounts of dillapiole (30.3%), p-cymen-8-ol (14.1%), terpinolene (12.0%), 4-hydroxy-4-methyl-cyclohex-2-enone (6.2%), and γ-terpinene (2.4%). Evaluation of their immunomodulatory activity demonstrated that essential oils extracted from all of these plants could activate human neutrophils with varying efficacy. Analysis of individual components showed that dillapiole activated human neutrophil intracellular Ca2+ flux ([Ca2+]i) (EC50 = 19.3 ± 1.4 μM), while α-thujone, β-thujone, menthone, isomenthone, and pulegone were inactive. Since dillapiole activated neutrophils, we also evaluated if it was able to down-regulate neutrophil responses to subsequent agonist activation and found that pretreatment with dillapiole inhibited neutrophil activation by the chemoattractant fMLF (IC50 = 34.3 ± 2.1 μM). Pretreatment with P. gairdneri essential oil or dillapiole also inhibited neutrophil chemotaxis induced by fMLF, suggesting these treatments could down-regulate human neutrophil responses to inflammatory chemoattractants. Thus, dillapiole may be a novel modulator of human neutrophil function." @default.
• W4384341892 created "2023-07-15" @default.
• W4384341892 creator A5006542271 @default.
• W4384341892 creator A5013186412 @default.
• W4384341892 creator A5043706974 @default.
• W4384341892 creator A5076540388 @default.
• W4384341892 creator A5077189123 @default.
• W4384341892 creator A5081850808 @default.
• W4384341892 creator A5085915839 @default.
• W4384341892 date "2023-07-14" @default.
• W4384341892 modified "2023-10-15" @default.
• W4384341892 title "Composition and Biological Activity of the Essential Oils from Wild Horsemint, Yarrow, and Yampah from Subalpine Meadows in Southwestern Montana: Immunomodulatory Activity of Dillapiole" @default.
• W4384341892 cites W1637554531 @default.
• W4384341892 cites W1745992392 @default.
• W4384341892 cites W1986450451 @default.
• W4384341892 cites W1994448537 @default.
• W4384341892 cites W2002403890 @default.
• W4384341892 cites W2020969008 @default.
• W4384341892 cites W2025114395 @default.
• W4384341892 cites W2055438060 @default.
• W4384341892 cites W2061358034 @default.
• W4384341892 cites W2061555681 @default.
• W4384341892 cites W2067034033 @default.
• W4384341892 cites W2076880895 @default.
• W4384341892 cites W2079788340 @default.
• W4384341892 cites W2082933728 @default.
• W4384341892 cites W2093687545 @default.
• W4384341892 cites W2103372863 @default.
• W4384341892 cites W2111733155 @default.
• W4384341892 cites W2127150951 @default.
• W4384341892 cites W2154953890 @default.
• W4384341892 cites W2403159911 @default.
• W4384341892 cites W2412073957 @default.
• W4384341892 cites W2475804996 @default.
• W4384341892 cites W2507148814 @default.
• W4384341892 cites W2584402451 @default.
• W4384341892 cites W2593436234 @default.
• W4384341892 cites W2616461709 @default.
• W4384341892 cites W2624931236 @default.
• W4384341892 cites W2913408298 @default.
• W4384341892 cites W2961671687 @default.
• W4384341892 cites W2986254559 @default.
• W4384341892 cites W3036843808 @default.
• W4384341892 cites W3046512345 @default.
• W4384341892 cites W3107014585 @default.
• W4384341892 cites W3171536183 @default.
• W4384341892 cites W3193679168 @default.
• W4384341892 cites W4200002789 @default.
• W4384341892 cites W4221099297 @default.
• W4384341892 cites W4281487163 @default.
• W4384341892 cites W4282582191 @default.
• W4384341892 cites W4285010734 @default.
• W4384341892 cites W4285498785 @default.
• W4384341892 cites W4289204361 @default.
• W4384341892 cites W4309742770 @default.
• W4384341892 cites W4311283663 @default.
• W4384341892 cites W4322630275 @default.
• W4384341892 cites W93284168 @default.
• W4384341892 doi "https://doi.org/10.3390/plants12142643" @default.
• W4384341892 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37514257" @default.
• W4384341892 hasPublicationYear "2023" @default.
• W4384341892 type Work @default.
• W4384341892 citedByCount "1" @default.
• W4384341892 countsByYear W43843418922023 @default.
• W4384341892 crossrefType "journal-article" @default.
• W4384341892 hasAuthorship W4384341892A5006542271 @default.
• W4384341892 hasAuthorship W4384341892A5013186412 @default.
• W4384341892 hasAuthorship W4384341892A5043706974 @default.
• W4384341892 hasAuthorship W4384341892A5076540388 @default.
• W4384341892 hasAuthorship W4384341892A5077189123 @default.
• W4384341892 hasAuthorship W4384341892A5081850808 @default.
• W4384341892 hasAuthorship W4384341892A5085915839 @default.
• W4384341892 hasBestOaLocation W43843418921 @default.
• W4384341892 hasConcept C178790620 @default.
• W4384341892 hasConcept C185592680 @default.
• W4384341892 hasConcept C2776134268 @default.
• W4384341892 hasConcept C2777278459 @default.
• W4384341892 hasConcept C2777861070 @default.
• W4384341892 hasConcept C2778829202 @default.
• W4384341892 hasConcept C2778919576 @default.
• W4384341892 hasConcept C2780697445 @default.
• W4384341892 hasConcept C59822182 @default.
• W4384341892 hasConcept C86803240 @default.
• W4384341892 hasConceptScore W4384341892C178790620 @default.
• W4384341892 hasConceptScore W4384341892C185592680 @default.
• W4384341892 hasConceptScore W4384341892C2776134268 @default.
• W4384341892 hasConceptScore W4384341892C2777278459 @default.
• W4384341892 hasConceptScore W4384341892C2777861070 @default.
• W4384341892 hasConceptScore W4384341892C2778829202 @default.
• W4384341892 hasConceptScore W4384341892C2778919576 @default.
• W4384341892 hasConceptScore W4384341892C2780697445 @default.
• W4384341892 hasConceptScore W4384341892C59822182 @default.
• W4384341892 hasConceptScore W4384341892C86803240 @default.
• W4384341892 hasFunder F4320306114 @default.
• W4384341892 hasFunder F4320313922 @default.
• W4384341892 hasFunder F4320332161 @default.
• W4384341892 hasIssue "14" @default.
• W4384341892 hasLocation W43843418921 @default.

• next