Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384342275> ?p ?o ?g. }
- W4384342275 endingPage "10531" @default.
- W4384342275 startingPage "10521" @default.
- W4384342275 abstract "Studies concerning the toxicity of pollutant-loaded nanoplastics (NPs) toward humans are still in their infancy. Here, we evaluated the adsorption of microcystins (MCs) by pristine and aged polystyrene nanoplastics (PSNPs), prepared MCs-loaded aged PSNPS (1, 5, 10, 15, and 19 μg/mg), and systematically mapped the key molecular changes induced by aged and MCs-loaded PSNPs to human hepatoblastoma (HepG2) cells. According to the results, MC-LR adsorption is increased 2.64-fold by aging, and PSNP accumulation is detected in HepG2 cells. The cytotoxicity of the MC-LR-loaded aged PSNPs showed a positive relationship with the MC-LR amount, as the cell viability in the 19 μg/mg loading treatment (aPS-MC19) was 10.84% lower than aged PSNPs; meanwhile, more severe oxidative damage was observed. Primary approaches involved stressing the endoplasmic reticulum and reducing protein synthesis that the aged PSNPs posed for HepG2 cells, while the aggravated cytotoxicity in aPS-MC19 treatment was a combined result of the metabolic energy disorder, oxidative damage, endoplasmic reticulum stress, and downregulation of the MC-LR target protein. Our results confirm that the aged PSNPs could bring more MC-LR into the HepG2 cells, significantly interfere with biological processes, and provide new insight into deciphering the risk of NPs to humans." @default.
- W4384342275 created "2023-07-15" @default.
- W4384342275 creator A5006793133 @default.
- W4384342275 creator A5030642909 @default.
- W4384342275 creator A5061817663 @default.
- W4384342275 creator A5063005534 @default.
- W4384342275 creator A5091598293 @default.
- W4384342275 creator A5091899500 @default.
- W4384342275 creator A5025078581 @default.
- W4384342275 date "2023-07-14" @default.
- W4384342275 modified "2023-10-17" @default.
- W4384342275 title "Microcystins-Loaded Aged Nanoplastics Provoke a Metabolic Shift in Human Liver Cells" @default.
- W4384342275 cites W1970207313 @default.
- W4384342275 cites W2021474866 @default.
- W4384342275 cites W2057325481 @default.
- W4384342275 cites W2069076161 @default.
- W4384342275 cites W2778228894 @default.
- W4384342275 cites W2781746339 @default.
- W4384342275 cites W2902993376 @default.
- W4384342275 cites W2910730299 @default.
- W4384342275 cites W2953942216 @default.
- W4384342275 cites W2972186294 @default.
- W4384342275 cites W2994137301 @default.
- W4384342275 cites W3000741318 @default.
- W4384342275 cites W3007086960 @default.
- W4384342275 cites W3010972983 @default.
- W4384342275 cites W3011433622 @default.
- W4384342275 cites W3012553779 @default.
- W4384342275 cites W3013906782 @default.
- W4384342275 cites W3039916318 @default.
- W4384342275 cites W3041663114 @default.
- W4384342275 cites W3087406616 @default.
- W4384342275 cites W3092390872 @default.
- W4384342275 cites W3093355009 @default.
- W4384342275 cites W3096102243 @default.
- W4384342275 cites W3132250580 @default.
- W4384342275 cites W3133571856 @default.
- W4384342275 cites W3139155470 @default.
- W4384342275 cites W3160238148 @default.
- W4384342275 cites W3171889036 @default.
- W4384342275 cites W3174455902 @default.
- W4384342275 cites W3192108090 @default.
- W4384342275 cites W3194896114 @default.
- W4384342275 cites W3203937064 @default.
- W4384342275 cites W3205349923 @default.
- W4384342275 cites W3210712229 @default.
- W4384342275 cites W3213435482 @default.
- W4384342275 cites W3213971824 @default.
- W4384342275 cites W3216861533 @default.
- W4384342275 cites W4205657434 @default.
- W4384342275 cites W4206777390 @default.
- W4384342275 cites W4214668543 @default.
- W4384342275 cites W4220670889 @default.
- W4384342275 cites W4220773999 @default.
- W4384342275 cites W4220840764 @default.
- W4384342275 cites W4224287120 @default.
- W4384342275 cites W4281815206 @default.
- W4384342275 cites W4282968406 @default.
- W4384342275 cites W4285499104 @default.
- W4384342275 cites W4288426979 @default.
- W4384342275 cites W4293104570 @default.
- W4384342275 cites W4296124661 @default.
- W4384342275 cites W4308389598 @default.
- W4384342275 cites W4308499098 @default.
- W4384342275 cites W4309329101 @default.
- W4384342275 cites W4309405290 @default.
- W4384342275 cites W4311127795 @default.
- W4384342275 cites W4313252804 @default.
- W4384342275 cites W4317933905 @default.
- W4384342275 cites W4319791863 @default.
- W4384342275 cites W4362521316 @default.
- W4384342275 doi "https://doi.org/10.1021/acs.est.3c00990" @default.
- W4384342275 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37449315" @default.
- W4384342275 hasPublicationYear "2023" @default.
- W4384342275 type Work @default.
- W4384342275 citedByCount "0" @default.
- W4384342275 crossrefType "journal-article" @default.
- W4384342275 hasAuthorship W4384342275A5006793133 @default.
- W4384342275 hasAuthorship W4384342275A5025078581 @default.
- W4384342275 hasAuthorship W4384342275A5030642909 @default.
- W4384342275 hasAuthorship W4384342275A5061817663 @default.
- W4384342275 hasAuthorship W4384342275A5063005534 @default.
- W4384342275 hasAuthorship W4384342275A5091598293 @default.
- W4384342275 hasAuthorship W4384342275A5091899500 @default.
- W4384342275 hasConcept C109316439 @default.
- W4384342275 hasConcept C158617107 @default.
- W4384342275 hasConcept C185592680 @default.
- W4384342275 hasConcept C202751555 @default.
- W4384342275 hasConcept C2776151105 @default.
- W4384342275 hasConcept C55493867 @default.
- W4384342275 hasConcept C86803240 @default.
- W4384342275 hasConcept C95444343 @default.
- W4384342275 hasConceptScore W4384342275C109316439 @default.
- W4384342275 hasConceptScore W4384342275C158617107 @default.
- W4384342275 hasConceptScore W4384342275C185592680 @default.
- W4384342275 hasConceptScore W4384342275C202751555 @default.
- W4384342275 hasConceptScore W4384342275C2776151105 @default.
- W4384342275 hasConceptScore W4384342275C55493867 @default.