Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384342892> ?p ?o ?g. }
- W4384342892 endingPage "19" @default.
- W4384342892 startingPage "1" @default.
- W4384342892 abstract "The emergence of new viruses can lead to the outbreak of pandemics as occurred at the end of 2019 with the coronavirus disease (or COVID-19). The fastest way to effectively control viral infections is to develop broad-spectrum antivirals that can fight at least an entire class of viruses. Profurin, the furin precursor propeptide, is responsible for the autoactivation step which is crucial for the maturation of several viral substrates. This role makes the study of furin and profurin interactions interesting for the development of new potential broad-spectrum antivirals for the treatment against several human viral diseases. Since there is no 3D model of profurin published in the literature or deposited in a database, this work reports the development, validation and analysis of a profurin 3D model using comparative modeling and molecular dynamics. The model is available in ModelArchive at https://www.modelarchive.org/doi/10.5452/ma-ct8l7. The usage of this model will make possible further studies of molecular docking and MD simulations of the profurin-furin system, in the design of new potential broad-spectrum antivirals for the treatment against several human viral diseases.Communicated by Ramaswamy H. Sarma" @default.
- W4384342892 created "2023-07-15" @default.
- W4384342892 creator A5059316660 @default.
- W4384342892 creator A5061800158 @default.
- W4384342892 creator A5067395751 @default.
- W4384342892 date "2023-07-14" @default.
- W4384342892 modified "2023-10-15" @default.
- W4384342892 title "Development, validation and analysis of a human profurin 3D model using comparative modeling and molecular dynamics simulations" @default.
- W4384342892 cites W1031578623 @default.
- W4384342892 cites W1491824558 @default.
- W4384342892 cites W1966491286 @default.
- W4384342892 cites W1969234902 @default.
- W4384342892 cites W1974043792 @default.
- W4384342892 cites W1976499671 @default.
- W4384342892 cites W1986191025 @default.
- W4384342892 cites W1989031499 @default.
- W4384342892 cites W1999613945 @default.
- W4384342892 cites W2001364008 @default.
- W4384342892 cites W2011301426 @default.
- W4384342892 cites W2025625972 @default.
- W4384342892 cites W2027408247 @default.
- W4384342892 cites W2029667189 @default.
- W4384342892 cites W2050333027 @default.
- W4384342892 cites W2054113344 @default.
- W4384342892 cites W2054881399 @default.
- W4384342892 cites W2055043387 @default.
- W4384342892 cites W2055441798 @default.
- W4384342892 cites W2057477511 @default.
- W4384342892 cites W2058341758 @default.
- W4384342892 cites W2060872117 @default.
- W4384342892 cites W2064081169 @default.
- W4384342892 cites W2064388657 @default.
- W4384342892 cites W2064987795 @default.
- W4384342892 cites W2067174909 @default.
- W4384342892 cites W2069123478 @default.
- W4384342892 cites W2070427583 @default.
- W4384342892 cites W2074231493 @default.
- W4384342892 cites W2081693079 @default.
- W4384342892 cites W2087590478 @default.
- W4384342892 cites W2102993309 @default.
- W4384342892 cites W2109154308 @default.
- W4384342892 cites W2125977924 @default.
- W4384342892 cites W2127322768 @default.
- W4384342892 cites W2128572087 @default.
- W4384342892 cites W2130479394 @default.
- W4384342892 cites W2130541969 @default.
- W4384342892 cites W2132589721 @default.
- W4384342892 cites W2144288821 @default.
- W4384342892 cites W2147443001 @default.
- W4384342892 cites W2154714625 @default.
- W4384342892 cites W2170711116 @default.
- W4384342892 cites W2171268876 @default.
- W4384342892 cites W2288425717 @default.
- W4384342892 cites W2292301738 @default.
- W4384342892 cites W2295124130 @default.
- W4384342892 cites W2411580022 @default.
- W4384342892 cites W2415698324 @default.
- W4384342892 cites W253094825 @default.
- W4384342892 cites W2765322245 @default.
- W4384342892 cites W2848394380 @default.
- W4384342892 cites W2899443929 @default.
- W4384342892 cites W2916965102 @default.
- W4384342892 cites W2938574745 @default.
- W4384342892 cites W2965830542 @default.
- W4384342892 cites W2971662549 @default.
- W4384342892 cites W2981642047 @default.
- W4384342892 cites W3003217347 @default.
- W4384342892 cites W3099878876 @default.
- W4384342892 cites W3100571307 @default.
- W4384342892 cites W3112376646 @default.
- W4384342892 cites W3150635270 @default.
- W4384342892 cites W3193536562 @default.
- W4384342892 cites W4210596565 @default.
- W4384342892 cites W4211196614 @default.
- W4384342892 doi "https://doi.org/10.1080/07391102.2023.2231546" @default.
- W4384342892 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37449759" @default.
- W4384342892 hasPublicationYear "2023" @default.
- W4384342892 type Work @default.
- W4384342892 citedByCount "0" @default.
- W4384342892 crossrefType "journal-article" @default.
- W4384342892 hasAuthorship W4384342892A5059316660 @default.
- W4384342892 hasAuthorship W4384342892A5061800158 @default.
- W4384342892 hasAuthorship W4384342892A5067395751 @default.
- W4384342892 hasConcept C142724271 @default.
- W4384342892 hasConcept C159047783 @default.
- W4384342892 hasConcept C159110408 @default.
- W4384342892 hasConcept C181199279 @default.
- W4384342892 hasConcept C185592680 @default.
- W4384342892 hasConcept C21951064 @default.
- W4384342892 hasConcept C2777265534 @default.
- W4384342892 hasConcept C2779134260 @default.
- W4384342892 hasConcept C3008058167 @default.
- W4384342892 hasConcept C3020442560 @default.
- W4384342892 hasConcept C41008148 @default.
- W4384342892 hasConcept C41685203 @default.
- W4384342892 hasConcept C524204448 @default.
- W4384342892 hasConcept C55493867 @default.
- W4384342892 hasConcept C70721500 @default.