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- W4384343344 abstract "Objective To evaluate the efficacy of automatic oxygen control (A-FiO 2 ) in reducing the extremes of oxygen saturations (SpO 2 <80% and SpO 2 >98%) in preterm infants on high-flow nasal cannula (HFNC) respiratory support using Vapotherm Precision Flow. Design A parallel-arm randomised controlled trial. Setting A level-III neonatal intensive care unit. Patients Preterm infants born <33 (23+0 to 32+6) weeks receiving HFNC as respiratory support. Interventions A-FiO 2 versus manual (M-FiO 2 ) oxygen control during the full course of HFNC support. Outcomes The primary outcome of this study is percentage of time spent in extreme oxygen saturations (<80% and >98%) in preterm infants when receiving HFNC as respiratory support. Secondary outcomes were time with SpO 2 between 90% and 95% plus time >95% without supplemental oxygen. Results 60 infants were randomised equally to either A-FiO 2 or M-FiO 2 arm. Their baseline characteristics were comparable. They spent a median of 5.3 (IQR: 2.0–8.4) and 6.5 (IQR: 2.9–13.7) days in the study, A-FiO 2 and M-FiO 2 , respectively. The percentage of time spent in SpO 2 <80% (median of 0.4% (0.1%–0.8%) vs 1.6% (0.6%–2.6%), p=0.002) and >98% (median 0.2% (0.1%–0.9%) vs 1.9% (0.7%–4%), p<0.001) were significantly lower in A-FiO 2 compared with M-FiO 2 . The difference in median percentage of time in target range between the two arms was 26% (81% (74%–93%) in A-FiO 2 vs 55% (48%–72%) in M-FiO 2 ). Conclusion A-FiO 2 was associated with statistically significant reduction in the percentage of time spent in extremes of saturation when compared with M-FiO 2 in preterm infants receiving HFNC. Trial registration number NCT04687618 ." @default.
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- W4384343344 date "2023-07-14" @default.
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- W4384343344 title "Randomised control trial of oxygen assist module in preterm infants on high-flow nasal cannula support" @default.
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- W4384343344 doi "https://doi.org/10.1136/archdischild-2023-325661" @default.
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