Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384343411> ?p ?o ?g. }
- W4384343411 abstract "Abstract Our study utilizes a longitudinal isotopic metabolic labeling approach in vivo in combination with organelle fraction proteomics to address the role of parkin in mitochondrial protein turnover in mice. The use of metabolic labeling provides a method to quantitatively determine the global changes in protein half-lives whilst simultaneously assessing protein expression. Studying two diverse mitochondrial populations, we demonstrated the median half-life of brain striatal synaptic mitochondrial proteins is significantly greater than that of hepatic mitochondrial proteins (25.7 vs. 3.5 days). Furthermore, loss of parkin resulted in an overall, albeit modest, increase in both mitochondrial protein abundance and half-life. Pathway and functional analysis of our proteomics data identified both known and novel pathways affected by loss of parkin that are consistent with its role in both mitochondrial quality control and neurodegeneration. Our study therefore adds to a growing body of evidence suggesting dependence on parkin is low for basal mitophagy in vivo and provides a foundation for the investigation of novel parkin targets." @default.
- W4384343411 created "2023-07-15" @default.
- W4384343411 creator A5028531237 @default.
- W4384343411 creator A5030467909 @default.
- W4384343411 creator A5051575971 @default.
- W4384343411 creator A5060950419 @default.
- W4384343411 creator A5061418721 @default.
- W4384343411 creator A5063173274 @default.
- W4384343411 creator A5077965562 @default.
- W4384343411 date "2023-07-14" @default.
- W4384343411 modified "2023-10-14" @default.
- W4384343411 title "Longitudinal in vivo metabolic labeling reveals tissue-specific mitochondrial proteome turnover rates and proteins selectively altered by parkin deficiency" @default.
- W4384343411 cites W1045058699 @default.
- W4384343411 cites W1480927111 @default.
- W4384343411 cites W1579119691 @default.
- W4384343411 cites W1728360557 @default.
- W4384343411 cites W1867998771 @default.
- W4384343411 cites W1918185049 @default.
- W4384343411 cites W1962054249 @default.
- W4384343411 cites W1964244550 @default.
- W4384343411 cites W1968276382 @default.
- W4384343411 cites W1970095022 @default.
- W4384343411 cites W1970847194 @default.
- W4384343411 cites W1982259828 @default.
- W4384343411 cites W1989026904 @default.
- W4384343411 cites W1991486160 @default.
- W4384343411 cites W2000891784 @default.
- W4384343411 cites W2011124366 @default.
- W4384343411 cites W2012034410 @default.
- W4384343411 cites W2012717721 @default.
- W4384343411 cites W2015758704 @default.
- W4384343411 cites W2016019423 @default.
- W4384343411 cites W2018603142 @default.
- W4384343411 cites W2024668145 @default.
- W4384343411 cites W2035787181 @default.
- W4384343411 cites W2038976751 @default.
- W4384343411 cites W2043790670 @default.
- W4384343411 cites W2052889619 @default.
- W4384343411 cites W2053943711 @default.
- W4384343411 cites W2057545775 @default.
- W4384343411 cites W2057852669 @default.
- W4384343411 cites W2058952332 @default.
- W4384343411 cites W2059577301 @default.
- W4384343411 cites W2061768322 @default.
- W4384343411 cites W2065515412 @default.
- W4384343411 cites W2069931528 @default.
- W4384343411 cites W2071388148 @default.
- W4384343411 cites W2076769172 @default.
- W4384343411 cites W2077986468 @default.
- W4384343411 cites W2080752012 @default.
- W4384343411 cites W2081538536 @default.
- W4384343411 cites W2083252150 @default.
- W4384343411 cites W2084797262 @default.
- W4384343411 cites W2085975745 @default.
- W4384343411 cites W2088962120 @default.
- W4384343411 cites W2089273345 @default.
- W4384343411 cites W2095323303 @default.
- W4384343411 cites W2105838740 @default.
- W4384343411 cites W2118479885 @default.
- W4384343411 cites W2120521594 @default.
- W4384343411 cites W2120865735 @default.
- W4384343411 cites W2133465414 @default.
- W4384343411 cites W2133727193 @default.
- W4384343411 cites W2139425547 @default.
- W4384343411 cites W2140422012 @default.
- W4384343411 cites W2140647923 @default.
- W4384343411 cites W2142957480 @default.
- W4384343411 cites W2143906078 @default.
- W4384343411 cites W2152817972 @default.
- W4384343411 cites W2158217645 @default.
- W4384343411 cites W2162143298 @default.
- W4384343411 cites W2170457695 @default.
- W4384343411 cites W2284559545 @default.
- W4384343411 cites W2330299721 @default.
- W4384343411 cites W2335833703 @default.
- W4384343411 cites W2463195069 @default.
- W4384343411 cites W2466261603 @default.
- W4384343411 cites W2530626079 @default.
- W4384343411 cites W2544360569 @default.
- W4384343411 cites W2551880155 @default.
- W4384343411 cites W2592518050 @default.
- W4384343411 cites W2730255373 @default.
- W4384343411 cites W2783409125 @default.
- W4384343411 cites W2787965853 @default.
- W4384343411 cites W2791640311 @default.
- W4384343411 cites W2796329698 @default.
- W4384343411 cites W2810506792 @default.
- W4384343411 cites W2890004445 @default.
- W4384343411 cites W2900687171 @default.
- W4384343411 cites W2903973081 @default.
- W4384343411 cites W2905766113 @default.
- W4384343411 cites W2918580443 @default.
- W4384343411 cites W2926307397 @default.
- W4384343411 cites W2943174094 @default.
- W4384343411 cites W2945896312 @default.
- W4384343411 cites W2946387919 @default.
- W4384343411 cites W2947325374 @default.
- W4384343411 cites W2949566851 @default.
- W4384343411 cites W2955142300 @default.
- W4384343411 cites W2964710778 @default.