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- W4384343452 abstract "As a species tightly associated with inflammation, superoxide anion radical (O2·-) is generally recognized a biomarker for interstitial cystitis (IC) but the reliable detection of such species has been remaining a challenge owing to its elusive nature. Herein, we developed a merocyanine dye-based fluorescent probe, MC-O-TBS, capable of detecting O2·- species with a limit of detection down to 49.3 nM, recognition specificity against other potential interfering species and two-photon excitation fluorescence (TPEF) property for bioimaging with satisfactory depth. As another particularly salient feature, MC-O-TBS generates O2·--mediated fluorescence contrast with response time less than 10 s, an unexampled response agility of probe in O2·- fluorescence sensing as compared to the counterpart probes developed to date. The superior performance of MC-O-TBS probe in terms of recognition specificity, detection sensitivity, TPEF for bioimaging with satisfactory depth and response rate as well as the preliminary in vitro experiment results regarding mapping O2− level in bladder organ unequivocally proclaimed its potential for reliably monitoring the highly elusive O2− species and clinically diagnosing IC featured with abnormal O2− level." @default.
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- W4384343452 date "2023-11-01" @default.
- W4384343452 modified "2023-09-26" @default.
- W4384343452 title "A merocyanine dye-based superoxide anion fluorescent probe with second-level response agility enables evaluating interstitial cystitis via two-photon excitation imaging" @default.
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- W4384343452 doi "https://doi.org/10.1016/j.dyepig.2023.111526" @default.
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