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- W4384343602 endingPage "e18295" @default.
- W4384343602 startingPage "e18295" @default.
- W4384343602 abstract "This study evaluated the effects of different parts of M. paniculata (MP) extracts on convulsions and antioxidant activities in mice. Six polyphenolic compounds were identified, where epicatechin and quercetin have been identified in the highest amounts (23.01 and 32.23 mg/100 g of dry MP extract, respectively) in MP leaf and stem extracts, using Ultra Performance Liquid Chromatography. 7-day oral administration of MP at doses of 100, 200, and 400 mg/kg body weight (BW) significantly reduced convulsions and reduced mortality rates compared with seizure inducer groups. Antioxidant potentials were measured by superoxide dismutase (SOD), catalase (CAT), thiobarbituric acid reactive substances (TBARS), and reduced glutathione (GSH) content in whole-brain homogenates. Gamma-aminobutyric acid (GABA) levels significantly increased in leaves and stem-treated groups, suggesting that MP leaves and stems have potent antioxidant properties that can attenuate convulsions by modulating the GABAergic system and antioxidant activities." @default.
- W4384343602 created "2023-07-15" @default.
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- W4384343602 creator A5030831560 @default.
- W4384343602 creator A5049912845 @default.
- W4384343602 creator A5054307140 @default.
- W4384343602 date "2023-07-01" @default.
- W4384343602 modified "2023-10-05" @default.
- W4384343602 title "GABA content and an antioxidant profile positively correlated with the anticonvulsive activity of Microcos paniculata in acute seizure mice" @default.
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- W4384343602 doi "https://doi.org/10.1016/j.heliyon.2023.e18295" @default.
- W4384343602 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37539232" @default.