Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384343623> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W4384343623 endingPage "104761" @default.
- W4384343623 startingPage "104761" @default.
- W4384343623 abstract "There has been a profusion of trials for SARS CoV2 drugs. A review dating from May 2020 listed 115 medicines, most of which previously existed, having been investigated since the onset of the pandemic. Over an exceedingly short lapse of time, the perspective of the arrival of a new antiviral treatment specifically targeting COVID-19 appeared highly improbable. Three years later, only one treatment is recommended in France: the nirmatrelvir + ritonavir combination. While remdesivir remains available, it is only proposed when this combination is officially contraindicated. Three monoclonal antibodies, taken alone or in association, are currently available in France:: tixagevimab/cilgavimab, casirivimab/imdevimab and sotrovimab. While all three of them have received European market authorization for patients presenting with an increased risk of evolution toward a severe form of COVID-19, and while early access is possible, they are no longer recommended, the reason being a loss or alteration of activity on variants carrying a Spike protein mutation. RoActemra is a humanized monoclonal antibody that blocks the action of interleukin 6 receptors; it is exclusively reserved for adult patients receiving systemic corticotherapy and necessitating oxygen supplementation, while patients under invasive mechanical ventilation are excluded. All in all, since the onset of the pandemic dozens of products have been subjected to tests or trials; three years later, only a highly limited number of candidates remain, and definitive assessment has yet to be achieved." @default.
- W4384343623 created "2023-07-15" @default.
- W4384343623 creator A5019799709 @default.
- W4384343623 date "2023-10-01" @default.
- W4384343623 modified "2023-10-16" @default.
- W4384343623 title "Medical treatment for Covid-19 - three years later" @default.
- W4384343623 cites W3031433295 @default.
- W4384343623 cites W3092854082 @default.
- W4384343623 cites W3107934366 @default.
- W4384343623 cites W3202574112 @default.
- W4384343623 cites W4226236384 @default.
- W4384343623 cites W4293198902 @default.
- W4384343623 cites W4296803319 @default.
- W4384343623 cites W4319812243 @default.
- W4384343623 cites W4324332959 @default.
- W4384343623 cites W4327684954 @default.
- W4384343623 cites W4327943831 @default.
- W4384343623 cites W4378801663 @default.
- W4384343623 cites W4380291084 @default.
- W4384343623 doi "https://doi.org/10.1016/j.idnow.2023.104761" @default.
- W4384343623 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37454763" @default.
- W4384343623 hasPublicationYear "2023" @default.
- W4384343623 type Work @default.
- W4384343623 citedByCount "0" @default.
- W4384343623 crossrefType "journal-article" @default.
- W4384343623 hasAuthorship W4384343623A5019799709 @default.
- W4384343623 hasBestOaLocation W43843436231 @default.
- W4384343623 hasConcept C108759981 @default.
- W4384343623 hasConcept C116675565 @default.
- W4384343623 hasConcept C126322002 @default.
- W4384343623 hasConcept C142462285 @default.
- W4384343623 hasConcept C159047783 @default.
- W4384343623 hasConcept C159654299 @default.
- W4384343623 hasConcept C163864487 @default.
- W4384343623 hasConcept C177713679 @default.
- W4384343623 hasConcept C187212893 @default.
- W4384343623 hasConcept C203014093 @default.
- W4384343623 hasConcept C2522874641 @default.
- W4384343623 hasConcept C2775832928 @default.
- W4384343623 hasConcept C2779134260 @default.
- W4384343623 hasConcept C2779298103 @default.
- W4384343623 hasConcept C2993143319 @default.
- W4384343623 hasConcept C3006700255 @default.
- W4384343623 hasConcept C3007834351 @default.
- W4384343623 hasConcept C3008058167 @default.
- W4384343623 hasConcept C38652104 @default.
- W4384343623 hasConcept C41008148 @default.
- W4384343623 hasConcept C524204448 @default.
- W4384343623 hasConcept C535046627 @default.
- W4384343623 hasConcept C542903549 @default.
- W4384343623 hasConcept C71924100 @default.
- W4384343623 hasConcept C89623803 @default.
- W4384343623 hasConceptScore W4384343623C108759981 @default.
- W4384343623 hasConceptScore W4384343623C116675565 @default.
- W4384343623 hasConceptScore W4384343623C126322002 @default.
- W4384343623 hasConceptScore W4384343623C142462285 @default.
- W4384343623 hasConceptScore W4384343623C159047783 @default.
- W4384343623 hasConceptScore W4384343623C159654299 @default.
- W4384343623 hasConceptScore W4384343623C163864487 @default.
- W4384343623 hasConceptScore W4384343623C177713679 @default.
- W4384343623 hasConceptScore W4384343623C187212893 @default.
- W4384343623 hasConceptScore W4384343623C203014093 @default.
- W4384343623 hasConceptScore W4384343623C2522874641 @default.
- W4384343623 hasConceptScore W4384343623C2775832928 @default.
- W4384343623 hasConceptScore W4384343623C2779134260 @default.
- W4384343623 hasConceptScore W4384343623C2779298103 @default.
- W4384343623 hasConceptScore W4384343623C2993143319 @default.
- W4384343623 hasConceptScore W4384343623C3006700255 @default.
- W4384343623 hasConceptScore W4384343623C3007834351 @default.
- W4384343623 hasConceptScore W4384343623C3008058167 @default.
- W4384343623 hasConceptScore W4384343623C38652104 @default.
- W4384343623 hasConceptScore W4384343623C41008148 @default.
- W4384343623 hasConceptScore W4384343623C524204448 @default.
- W4384343623 hasConceptScore W4384343623C535046627 @default.
- W4384343623 hasConceptScore W4384343623C542903549 @default.
- W4384343623 hasConceptScore W4384343623C71924100 @default.
- W4384343623 hasConceptScore W4384343623C89623803 @default.
- W4384343623 hasIssue "7" @default.
- W4384343623 hasLocation W43843436231 @default.
- W4384343623 hasLocation W43843436232 @default.
- W4384343623 hasOpenAccess W4384343623 @default.
- W4384343623 hasPrimaryLocation W43843436231 @default.
- W4384343623 hasRelatedWork W3017171836 @default.
- W4384343623 hasRelatedWork W3025176011 @default.
- W4384343623 hasRelatedWork W3027835066 @default.
- W4384343623 hasRelatedWork W3032320397 @default.
- W4384343623 hasRelatedWork W3033635008 @default.
- W4384343623 hasRelatedWork W3152606407 @default.
- W4384343623 hasRelatedWork W4280491013 @default.
- W4384343623 hasRelatedWork W4308017287 @default.
- W4384343623 hasRelatedWork W3107152225 @default.
- W4384343623 hasRelatedWork W3183300108 @default.
- W4384343623 hasVolume "53" @default.
- W4384343623 isParatext "false" @default.
- W4384343623 isRetracted "false" @default.
- W4384343623 workType "article" @default.