FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384401124> ?p ?o ?g. }

• W4384401124 endingPage "0" @default.
• W4384401124 startingPage "0" @default.
• W4384401124 abstract "Tocilizumab, a humanized IL-6R monoclonal antibody, has been used in autoimmune diseases closely related to humoral immunity. This report aims to evaluate the efficacy and safety in patients with anti-acetylcholine receptor-positive (AChR+) generalized myasthenia gravis (gMG). We performed a prospective, open-label, single-arm study in patients with gMG in a 48-week follow-up. All patients were AChR+ and were given tocilizumab by intravenous infusion at a dose of 8 mg/kg at intervals of 4 weeks. The primary endpoint was mean change from baseline in quantitative MG (QMG) score at week 12. The secondary endpoints were mean changes from baseline in MG activities of daily living (MG-ADL) score, AChR-ab titers, and the dosage of oral prednisone at week 12. At week 48, QMG, MG-ADL, and the use of prednisone were also evaluated. Fourteen gMG patients were enrolled and all of them completed the study. Tocilizumab treatment started 8 (4-192) months after the onset of gMG. During tocilizumab treatment, the QMG score was significantly decreased from 15.5 (interqualile range, 9-26) at baseline to 4 (0-9) at week 12 (<i>p</i> < 0.001). The change of ADL was decreased from 14.5(11-19) at baseline to 4 (0-19) at week 12 (<i>p</i> < 0.001) and the change of AChR-ab titers from 15 (7.5-19) at baseline to 6.8 (11.6-4.3) at week 12 (<i>p</i> < 0.001). The dosage of prednisone decreased from baseline 60 (20-65) mg/d to 30 (30-50) mg/d at week 12 (<i>p < </i>0.001). By the end of the study, the QMG score was 2 (0-7) and MG-ADL score was 1.5 (0-6). 12 (85.7%) patients achieved minimal manifestations. 4 (28.6%) patients were able to discontinue prednisone. No patients experienced exacerbation at the end of the study. No serious adverse events were observed during follow-up. Tocilizumab treatment was associated with a good clinical response and safety over a 48-week observation period, as evidenced by significant improvements in QMG and MG-ADL." @default.
• W4384401124 created "2023-07-16" @default.
• W4384401124 creator A5012447265 @default.
• W4384401124 creator A5055511404 @default.
• W4384401124 creator A5059761276 @default.
• W4384401124 creator A5062014454 @default.
• W4384401124 creator A5072357964 @default.
• W4384401124 creator A5084148006 @default.
• W4384401124 creator A5089966579 @default.
• W4384401124 date "2023-01-01" @default.
• W4384401124 modified "2023-09-23" @default.
• W4384401124 title "Responsiveness to Tocilizumab in Anti-Acetylcholine Receptor-Positive Generalized Myasthenia Gravis" @default.
• W4384401124 cites W1980447112 @default.
• W4384401124 cites W2051716980 @default.
• W4384401124 cites W2067384298 @default.
• W4384401124 cites W2119118275 @default.
• W4384401124 cites W2139812034 @default.
• W4384401124 cites W2239297208 @default.
• W4384401124 cites W2595610815 @default.
• W4384401124 cites W2736536338 @default.
• W4384401124 cites W2774941197 @default.
• W4384401124 cites W2789644345 @default.
• W4384401124 cites W2797016914 @default.
• W4384401124 cites W2919659424 @default.
• W4384401124 cites W3019956952 @default.
• W4384401124 cites W3023124841 @default.
• W4384401124 cites W3046501287 @default.
• W4384401124 cites W3093749281 @default.
• W4384401124 cites W3094785429 @default.
• W4384401124 cites W3177475622 @default.
• W4384401124 cites W3184195576 @default.
• W4384401124 cites W4205716426 @default.
• W4384401124 cites W4225937918 @default.
• W4384401124 cites W4296329597 @default.
• W4384401124 doi "https://doi.org/10.14336/ad.2023.0528" @default.
• W4384401124 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37450932" @default.
• W4384401124 hasPublicationYear "2023" @default.
• W4384401124 type Work @default.
• W4384401124 citedByCount "0" @default.
• W4384401124 crossrefType "journal-article" @default.
• W4384401124 hasAuthorship W4384401124A5012447265 @default.
• W4384401124 hasAuthorship W4384401124A5055511404 @default.
• W4384401124 hasAuthorship W4384401124A5059761276 @default.
• W4384401124 hasAuthorship W4384401124A5062014454 @default.
• W4384401124 hasAuthorship W4384401124A5072357964 @default.
• W4384401124 hasAuthorship W4384401124A5084148006 @default.
• W4384401124 hasAuthorship W4384401124A5089966579 @default.
• W4384401124 hasBestOaLocation W43844011241 @default.
• W4384401124 hasConcept C126322002 @default.
• W4384401124 hasConcept C159654299 @default.
• W4384401124 hasConcept C168563851 @default.
• W4384401124 hasConcept C203014093 @default.
• W4384401124 hasConcept C203092338 @default.
• W4384401124 hasConcept C2777178219 @default.
• W4384401124 hasConcept C2777575956 @default.
• W4384401124 hasConcept C2778105408 @default.
• W4384401124 hasConcept C2778720950 @default.
• W4384401124 hasConcept C2779384505 @default.
• W4384401124 hasConcept C32611913 @default.
• W4384401124 hasConcept C71924100 @default.
• W4384401124 hasConcept C90924648 @default.
• W4384401124 hasConceptScore W4384401124C126322002 @default.
• W4384401124 hasConceptScore W4384401124C159654299 @default.
• W4384401124 hasConceptScore W4384401124C168563851 @default.
• W4384401124 hasConceptScore W4384401124C203014093 @default.
• W4384401124 hasConceptScore W4384401124C203092338 @default.
• W4384401124 hasConceptScore W4384401124C2777178219 @default.
• W4384401124 hasConceptScore W4384401124C2777575956 @default.
• W4384401124 hasConceptScore W4384401124C2778105408 @default.
• W4384401124 hasConceptScore W4384401124C2778720950 @default.
• W4384401124 hasConceptScore W4384401124C2779384505 @default.
• W4384401124 hasConceptScore W4384401124C32611913 @default.
• W4384401124 hasConceptScore W4384401124C71924100 @default.
• W4384401124 hasConceptScore W4384401124C90924648 @default.
• W4384401124 hasLocation W43844011241 @default.
• W4384401124 hasLocation W43844011242 @default.
• W4384401124 hasOpenAccess W4384401124 @default.
• W4384401124 hasPrimaryLocation W43844011241 @default.
• W4384401124 hasRelatedWork W1511775759 @default.
• W4384401124 hasRelatedWork W2042344642 @default.
• W4384401124 hasRelatedWork W2079253050 @default.
• W4384401124 hasRelatedWork W2098959715 @default.
• W4384401124 hasRelatedWork W2133822197 @default.
• W4384401124 hasRelatedWork W2324954285 @default.
• W4384401124 hasRelatedWork W2370818147 @default.
• W4384401124 hasRelatedWork W2407039491 @default.
• W4384401124 hasRelatedWork W2947522909 @default.
• W4384401124 hasRelatedWork W3048106980 @default.
• W4384401124 isParatext "false" @default.
• W4384401124 isRetracted "false" @default.
• W4384401124 workType "article" @default.