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• W4384401263 endingPage "591" @default.
• W4384401263 startingPage "583" @default.
• W4384401263 abstract "Integration of molecular characterization of lymphomas in clinical diagnostics may improve subclassification and risk-stratification, and we implemented a next generation sequencing (NGS) analysis as part of routine diagnostic work-up of all mature B-cell non-Hodgkin's lymphoma (B-NHL). Here, we present data of mutational profiles with potential complementary diagnostic, prognostic, and predictive value detected in our consecutive non-selected cohort of B-NHL patients.NGS results from 298 patients with both newly diagnosed and relapsed/refractory disease were included as a single center study. NGS was performed as routine analysis together with standard diagnostic work-up using a custom-made amplicon PCR-based multiplex NGS panel covering all coding exons and consensus splice sites in 59 genes.Mutations were detected in 94% of the 298 samples. Most lymphomas could be classified definitively, but 24 cases were classified as small B-cell lymphomas without defining characteristics. Of these, 50% (12/24 cases) could retrospectively be assigned a likely diagnostic subtype according to mutational findings.Implementation of a 59 gene exome sequencing panel added diagnostic value to 50% of unclassified cases and provided in 94% of the cases possible biomarkers for disease monitoring as well as potential diagnostic, prognostic, and predictive markers for future studies." @default.
• W4384401263 created "2023-07-16" @default.
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• W4384401263 date "2023-07-14" @default.
• W4384401263 modified "2023-10-17" @default.
• W4384401263 title "Next generation sequencing in routine diagnostics of mature <scp>non‐Hodgkin</scp>'s B‐cell lymphomas" @default.
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• W4384401263 doi "https://doi.org/10.1111/ejh.14048" @default.
• W4384401263 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37452559" @default.
• W4384401263 hasPublicationYear "2023" @default.
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