Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384404764> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W4384404764 endingPage "163" @default.
- W4384404764 startingPage "152" @default.
- W4384404764 abstract "The RAS/RAF and PI3K/AKT pathways play a crucial regulatory role and oncogenic mutation of key proteins in these pathways leads to cancer metastasis and chemoresistance. Melanoma is triggered by NRAS and BRAF V600E mutation which causes constitutive activation of the PI3K kinase and BRAF kinase respectively, further leading to oncogenic activation of the AKT kinase and mitogen-activated protein kinase (MAPK). Core regulatory network behind MAPK and AKT cascades interconnect and form feedback loops. This crosstalk between the two pathways plays a vital role in melanoma kinase inhibitor resistance. Nuciferine is found in the plants Nelumbo Nucifera and Nymphaea Caerulea. Nuciferine is the main aporphine alkaloid produced in Nelumbo nucifera. Nuciferine have the best efficiency to remove oxygen free radicals and hydroxyl free radicals. Nuciferine have potent ROS scavenging activity. Nuciferine provokes anti-inflammation, anti-psychotic drug, anti-cancer treatment, and anti-obesity diseases. This in silico analysis results reinforces nuciferine has an effective kinase inhibitor with a potential advantage of evading resistance in melanoma by dual targeting. The residues of the substrate binding pockets were identified using literature search. Molecular docking studies was carried out using AutoDock. Docking studies indicated nuciferine and vemurafenib (reference standard) showed better binding affinity for kinase pockets of Braf V600E, MEK, ERK, PI3K, AKT, mTOR and c-KIT. -7.00Kcal/mol is considered as the cut-off energy for inhibition analysis. Hydrophobic interactions were computed using Biovia. Biovia was used for the graphical representation of protein ligand binding." @default.
- W4384404764 created "2023-07-16" @default.
- W4384404764 creator A5044314781 @default.
- W4384404764 creator A5056304824 @default.
- W4384404764 creator A5092172606 @default.
- W4384404764 date "2023-06-30" @default.
- W4384404764 modified "2023-10-18" @default.
- W4384404764 title "In silico kinase inhibition profiling of BRAF and AKT Signaling in Melanoma Cells with Nuciferine" @default.
- W4384404764 doi "https://doi.org/10.31254/phyto.2023.12303" @default.
- W4384404764 hasPublicationYear "2023" @default.
- W4384404764 type Work @default.
- W4384404764 citedByCount "0" @default.
- W4384404764 crossrefType "journal-article" @default.
- W4384404764 hasAuthorship W4384404764A5044314781 @default.
- W4384404764 hasAuthorship W4384404764A5056304824 @default.
- W4384404764 hasAuthorship W4384404764A5092172606 @default.
- W4384404764 hasBestOaLocation W43844047641 @default.
- W4384404764 hasConcept C159110408 @default.
- W4384404764 hasConcept C184235292 @default.
- W4384404764 hasConcept C185592680 @default.
- W4384404764 hasConcept C2776131300 @default.
- W4384404764 hasConcept C2777658100 @default.
- W4384404764 hasConcept C2781249067 @default.
- W4384404764 hasConcept C2994587330 @default.
- W4384404764 hasConcept C41685203 @default.
- W4384404764 hasConcept C502942594 @default.
- W4384404764 hasConcept C55493867 @default.
- W4384404764 hasConcept C57074206 @default.
- W4384404764 hasConcept C62478195 @default.
- W4384404764 hasConcept C71924100 @default.
- W4384404764 hasConcept C75217442 @default.
- W4384404764 hasConcept C86554907 @default.
- W4384404764 hasConcept C86803240 @default.
- W4384404764 hasConcept C90934575 @default.
- W4384404764 hasConcept C97029542 @default.
- W4384404764 hasConcept C98274493 @default.
- W4384404764 hasConcept C99405784 @default.
- W4384404764 hasConceptScore W4384404764C159110408 @default.
- W4384404764 hasConceptScore W4384404764C184235292 @default.
- W4384404764 hasConceptScore W4384404764C185592680 @default.
- W4384404764 hasConceptScore W4384404764C2776131300 @default.
- W4384404764 hasConceptScore W4384404764C2777658100 @default.
- W4384404764 hasConceptScore W4384404764C2781249067 @default.
- W4384404764 hasConceptScore W4384404764C2994587330 @default.
- W4384404764 hasConceptScore W4384404764C41685203 @default.
- W4384404764 hasConceptScore W4384404764C502942594 @default.
- W4384404764 hasConceptScore W4384404764C55493867 @default.
- W4384404764 hasConceptScore W4384404764C57074206 @default.
- W4384404764 hasConceptScore W4384404764C62478195 @default.
- W4384404764 hasConceptScore W4384404764C71924100 @default.
- W4384404764 hasConceptScore W4384404764C75217442 @default.
- W4384404764 hasConceptScore W4384404764C86554907 @default.
- W4384404764 hasConceptScore W4384404764C86803240 @default.
- W4384404764 hasConceptScore W4384404764C90934575 @default.
- W4384404764 hasConceptScore W4384404764C97029542 @default.
- W4384404764 hasConceptScore W4384404764C98274493 @default.
- W4384404764 hasConceptScore W4384404764C99405784 @default.
- W4384404764 hasIssue "3" @default.
- W4384404764 hasLocation W43844047641 @default.
- W4384404764 hasOpenAccess W4384404764 @default.
- W4384404764 hasPrimaryLocation W43844047641 @default.
- W4384404764 hasRelatedWork W1860343172 @default.
- W4384404764 hasRelatedWork W2011123717 @default.
- W4384404764 hasRelatedWork W2109132296 @default.
- W4384404764 hasRelatedWork W2216439242 @default.
- W4384404764 hasRelatedWork W2261929084 @default.
- W4384404764 hasRelatedWork W2413143136 @default.
- W4384404764 hasRelatedWork W2478221824 @default.
- W4384404764 hasRelatedWork W2890752806 @default.
- W4384404764 hasRelatedWork W2901178839 @default.
- W4384404764 hasRelatedWork W4362524736 @default.
- W4384404764 hasVolume "12" @default.
- W4384404764 isParatext "false" @default.
- W4384404764 isRetracted "false" @default.
- W4384404764 workType "article" @default.