Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384404766> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W4384404766 endingPage "151" @default.
- W4384404766 startingPage "143" @default.
- W4384404766 abstract "Background: The high morbidity and mortality associated with microbial infections and the ineffectiveness of conventional antibiotics due to inappropriate use and resistance warrant alternative stratagems. Aim: We investigated the antimicrobial, cytotoxicity, and qualitative phytochemical composition of the aqueous and methanolic leaf extracts of Physalis peruviana L. (Solanaceae) based on its ethnomedicinal information. Methods: The antimicrobial activity of the extracts was investigated using the disk diffusion technique. The brine shrimp lethality assay method was used to determine the cytotoxicity of the study extracts on brine shrimp nauplii. Qualitative phytochemistry of the study extracts was performed using standard procedures. Results: The two extracts did not possess antimicrobial activity against P. aeruginosa and were either inactive or slightly inactive against the other microbes at concentrations of ≤ 50 µg/ml. Notably, the aqueous extract exhibited high to very high activities against E. coli and S. aureus and very high to remarkable activities against B. cereus. The methanolic extract showed remarkable activity at concentrations of ≥200 µg/ml against E. coli, moderate to very high against S. aureus, high to very high against B. cereus, and moderate to high against C. albicans. The aqueous extract's minimum inhibitory concentrations (MICs) were 50 μg/ml (E. coli and B. cereus), 100 μg/ml (S. aureus), and 200 μg/ml (C. albicans). The minimum bactericidal concentration concentrations (MBCs) of the aqueous extract were 100 μg/ml (E. coli and B. cereus), 200 μg/ml (S. aureus), while the minimum fungicidal concentration (MFC) for C. albicans was 400 μg/ml. The MICs of the methanolic extract were 25 μg/ml for E. coli, S. aureus, and B. cereus and 100 μg/ml for C. albicans, and the MBCs were 100 μg/ml for E. coli, S. aureus, and B. cereus, and the MFC for C. albicans was 200 μg/ml. The aqueous was non-toxic, while the methanolic extract was slightly toxic to brine shrimp nauplii, indicating their relative safety. Various phytochemicals were detected in the study extracts, depicting broad pharmacologic activity, including antimicrobial activity. Conclusion: The aqueous and methanolic leaf extracts of P. peruviana may serve as a source of efficacious and safe novel antimicrobial agents upon further evaluation." @default.
- W4384404766 created "2023-07-16" @default.
- W4384404766 creator A5031704261 @default.
- W4384404766 creator A5052613002 @default.
- W4384404766 creator A5058911583 @default.
- W4384404766 creator A5068400599 @default.
- W4384404766 date "2023-06-30" @default.
- W4384404766 modified "2023-09-26" @default.
- W4384404766 title "Antimicrobial activity, cytotoxicity, and qualitative phytochemical composition of aqueous and methanolic leaf extracts of Physalis peruviana L. (Solanaceae)" @default.
- W4384404766 doi "https://doi.org/10.31254/phyto.2023.12302" @default.
- W4384404766 hasPublicationYear "2023" @default.
- W4384404766 type Work @default.
- W4384404766 citedByCount "0" @default.
- W4384404766 crossrefType "journal-article" @default.
- W4384404766 hasAuthorship W4384404766A5031704261 @default.
- W4384404766 hasAuthorship W4384404766A5052613002 @default.
- W4384404766 hasAuthorship W4384404766A5058911583 @default.
- W4384404766 hasAuthorship W4384404766A5068400599 @default.
- W4384404766 hasBestOaLocation W43844047661 @default.
- W4384404766 hasConcept C176947019 @default.
- W4384404766 hasConcept C185592680 @default.
- W4384404766 hasConcept C195475562 @default.
- W4384404766 hasConcept C2775873308 @default.
- W4384404766 hasConcept C2776984453 @default.
- W4384404766 hasConcept C2777118263 @default.
- W4384404766 hasConcept C2780373777 @default.
- W4384404766 hasConcept C2780917455 @default.
- W4384404766 hasConcept C2780950330 @default.
- W4384404766 hasConcept C31903555 @default.
- W4384404766 hasConcept C4937899 @default.
- W4384404766 hasConcept C523546767 @default.
- W4384404766 hasConcept C54355233 @default.
- W4384404766 hasConcept C556039675 @default.
- W4384404766 hasConcept C59822182 @default.
- W4384404766 hasConcept C71924100 @default.
- W4384404766 hasConcept C86803240 @default.
- W4384404766 hasConcept C89423630 @default.
- W4384404766 hasConceptScore W4384404766C176947019 @default.
- W4384404766 hasConceptScore W4384404766C185592680 @default.
- W4384404766 hasConceptScore W4384404766C195475562 @default.
- W4384404766 hasConceptScore W4384404766C2775873308 @default.
- W4384404766 hasConceptScore W4384404766C2776984453 @default.
- W4384404766 hasConceptScore W4384404766C2777118263 @default.
- W4384404766 hasConceptScore W4384404766C2780373777 @default.
- W4384404766 hasConceptScore W4384404766C2780917455 @default.
- W4384404766 hasConceptScore W4384404766C2780950330 @default.
- W4384404766 hasConceptScore W4384404766C31903555 @default.
- W4384404766 hasConceptScore W4384404766C4937899 @default.
- W4384404766 hasConceptScore W4384404766C523546767 @default.
- W4384404766 hasConceptScore W4384404766C54355233 @default.
- W4384404766 hasConceptScore W4384404766C556039675 @default.
- W4384404766 hasConceptScore W4384404766C59822182 @default.
- W4384404766 hasConceptScore W4384404766C71924100 @default.
- W4384404766 hasConceptScore W4384404766C86803240 @default.
- W4384404766 hasConceptScore W4384404766C89423630 @default.
- W4384404766 hasIssue "3" @default.
- W4384404766 hasLocation W43844047661 @default.
- W4384404766 hasOpenAccess W4384404766 @default.
- W4384404766 hasPrimaryLocation W43844047661 @default.
- W4384404766 hasRelatedWork W138401483 @default.
- W4384404766 hasRelatedWork W1481676406 @default.
- W4384404766 hasRelatedWork W2266443942 @default.
- W4384404766 hasRelatedWork W2554482650 @default.
- W4384404766 hasRelatedWork W2753184995 @default.
- W4384404766 hasRelatedWork W2951817240 @default.
- W4384404766 hasRelatedWork W2980927461 @default.
- W4384404766 hasRelatedWork W4280557691 @default.
- W4384404766 hasRelatedWork W4319738869 @default.
- W4384404766 hasRelatedWork W2186889101 @default.
- W4384404766 hasVolume "12" @default.
- W4384404766 isParatext "false" @default.
- W4384404766 isRetracted "false" @default.
- W4384404766 workType "article" @default.