FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384404836> ?p ?o ?g. }

• W4384404836 endingPage "109348" @default.
• W4384404836 startingPage "109348" @default.
• W4384404836 abstract "Introduction Infantile epileptic spasms syndrome (IESS) is characterized by epileptic spasms, regardless of hypsarrhythmia on electroencephalogram or neurodevelopmental delay. In Japan, pyridoxal 5′-phosphate (PLP) is often used as the first-line treatment for IESS because it is effective in a certain number of patients. Although several studies have reported serious adverse events following PLP treatment, no study has investigated the risk factors for such occurrences. Objective To investigate adverse events associated with PLP therapy for the treatment of IESS and to identify the associated risk factors. Materials and methods We retrospectively evaluated adverse events in 59 patients with IESS at Tottori University Hospital between January 1995 and September 2022. We subsequently collected and analyzed their clinical data and analyzed the risk factors associated with each adverse event. The cutoff values and relative risk (RR) were analyzed for items with significant associations with adverse events. Results Twenty-seven (51.9%) participants experienced adverse events, including vomiting in 16 participants (59.3%), elevated liver enzyme levels in 15 participants (55.6%), and rhabdomyolysis in two participants (3.4%). No significant differences were observed between the non-adverse events group and the overall adverse events group, as well as between the non-adverse events group and the vomiting group, in terms of the factors examined. However, when comparing the non-adverse events group with the group with elevated liver enzyme levels, age at PLP treatment showed a negative correlation, whereas PLP dose showed a positive correlation with elevated liver enzyme levels. The cutoff dose was 40 mg/kg/day (73.3% sensitivity and 60.7% specificity), and the cutoff age was 9 months (100% sensitivity and 40.0% specificity). RRs of doses ≥40 mg/kg/day and age <9 months were 2.6 and 3.6, respectively. Conclusions Adverse events of PLP therapy, including vomiting, elevated liver enzymes, and rhabdomyolysis, were observed in approximately half of the participants. Age under 9 months and a dose ≥40 mg/kg/day were identified as risk factors for elevation of liver enzymes on PLP treatment in infants with IESS, with rhabdomyolysis can occur in the younger or higher dose cases." @default.
• W4384404836 created "2023-07-16" @default.
• W4384404836 creator A5005224980 @default.
• W4384404836 creator A5015391663 @default.
• W4384404836 creator A5016211338 @default.
• W4384404836 creator A5035993175 @default.
• W4384404836 creator A5067326699 @default.
• W4384404836 creator A5080187738 @default.
• W4384404836 creator A5084041690 @default.
• W4384404836 date "2023-08-01" @default.
• W4384404836 modified "2023-09-23" @default.
• W4384404836 title "Identifying risk factors for adverse events of pyridoxal phosphate in infantile epileptic spasms syndrome" @default.
• W4384404836 cites W1940036272 @default.
• W4384404836 cites W1975631283 @default.
• W4384404836 cites W1978567215 @default.
• W4384404836 cites W2033903019 @default.
• W4384404836 cites W2040934932 @default.
• W4384404836 cites W2066430647 @default.
• W4384404836 cites W2074615203 @default.
• W4384404836 cites W2112669742 @default.
• W4384404836 cites W2155380051 @default.
• W4384404836 cites W2165788910 @default.
• W4384404836 cites W2592509339 @default.
• W4384404836 cites W2736086209 @default.
• W4384404836 cites W2802755841 @default.
• W4384404836 cites W2995548294 @default.
• W4384404836 cites W3128743916 @default.
• W4384404836 cites W3135765418 @default.
• W4384404836 cites W4206022775 @default.
• W4384404836 cites W4225383465 @default.
• W4384404836 doi "https://doi.org/10.1016/j.yebeh.2023.109348" @default.
• W4384404836 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37459718" @default.
• W4384404836 hasPublicationYear "2023" @default.
• W4384404836 type Work @default.
• W4384404836 citedByCount "0" @default.
• W4384404836 crossrefType "journal-article" @default.
• W4384404836 hasAuthorship W4384404836A5005224980 @default.
• W4384404836 hasAuthorship W4384404836A5015391663 @default.
• W4384404836 hasAuthorship W4384404836A5016211338 @default.
• W4384404836 hasAuthorship W4384404836A5035993175 @default.
• W4384404836 hasAuthorship W4384404836A5067326699 @default.
• W4384404836 hasAuthorship W4384404836A5080187738 @default.
• W4384404836 hasAuthorship W4384404836A5084041690 @default.
• W4384404836 hasConcept C118552586 @default.
• W4384404836 hasConcept C126322002 @default.
• W4384404836 hasConcept C187212893 @default.
• W4384404836 hasConcept C197934379 @default.
• W4384404836 hasConcept C2778186239 @default.
• W4384404836 hasConcept C2779888125 @default.
• W4384404836 hasConcept C2780852908 @default.
• W4384404836 hasConcept C44249647 @default.
• W4384404836 hasConcept C71924100 @default.
• W4384404836 hasConcept C82789193 @default.
• W4384404836 hasConceptScore W4384404836C118552586 @default.
• W4384404836 hasConceptScore W4384404836C126322002 @default.
• W4384404836 hasConceptScore W4384404836C187212893 @default.
• W4384404836 hasConceptScore W4384404836C197934379 @default.
• W4384404836 hasConceptScore W4384404836C2778186239 @default.
• W4384404836 hasConceptScore W4384404836C2779888125 @default.
• W4384404836 hasConceptScore W4384404836C2780852908 @default.
• W4384404836 hasConceptScore W4384404836C44249647 @default.
• W4384404836 hasConceptScore W4384404836C71924100 @default.
• W4384404836 hasConceptScore W4384404836C82789193 @default.
• W4384404836 hasLocation W43844048361 @default.
• W4384404836 hasLocation W43844048362 @default.
• W4384404836 hasOpenAccess W4384404836 @default.
• W4384404836 hasPrimaryLocation W43844048361 @default.
• W4384404836 hasRelatedWork W1599451020 @default.
• W4384404836 hasRelatedWork W1723356646 @default.
• W4384404836 hasRelatedWork W2022544233 @default.
• W4384404836 hasRelatedWork W2096612642 @default.
• W4384404836 hasRelatedWork W2199474016 @default.
• W4384404836 hasRelatedWork W2513347725 @default.
• W4384404836 hasRelatedWork W2893772422 @default.
• W4384404836 hasRelatedWork W3124002180 @default.
• W4384404836 hasRelatedWork W4255361753 @default.
• W4384404836 hasRelatedWork W4322722437 @default.
• W4384404836 hasVolume "145" @default.
• W4384404836 isParatext "false" @default.
• W4384404836 isRetracted "false" @default.
• W4384404836 workType "article" @default.