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- W4384405690 abstract "Glioblastoma multiforme (GBM), the most aggressive primary malignant brain tumor, is resistant to conventional radiotherapies and chemotherapies, including temozolomide (TMZ). Overcoming GBM resistance to the chemotherapeutic agent TMZ poses an important therapeutic problem. This study established an association between the long noncoding RNA TP73-AS1 and TMZ sensitivity regulation in human GBM cells (U87MG). Transcriptomic analysis revealed that TP73-AS1 expression was reduced in TMZ-resistant U87MGRT100 cells compared to that in parental U87MG cells. Additionally, TP73-AS1 knockdown in parental U87MG cells decreased their sensitivity to TMZ. Overall, these findings suggest that TP73-AS1 functions as a regulator of TMZ sensitivity in GBM cells." @default.
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- W4384405690 date "2023-07-15" @default.
- W4384405690 modified "2023-09-25" @default.
- W4384405690 title "Downregulation of long noncoding RNA <i>TP73-AS1</i> expression confers resistance to temozolomide in human glioblastoma cells" @default.
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- W4384405690 doi "https://doi.org/10.1080/15257770.2023.2234960" @default.
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