Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384405735> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W4384405735 endingPage "0112" @default.
- W4384405735 startingPage "jrheum.2023" @default.
- W4384405735 abstract "This posthoc analysis investigated the relationship between paraoxonase-1 (PON1) genotype and activity, and risk of major adverse cardiovascular events (MACE) and malignancies in clinical studies of tofacitinib in patients with rheumatoid arthritis (RA).Data were pooled from 9 phase II/III studies and the associated long-term extension studies (all completed by October 2017). PON1 activities in plasma were measured using paraoxon (paraoxonase activity), dihydrocoumarin (lactonase activity), and phenylacetate (arylesterase activity) as substrates. PON1 Q192R genotype effect on baseline PON1 activity was assessed using linear regression for each study, with fixed-effects metaanalysis across studies. MACE and malignancy risk by time-varying enzyme activity was determined using Cox proportional hazards regression.The analysis included 1969 patients with RA. Compared with the QQ genotype, the RR genotype had a significant positive association with baseline paraoxonase activity and a significant negative association with baseline lactonase and arylesterase activity (all P < 0.001). Time-varying models demonstrated a significant association of increased paraoxonase activity over time with lower risk of MACE (P < 0.001) and malignancies (excluding nonmelanoma skin cancer [NMSC]; P ≤ 0.05), even after controlling for risk factors identified in univariate analysis and RA disease activity. A similar trend was observed for lactonase and arylesterase for MACE.Higher paraoxonase activity over time was associated with significantly reduced risk of future MACE and malignancies (excluding NMSC), but not NMSC, in patients with RA receiving tofacitinib. Further investigation of PON1 as a novel functional lipid biomarker of MACE/malignancy risk in patients with RA is warranted. (ClinicalTrials.gov: NCT01059864, NCT00550446, NCT00687193, NCT00960440, NCT00814307, NCT00856544, NCT00853385, NCT00847613, NCT01039688, NCT00413699, NCT00661661)." @default.
- W4384405735 created "2023-07-16" @default.
- W4384405735 creator A5006954047 @default.
- W4384405735 creator A5016111416 @default.
- W4384405735 creator A5020980740 @default.
- W4384405735 creator A5027269428 @default.
- W4384405735 creator A5040803507 @default.
- W4384405735 creator A5045858447 @default.
- W4384405735 creator A5048310284 @default.
- W4384405735 creator A5053677467 @default.
- W4384405735 date "2023-07-15" @default.
- W4384405735 modified "2023-09-30" @default.
- W4384405735 title "Relationship Between Paraoxonase-1 Genotype and Activity, and Major Adverse Cardiovascular Events and Malignancies in Patients with Rheumatoid Arthritis Receiving Tofacitinib" @default.
- W4384405735 doi "https://doi.org/10.3899/jrheum.2023-0112" @default.
- W4384405735 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37453736" @default.
- W4384405735 hasPublicationYear "2023" @default.
- W4384405735 type Work @default.
- W4384405735 citedByCount "0" @default.
- W4384405735 crossrefType "journal-article" @default.
- W4384405735 hasAuthorship W4384405735A5006954047 @default.
- W4384405735 hasAuthorship W4384405735A5016111416 @default.
- W4384405735 hasAuthorship W4384405735A5020980740 @default.
- W4384405735 hasAuthorship W4384405735A5027269428 @default.
- W4384405735 hasAuthorship W4384405735A5040803507 @default.
- W4384405735 hasAuthorship W4384405735A5045858447 @default.
- W4384405735 hasAuthorship W4384405735A5048310284 @default.
- W4384405735 hasAuthorship W4384405735A5053677467 @default.
- W4384405735 hasBestOaLocation W43844057351 @default.
- W4384405735 hasConcept C104317684 @default.
- W4384405735 hasConcept C126322002 @default.
- W4384405735 hasConcept C135763542 @default.
- W4384405735 hasConcept C143998085 @default.
- W4384405735 hasConcept C2776151105 @default.
- W4384405735 hasConcept C2776509667 @default.
- W4384405735 hasConcept C2776897752 @default.
- W4384405735 hasConcept C2777575956 @default.
- W4384405735 hasConcept C2778886723 @default.
- W4384405735 hasConcept C2780739214 @default.
- W4384405735 hasConcept C2781389560 @default.
- W4384405735 hasConcept C37501387 @default.
- W4384405735 hasConcept C45393284 @default.
- W4384405735 hasConcept C500558357 @default.
- W4384405735 hasConcept C54355233 @default.
- W4384405735 hasConcept C55493867 @default.
- W4384405735 hasConcept C71924100 @default.
- W4384405735 hasConcept C86803240 @default.
- W4384405735 hasConcept C90924648 @default.
- W4384405735 hasConceptScore W4384405735C104317684 @default.
- W4384405735 hasConceptScore W4384405735C126322002 @default.
- W4384405735 hasConceptScore W4384405735C135763542 @default.
- W4384405735 hasConceptScore W4384405735C143998085 @default.
- W4384405735 hasConceptScore W4384405735C2776151105 @default.
- W4384405735 hasConceptScore W4384405735C2776509667 @default.
- W4384405735 hasConceptScore W4384405735C2776897752 @default.
- W4384405735 hasConceptScore W4384405735C2777575956 @default.
- W4384405735 hasConceptScore W4384405735C2778886723 @default.
- W4384405735 hasConceptScore W4384405735C2780739214 @default.
- W4384405735 hasConceptScore W4384405735C2781389560 @default.
- W4384405735 hasConceptScore W4384405735C37501387 @default.
- W4384405735 hasConceptScore W4384405735C45393284 @default.
- W4384405735 hasConceptScore W4384405735C500558357 @default.
- W4384405735 hasConceptScore W4384405735C54355233 @default.
- W4384405735 hasConceptScore W4384405735C55493867 @default.
- W4384405735 hasConceptScore W4384405735C71924100 @default.
- W4384405735 hasConceptScore W4384405735C86803240 @default.
- W4384405735 hasConceptScore W4384405735C90924648 @default.
- W4384405735 hasLocation W43844057351 @default.
- W4384405735 hasLocation W43844057352 @default.
- W4384405735 hasOpenAccess W4384405735 @default.
- W4384405735 hasPrimaryLocation W43844057351 @default.
- W4384405735 hasRelatedWork W2009945655 @default.
- W4384405735 hasRelatedWork W2052174820 @default.
- W4384405735 hasRelatedWork W2075995559 @default.
- W4384405735 hasRelatedWork W2752578853 @default.
- W4384405735 hasRelatedWork W2806425438 @default.
- W4384405735 hasRelatedWork W2883408299 @default.
- W4384405735 hasRelatedWork W3165766744 @default.
- W4384405735 hasRelatedWork W4382652497 @default.
- W4384405735 hasRelatedWork W4384405735 @default.
- W4384405735 hasRelatedWork W66608086 @default.
- W4384405735 isParatext "false" @default.
- W4384405735 isRetracted "false" @default.
- W4384405735 workType "article" @default.