Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384407101> ?p ?o ?g. }
- W4384407101 abstract "Abstract The Notch gene, a highly evolutionarily conserved gene, was discovered approximately 110 years ago and has been found to play a crucial role in the development of multicellular organisms. Notch receptors and their ligands are single-pass transmembrane proteins that typically require cellular interactions and proteolytic processing to facilitate signal transduction. Recently, mounting evidence has shown that aberrant activation of the Notch is correlated with neuropathic pain. The activation of the Notch signaling pathway can cause the activation of neuroglia and the release of pro-inflammatory factors, a key mechanism in the development of neuropathic pain. Moreover, the Notch signaling pathway may contribute to the persistence of neuropathic pain by enhancing synaptic transmission and calcium inward flow. This paper reviews the structure and activation of the Notch signaling pathway, as well as its potential mechanisms of action, to provide novel insights for future treatments of neuropathic pain." @default.
- W4384407101 created "2023-07-16" @default.
- W4384407101 creator A5003409121 @default.
- W4384407101 creator A5006165921 @default.
- W4384407101 creator A5010824256 @default.
- W4384407101 creator A5048346372 @default.
- W4384407101 creator A5054352845 @default.
- W4384407101 creator A5081093007 @default.
- W4384407101 creator A5086664284 @default.
- W4384407101 date "2023-07-15" @default.
- W4384407101 modified "2023-09-25" @default.
- W4384407101 title "Notch signaling pathway: a new target for neuropathic pain therapy" @default.
- W4384407101 cites W1508615665 @default.
- W4384407101 cites W1516426911 @default.
- W4384407101 cites W1671611039 @default.
- W4384407101 cites W1793808483 @default.
- W4384407101 cites W1943662711 @default.
- W4384407101 cites W1964484907 @default.
- W4384407101 cites W1965102171 @default.
- W4384407101 cites W1966997433 @default.
- W4384407101 cites W1971063834 @default.
- W4384407101 cites W1978525834 @default.
- W4384407101 cites W1979220616 @default.
- W4384407101 cites W1981563641 @default.
- W4384407101 cites W1985657116 @default.
- W4384407101 cites W1997801717 @default.
- W4384407101 cites W2009761130 @default.
- W4384407101 cites W2027620926 @default.
- W4384407101 cites W2028916975 @default.
- W4384407101 cites W2029503801 @default.
- W4384407101 cites W2031298329 @default.
- W4384407101 cites W2041677049 @default.
- W4384407101 cites W2047074552 @default.
- W4384407101 cites W2047790141 @default.
- W4384407101 cites W2051385290 @default.
- W4384407101 cites W2055197670 @default.
- W4384407101 cites W2056483677 @default.
- W4384407101 cites W2056688527 @default.
- W4384407101 cites W2063158307 @default.
- W4384407101 cites W2064647534 @default.
- W4384407101 cites W2076474317 @default.
- W4384407101 cites W2077243146 @default.
- W4384407101 cites W2083425643 @default.
- W4384407101 cites W2084376687 @default.
- W4384407101 cites W2095989612 @default.
- W4384407101 cites W2106372072 @default.
- W4384407101 cites W2106450957 @default.
- W4384407101 cites W2109894804 @default.
- W4384407101 cites W2111324887 @default.
- W4384407101 cites W2111631879 @default.
- W4384407101 cites W2121086045 @default.
- W4384407101 cites W2125548273 @default.
- W4384407101 cites W2127298360 @default.
- W4384407101 cites W2133708523 @default.
- W4384407101 cites W2142699862 @default.
- W4384407101 cites W2147298899 @default.
- W4384407101 cites W2162569522 @default.
- W4384407101 cites W2165086211 @default.
- W4384407101 cites W2168393307 @default.
- W4384407101 cites W2170019750 @default.
- W4384407101 cites W2170621724 @default.
- W4384407101 cites W2170692256 @default.
- W4384407101 cites W2185639502 @default.
- W4384407101 cites W2190494517 @default.
- W4384407101 cites W2489528588 @default.
- W4384407101 cites W2552402939 @default.
- W4384407101 cites W2553154860 @default.
- W4384407101 cites W2564783278 @default.
- W4384407101 cites W2615263304 @default.
- W4384407101 cites W2626179193 @default.
- W4384407101 cites W2739832422 @default.
- W4384407101 cites W2744829308 @default.
- W4384407101 cites W2755269699 @default.
- W4384407101 cites W2762329945 @default.
- W4384407101 cites W2765208921 @default.
- W4384407101 cites W2775880141 @default.
- W4384407101 cites W2779829446 @default.
- W4384407101 cites W2782429951 @default.
- W4384407101 cites W2786438865 @default.
- W4384407101 cites W2789682581 @default.
- W4384407101 cites W2789922692 @default.
- W4384407101 cites W2793983403 @default.
- W4384407101 cites W2796022005 @default.
- W4384407101 cites W2802537338 @default.
- W4384407101 cites W2884522219 @default.
- W4384407101 cites W2897440145 @default.
- W4384407101 cites W2906590066 @default.
- W4384407101 cites W2907017802 @default.
- W4384407101 cites W2917093803 @default.
- W4384407101 cites W2921489046 @default.
- W4384407101 cites W2947208469 @default.
- W4384407101 cites W2962786907 @default.
- W4384407101 cites W2974865755 @default.
- W4384407101 cites W2983196198 @default.
- W4384407101 cites W3000434770 @default.
- W4384407101 cites W3004257311 @default.
- W4384407101 cites W3008553231 @default.
- W4384407101 cites W3008705165 @default.
- W4384407101 cites W3015760323 @default.
- W4384407101 cites W3036108906 @default.