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• W4384408090 abstract "Abstract Background For safe and effective holmium-166 ( 166 Ho) liver radioembolization, dosimetry is crucial and requires accurate healthy liver definition. The current clinical standard relies on manual segmentation and registration of a separately acquired contrast enhanced CT (CECT), a prone-to-error and time-consuming task. An alternative is offered by simultaneous imaging of 166 Ho and technetium-99m stannous–phytate accumulating in healthy liver cells ( 166 Ho– 99m Tc dual-isotope protocol). This study compares healthy liver segmentation performed with an automatic method using 99m Tc images derived from a 166 Ho– 99m Tc dual-isotope acquisition to the manual segmentation, focusing on healthy liver dosimetry and corresponding hepatotoxicity. Data from the prospective HEPAR PLuS study were used. Automatic healthy liver segmentation was obtained by thresholding the 99m Tc image (no registration step required). Manual segmentation was performed on CECT and then manually registered to the SPECT/CT and subsequently to the corresponding 166 Ho SPECT to compute absorbed dose in healthy liver. Results Thirty-one patients (66 procedures) were assessed. Manual segmentation and registration took a median of 30 min per patient, while automatic segmentation was instantaneous. Mean ± standard deviation of healthy liver absorbed dose was 18 ± 7 Gy and 20 ± 8 Gy for manual and automatic segmentations, respectively. Mean difference ± coefficient of reproducibility between healthy liver absorbed doses using the automatic versus manual segmentation was 2 ± 6 Gy. No correlation was found between mean absorbed dose in the healthy liver and hepatotoxicity. Conclusions 166 Ho– 99m Tc dual-isotope protocol can automatically segment the healthy liver without hampering the 166 Ho dosimetry assessment. Trial registration : ClinicalTrials.gov, NCT02067988. Registered 20 February 2014. https://clinicaltrials.gov/ct2/show/NCT02067988" @default.
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• W4384408090 date "2023-07-15" @default.
• W4384408090 modified "2023-10-14" @default.
• W4384408090 title "Automatic healthy liver segmentation for holmium-166 radioembolization dosimetry" @default.
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• W4384408090 doi "https://doi.org/10.1186/s13550-023-00996-1" @default.
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