Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384408093> ?p ?o ?g. }
- W4384408093 endingPage "1224" @default.
- W4384408093 startingPage "1212" @default.
- W4384408093 abstract "Immune checkpoint therapies (ICT) can reinvigorate the effector functions of anti-tumour T cells, improving cancer patient outcomes. Anti-tumour T cells are initially formed during their first contact (priming) with tumour antigens by antigen-presenting cells (APCs). Unfortunately, many patients are refractory to ICT because their tumours are considered to be 'cold' tumours-i.e., they do not allow the generation of T cells (so-called 'desert' tumours) or the infiltration of existing anti-tumour T cells (T-cell-excluded tumours). Desert tumours disturb antigen processing and priming of T cells by targeting APCs with suppressive tumour factors derived from their genetic instabilities. In contrast, T-cell-excluded tumours are characterised by blocking effective anti-tumour T lymphocytes infiltrating cancer masses by obstacles, such as fibrosis and tumour-cell-induced immunosuppression. This review delves into critical mechanisms by which cancer cells induce T-cell 'desertification' and 'exclusion' in ICT refractory tumours. Filling the gaps in our knowledge regarding these pro-tumoral mechanisms will aid researchers in developing novel class immunotherapies that aim at restoring T-cell generation with more efficient priming by APCs and leukocyte tumour trafficking. Such developments are expected to unleash the clinical benefit of ICT in refractory patients." @default.
- W4384408093 created "2023-07-16" @default.
- W4384408093 creator A5016681267 @default.
- W4384408093 creator A5031298664 @default.
- W4384408093 creator A5068974417 @default.
- W4384408093 creator A5071573571 @default.
- W4384408093 date "2023-07-15" @default.
- W4384408093 modified "2023-10-16" @default.
- W4384408093 title "Resistance to immune checkpoint therapies by tumour-induced T-cell desertification and exclusion: key mechanisms, prognostication and new therapeutic opportunities" @default.
- W4384408093 cites W1498931318 @default.
- W4384408093 cites W1552742962 @default.
- W4384408093 cites W1973722969 @default.
- W4384408093 cites W1987753922 @default.
- W4384408093 cites W1990403579 @default.
- W4384408093 cites W1997750076 @default.
- W4384408093 cites W2004911979 @default.
- W4384408093 cites W2019214729 @default.
- W4384408093 cites W2021037655 @default.
- W4384408093 cites W2028448128 @default.
- W4384408093 cites W2032639324 @default.
- W4384408093 cites W2039123767 @default.
- W4384408093 cites W2046781420 @default.
- W4384408093 cites W2060070314 @default.
- W4384408093 cites W2060910588 @default.
- W4384408093 cites W2063541870 @default.
- W4384408093 cites W2065813312 @default.
- W4384408093 cites W2068116723 @default.
- W4384408093 cites W2071483270 @default.
- W4384408093 cites W2079018735 @default.
- W4384408093 cites W2087680655 @default.
- W4384408093 cites W2092526035 @default.
- W4384408093 cites W2092586559 @default.
- W4384408093 cites W2094366129 @default.
- W4384408093 cites W2106067112 @default.
- W4384408093 cites W2106973035 @default.
- W4384408093 cites W2109485845 @default.
- W4384408093 cites W2110852884 @default.
- W4384408093 cites W2116850184 @default.
- W4384408093 cites W2117129729 @default.
- W4384408093 cites W2118103791 @default.
- W4384408093 cites W2121820529 @default.
- W4384408093 cites W2128165382 @default.
- W4384408093 cites W2135730659 @default.
- W4384408093 cites W2149244682 @default.
- W4384408093 cites W2161048718 @default.
- W4384408093 cites W2166662937 @default.
- W4384408093 cites W2201379305 @default.
- W4384408093 cites W2201541946 @default.
- W4384408093 cites W2236879811 @default.
- W4384408093 cites W2259408979 @default.
- W4384408093 cites W2276555358 @default.
- W4384408093 cites W2285621780 @default.
- W4384408093 cites W2291366206 @default.
- W4384408093 cites W2295630215 @default.
- W4384408093 cites W2341604280 @default.
- W4384408093 cites W2418503820 @default.
- W4384408093 cites W2437166935 @default.
- W4384408093 cites W2572174216 @default.
- W4384408093 cites W2578528809 @default.
- W4384408093 cites W2579253639 @default.
- W4384408093 cites W2587048937 @default.
- W4384408093 cites W2600428043 @default.
- W4384408093 cites W2604931745 @default.
- W4384408093 cites W2729828302 @default.
- W4384408093 cites W2742763599 @default.
- W4384408093 cites W2745658163 @default.
- W4384408093 cites W2762602728 @default.
- W4384408093 cites W2765417948 @default.
- W4384408093 cites W2766016994 @default.
- W4384408093 cites W2779221466 @default.
- W4384408093 cites W2782007611 @default.
- W4384408093 cites W2782949806 @default.
- W4384408093 cites W2784732900 @default.
- W4384408093 cites W2785803176 @default.
- W4384408093 cites W2789421415 @default.
- W4384408093 cites W2800769338 @default.
- W4384408093 cites W2801211626 @default.
- W4384408093 cites W2801285271 @default.
- W4384408093 cites W2811013844 @default.
- W4384408093 cites W2867818201 @default.
- W4384408093 cites W2883970691 @default.
- W4384408093 cites W2886498337 @default.
- W4384408093 cites W2890875511 @default.
- W4384408093 cites W2897169825 @default.
- W4384408093 cites W2898830231 @default.
- W4384408093 cites W2902185751 @default.
- W4384408093 cites W2902817793 @default.
- W4384408093 cites W2907564726 @default.
- W4384408093 cites W2909312563 @default.
- W4384408093 cites W2914442592 @default.
- W4384408093 cites W2961435469 @default.
- W4384408093 cites W2967217932 @default.
- W4384408093 cites W2983934251 @default.
- W4384408093 cites W2997362338 @default.
- W4384408093 cites W2999263395 @default.
- W4384408093 cites W2999776954 @default.
- W4384408093 cites W3002671583 @default.
- W4384408093 cites W3005411249 @default.