FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384408429> ?p ?o ?g. }

• W4384408429 endingPage "556" @default.
• W4384408429 startingPage "547" @default.
• W4384408429 abstract "Context: Marine ecosystems are sources of bioactive compounds. Thirty-eight microorganism strains from the Cuban platform were screened, which allowed us to identify an extract from Bacillus amyloliquefaciens, strain CBM-116, as a source for obtaining bioproducts with biomedical applications. Aims: To physiologically characterize the culture of Bacillus amyloliquefaciens (CBM-116 strain) and to evaluate the antioxidant and toxic potentialities in vitro of the M116 extract obtained from CBM-116. Methods: The growth and metabolite production of the culture were evaluated at a sieve scale. The chemical composition of the M116 extract obtained from the fermented CBM-116 culture was qualitatively characterized. The extract antioxidant activity was measured by DPPH• and FRAP assays, while cytotoxicity was evaluated in MDCK, J774, CT26, 4T1, MCF-7, A549 cell lines and in Caulobacter crescentus, as well as the effects on genetic material by SOS colorimetric and Rifampicin Resistance, in the last model. Results: Grow kinetic parameters of CBM-116 showed the formation of protein metabolites, while the extract revealed antioxidant capacity, which was evidenced by its iron-reducing capacity. M116 was not cytotoxic up to 2000 μg/mL in C. crescentus; however, it induced mutagenicity and primary damage to the DNA of the bacteria. The extract significantly inhibited cell viability of CT26, 4T1, MCF-7, A549 cells after 48 hours’ exposure. Mean inhibitory concentration (IC50) was calculated for CT26 and 4T1 cells with values of 384 and 488 µg/mL, respectively, in the MTT assay. In the neutral red assay, the values were 478.6 and 398 µg/mL, respectively. Meanwhile, the selectivity index showed values above 2 for both assays. MDCK and J774 cells were not affected. Conclusions: The M116 extract obtained from B. amyloliquefaciens showed bioactive properties with potential application for developing new anti-tumor agents." @default.
• W4384408429 created "2023-07-16" @default.
• W4384408429 creator A5009376258 @default.
• W4384408429 creator A5016620143 @default.
• W4384408429 creator A5021354431 @default.
• W4384408429 creator A5025494101 @default.
• W4384408429 creator A5038290301 @default.
• W4384408429 creator A5038333102 @default.
• W4384408429 creator A5053665064 @default.
• W4384408429 creator A5065642494 @default.
• W4384408429 creator A5068270066 @default.
• W4384408429 creator A5070202382 @default.
• W4384408429 creator A5080220324 @default.
• W4384408429 creator A5087040030 @default.
• W4384408429 creator A5090020485 @default.
• W4384408429 creator A5090864644 @default.
• W4384408429 creator A5092476592 @default.
• W4384408429 date "2023-07-01" @default.
• W4384408429 modified "2023-10-17" @default.
• W4384408429 title "Kinetic characterization, antioxidant and in vitro toxicity potential evaluation of the extract M116 from Bacillus amyloliquefaciens, a Cuban southern coast marine microorganism" @default.
• W4384408429 doi "https://doi.org/10.56499/jppres23.1574_11.4.547" @default.
• W4384408429 hasPublicationYear "2023" @default.
• W4384408429 type Work @default.
• W4384408429 citedByCount "0" @default.
• W4384408429 crossrefType "journal-article" @default.
• W4384408429 hasAuthorship W4384408429A5009376258 @default.
• W4384408429 hasAuthorship W4384408429A5016620143 @default.
• W4384408429 hasAuthorship W4384408429A5021354431 @default.
• W4384408429 hasAuthorship W4384408429A5025494101 @default.
• W4384408429 hasAuthorship W4384408429A5038290301 @default.
• W4384408429 hasAuthorship W4384408429A5038333102 @default.
• W4384408429 hasAuthorship W4384408429A5053665064 @default.
• W4384408429 hasAuthorship W4384408429A5065642494 @default.
• W4384408429 hasAuthorship W4384408429A5068270066 @default.
• W4384408429 hasAuthorship W4384408429A5070202382 @default.
• W4384408429 hasAuthorship W4384408429A5080220324 @default.
• W4384408429 hasAuthorship W4384408429A5087040030 @default.
• W4384408429 hasAuthorship W4384408429A5090020485 @default.
• W4384408429 hasAuthorship W4384408429A5090864644 @default.
• W4384408429 hasAuthorship W4384408429A5092476592 @default.
• W4384408429 hasBestOaLocation W43844084291 @default.
• W4384408429 hasConcept C100544194 @default.
• W4384408429 hasConcept C151730666 @default.
• W4384408429 hasConcept C175605896 @default.
• W4384408429 hasConcept C185592680 @default.
• W4384408429 hasConcept C190283241 @default.
• W4384408429 hasConcept C202751555 @default.
• W4384408429 hasConcept C2777811704 @default.
• W4384408429 hasConcept C2778004101 @default.
• W4384408429 hasConcept C2778767192 @default.
• W4384408429 hasConcept C2779343474 @default.
• W4384408429 hasConcept C2780783641 @default.
• W4384408429 hasConcept C2781401929 @default.
• W4384408429 hasConcept C29537977 @default.
• W4384408429 hasConcept C31903555 @default.
• W4384408429 hasConcept C523546767 @default.
• W4384408429 hasConcept C53227056 @default.
• W4384408429 hasConcept C54355233 @default.
• W4384408429 hasConcept C55493867 @default.
• W4384408429 hasConcept C86803240 @default.
• W4384408429 hasConcept C89423630 @default.
• W4384408429 hasConceptScore W4384408429C100544194 @default.
• W4384408429 hasConceptScore W4384408429C151730666 @default.
• W4384408429 hasConceptScore W4384408429C175605896 @default.
• W4384408429 hasConceptScore W4384408429C185592680 @default.
• W4384408429 hasConceptScore W4384408429C190283241 @default.
• W4384408429 hasConceptScore W4384408429C202751555 @default.
• W4384408429 hasConceptScore W4384408429C2777811704 @default.
• W4384408429 hasConceptScore W4384408429C2778004101 @default.
• W4384408429 hasConceptScore W4384408429C2778767192 @default.
• W4384408429 hasConceptScore W4384408429C2779343474 @default.
• W4384408429 hasConceptScore W4384408429C2780783641 @default.
• W4384408429 hasConceptScore W4384408429C2781401929 @default.
• W4384408429 hasConceptScore W4384408429C29537977 @default.
• W4384408429 hasConceptScore W4384408429C31903555 @default.
• W4384408429 hasConceptScore W4384408429C523546767 @default.
• W4384408429 hasConceptScore W4384408429C53227056 @default.
• W4384408429 hasConceptScore W4384408429C54355233 @default.
• W4384408429 hasConceptScore W4384408429C55493867 @default.
• W4384408429 hasConceptScore W4384408429C86803240 @default.
• W4384408429 hasConceptScore W4384408429C89423630 @default.
• W4384408429 hasIssue "4" @default.
• W4384408429 hasLocation W43844084291 @default.
• W4384408429 hasOpenAccess W4384408429 @default.
• W4384408429 hasPrimaryLocation W43844084291 @default.
• W4384408429 hasRelatedWork W1495820224 @default.
• W4384408429 hasRelatedWork W2093956376 @default.
• W4384408429 hasRelatedWork W2157665874 @default.
• W4384408429 hasRelatedWork W2336258960 @default.
• W4384408429 hasRelatedWork W2341909876 @default.
• W4384408429 hasRelatedWork W2349441214 @default.
• W4384408429 hasRelatedWork W2953214767 @default.
• W4384408429 hasRelatedWork W4229372895 @default.
• W4384408429 hasRelatedWork W4289526470 @default.
• W4384408429 hasRelatedWork W3008390489 @default.
• W4384408429 hasVolume "11" @default.
• W4384408429 isParatext "false" @default.
• W4384408429 isRetracted "false" @default.

• next