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• W4384408461 abstract "Introduction The role of recurrence score in predicting the benefits of adjuvant chemotherapy for lymph-node-positive breast cancer remains uncertain. We studied chemotherapy usage in patients with 1-3 positive lymph nodes and a recurrence score (RS) of 25 or lower to assess changes in clinical practice based on the RxPONDER trial. Methods A retrospective study using the SEER database identified female patients diagnosed with ER-positive, HER2-negative breast cancer, 1-3 positive lymph nodes, and an RS of 25 or lower between 2010 and 2015. Patients were divided into non-chemotherapy and chemotherapy groups, with propensity score weighting to balance clinicopathologic factors. Results Among 7,965 patients, 5,774 (72.5%) were in the non-chemotherapy group, while 2,191 (27.5%) were in the chemotherapy group. Median follow-up was 39 months. Breast cancer accounted for 67 deaths, while 128 deaths were due to other causes. The weighted 5-year overall survival (OS) rates were 95.7% for the non-chemotherapy group and 97.2% for the chemotherapy group. For high-risk patients, the weighted 5-year OS rates were 95.2% and 97.0% for the non-chemotherapy and chemotherapy groups, respectively, with a significant absolute difference of 1.8% (P = 0.014). Multivariate analysis showed a significant difference in weighted hazard ratios for OS between the non-chemotherapy and chemotherapy groups in high-risk patients (hazard ratio: 0.64; 95% CI: 0.48-0.86). However, there were no significant differences in weighted hazard ratios for lower-risk patients, and similar results were observed for breast cancer-specific survival (BCSS). Conclusion Patients with ER-positive, HER2-negative breast cancer and 1-3 positive lymph nodes, assessed by a 21-gene RS of 0-25, exhibited heterogeneous prognosis. Adjuvant chemotherapy provided a significant survival benefit, especially for patients with RS of 14-25, particularly those with invasive ductal carcinoma (IDC) and 2-3 positive lymph nodes." @default.
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• W4384408461 date "2023-07-01" @default.
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• W4384408461 title "Survival Benefit of Adjuvant Chemotherapy in Node-Positive Breast Cancer with a 21-Gene Recurrence Score of 14 to 25: A Real-World Study Based on the Inverse Probability of Treatment Weighting Method" @default.
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• W4384408461 doi "https://doi.org/10.1016/j.clbc.2023.07.004" @default.
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