Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384457718> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W4384457718 abstract "Cell senescence suppresses tumors by arresting cells at risk of becoming malignant. However, this process in turn can affect the microenvironment, leading to acquisition of a senescence-associated secretory phenotype (SASP) that renders senescent cells proinflammatory and results in tumor progression. But how is SASP controlled? In this issue of the JCI, Attig and Pape et al. describe the role of chimeric calbindin 1 (CALB1) transcripts, which are driven by an upstream human endogenous retrovirus subfamily H (HERVH) element. The authors propose that in lung squamous cell carcinoma (LUSC), HERVH-driven isoforms of calbindin (HERVH-CALB1) counteract SASP. As an alternative promoter, HERVH drove calbindin isoforms that prevented cancer cell senescence and associated inflammation, which was associated with better patient survival. We comment on the similarities between HERVH-CALB1–related cellular fitness in cancer and early embryogenesis and discuss the potential benefits of HERVH-driven chimeric transcripts." @default.
- W4384457718 created "2023-07-16" @default.
- W4384457718 creator A5029145656 @default.
- W4384457718 creator A5043517944 @default.
- W4384457718 creator A5091107681 @default.
- W4384457718 creator A5092478827 @default.
- W4384457718 date "2023-07-17" @default.
- W4384457718 modified "2023-10-18" @default.
- W4384457718 title "Staring at the onco-exaptation: the two-faced medley of an ancient retrovirus, HERVH" @default.
- W4384457718 cites W1975643185 @default.
- W4384457718 cites W1982481909 @default.
- W4384457718 cites W1992673078 @default.
- W4384457718 cites W2074637575 @default.
- W4384457718 cites W2185435318 @default.
- W4384457718 cites W231105626 @default.
- W4384457718 cites W2340636398 @default.
- W4384457718 cites W2346199593 @default.
- W4384457718 cites W2360800897 @default.
- W4384457718 cites W2508069933 @default.
- W4384457718 cites W2912064886 @default.
- W4384457718 cites W2921681769 @default.
- W4384457718 cites W2929679098 @default.
- W4384457718 cites W2942910249 @default.
- W4384457718 cites W2959311507 @default.
- W4384457718 cites W3005218670 @default.
- W4384457718 cites W3101858066 @default.
- W4384457718 cites W3162125475 @default.
- W4384457718 cites W3180778035 @default.
- W4384457718 cites W3200783369 @default.
- W4384457718 cites W4225471550 @default.
- W4384457718 cites W4292755991 @default.
- W4384457718 cites W4293778334 @default.
- W4384457718 cites W4376642835 @default.
- W4384457718 cites W4381328814 @default.
- W4384457718 doi "https://doi.org/10.1172/jci172278" @default.
- W4384457718 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37463444" @default.
- W4384457718 hasPublicationYear "2023" @default.
- W4384457718 type Work @default.
- W4384457718 citedByCount "0" @default.
- W4384457718 crossrefType "journal-article" @default.
- W4384457718 hasAuthorship W4384457718A5029145656 @default.
- W4384457718 hasAuthorship W4384457718A5043517944 @default.
- W4384457718 hasAuthorship W4384457718A5091107681 @default.
- W4384457718 hasAuthorship W4384457718A5092478827 @default.
- W4384457718 hasBestOaLocation W43844577181 @default.
- W4384457718 hasConcept C104317684 @default.
- W4384457718 hasConcept C127716648 @default.
- W4384457718 hasConcept C164027704 @default.
- W4384457718 hasConcept C203014093 @default.
- W4384457718 hasConcept C2776914184 @default.
- W4384457718 hasConcept C2778431562 @default.
- W4384457718 hasConcept C502942594 @default.
- W4384457718 hasConcept C522857546 @default.
- W4384457718 hasConcept C54355233 @default.
- W4384457718 hasConcept C81885089 @default.
- W4384457718 hasConcept C86803240 @default.
- W4384457718 hasConcept C95444343 @default.
- W4384457718 hasConceptScore W4384457718C104317684 @default.
- W4384457718 hasConceptScore W4384457718C127716648 @default.
- W4384457718 hasConceptScore W4384457718C164027704 @default.
- W4384457718 hasConceptScore W4384457718C203014093 @default.
- W4384457718 hasConceptScore W4384457718C2776914184 @default.
- W4384457718 hasConceptScore W4384457718C2778431562 @default.
- W4384457718 hasConceptScore W4384457718C502942594 @default.
- W4384457718 hasConceptScore W4384457718C522857546 @default.
- W4384457718 hasConceptScore W4384457718C54355233 @default.
- W4384457718 hasConceptScore W4384457718C81885089 @default.
- W4384457718 hasConceptScore W4384457718C86803240 @default.
- W4384457718 hasConceptScore W4384457718C95444343 @default.
- W4384457718 hasIssue "14" @default.
- W4384457718 hasLocation W43844577181 @default.
- W4384457718 hasLocation W43844577182 @default.
- W4384457718 hasLocation W43844577183 @default.
- W4384457718 hasLocation W43844577184 @default.
- W4384457718 hasOpenAccess W4384457718 @default.
- W4384457718 hasPrimaryLocation W43844577181 @default.
- W4384457718 hasRelatedWork W1966477543 @default.
- W4384457718 hasRelatedWork W2031419065 @default.
- W4384457718 hasRelatedWork W2083887508 @default.
- W4384457718 hasRelatedWork W2108273756 @default.
- W4384457718 hasRelatedWork W2115852450 @default.
- W4384457718 hasRelatedWork W2117470261 @default.
- W4384457718 hasRelatedWork W2141419914 @default.
- W4384457718 hasRelatedWork W2165578318 @default.
- W4384457718 hasRelatedWork W2313033156 @default.
- W4384457718 hasRelatedWork W2890460021 @default.
- W4384457718 hasVolume "133" @default.
- W4384457718 isParatext "false" @default.
- W4384457718 isRetracted "false" @default.
- W4384457718 workType "article" @default.